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2.1.1.115: (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase

This is an abbreviated version!
For detailed information about (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase, go to the full flat file.

Reaction

S-adenosyl-L-methionine
+
(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline
=
S-adenosyl-L-homocysteine
+
N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline

Synonyms

Norreticuline N-methyltransferase, Methyltransferase, tetrahydrobenzylisoquinoline, (R,S)-Tetrahydrobenzylisoquinoline-N-methyltransferase, NMT

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.115 (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase

Systematic Name

Systematic Name on EC 2.1.1.115 - (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase

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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase
Broad substrate specificity for (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinolines; including coclaurine, norcoclaurine, isococlaurine, norarmepavine, norreticuline and tetrahydropapaverine. Both R- and S-enantiomers are methylated. The enzyme participates in the pathway leading to benzylisoquinoline alkaloid synthesis in plants. The physiological substrate is likely to be coclaurine. The enzyme was earlier termed norreticuline N-methyltransferase. However, norreticuline has not been found to occur in nature and that name does not reflect the broad specificity of the enzyme for (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinolines.