2.1.1.115: (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase
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For detailed information about (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase, go to the full flat file.
Reaction
Synonyms
(R,S)-Tetrahydrobenzylisoquinoline-N-methyltransferase, Methyltransferase, tetrahydrobenzylisoquinoline, NMT, Norreticuline N-methyltransferase
ECTree
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Systematic Name
Systematic Name on EC 2.1.1.115 - (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase
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S-adenosyl-L-methionine:(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase
Broad substrate specificity for (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinolines; including coclaurine, norcoclaurine, isococlaurine, norarmepavine, norreticuline and tetrahydropapaverine. Both R- and S-enantiomers are methylated. The enzyme participates in the pathway leading to benzylisoquinoline alkaloid synthesis in plants. The physiological substrate is likely to be coclaurine. The enzyme was earlier termed norreticuline N-methyltransferase. However, norreticuline has not been found to occur in nature and that name does not reflect the broad specificity of the enzyme for (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinolines.