2.1.1.115: (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase

This is an abbreviated version!
For detailed information about (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase, go to the full flat file.

Reaction

S-adenosyl-L-methionine
+
(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline
=
S-adenosyl-L-homocysteine
+
N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline

Synonyms

Norreticuline N-methyltransferase, Methyltransferase, tetrahydrobenzylisoquinoline, (R,S)-Tetrahydrobenzylisoquinoline-N-methyltransferase, NMT

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.115 (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase

Substrates Products

Substrates Products on EC 2.1.1.115 - (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-Adenosyl-L-methionine + (R)-6-O-methylnorlaudanosoline
?
show the reaction diagram
Berberis koetineana
-
-
-
-
?
S-Adenosyl-L-methionine + (R)-norcoclaurine
?
show the reaction diagram
Berberis koetineana
-
-
-
-
?
S-Adenosyl-L-methionine + (R)-norprotosinomenine
?
show the reaction diagram
Berberis koetineana
-
isoenzyme NMT-I: 6% of maximal activity with (R)-tetrahydropapaverine
-
-
?
S-Adenosyl-L-methionine + (R,S)-4'-O-methylnorlaudanosoline
?
show the reaction diagram
Berberis koetineana
-
isoenzyme NMT-I: 3% of maximal activity with (R)-tetrahydropapaverine
-
-
?
S-Adenosyl-L-methionine + (R,S)-7-O-methylnorlaudanosoline
?
show the reaction diagram
Berberis koetineana
-
isoenzyme NMT-I: 12% of maximal activity with (R)-tetrahydropapaverine
-
-
?
S-Adenosyl-L-methionine + (R,S)-isococlaurine
?
show the reaction diagram
Berberis koetineana
-
-
-
-
?
S-Adenosyl-L-methionine + (R,S)-norarmepavine
?
show the reaction diagram
Berberis koetineana
-
-
-
-
?
S-Adenosyl-L-methionine + (R,S)-norcodamine
?
show the reaction diagram
Berberis koetineana
-
-
-
-
?
S-Adenosyl-L-methionine + (R,S)-nororientaline
?
show the reaction diagram
Berberis koetineana
-
-
-
-
?
S-Adenosyl-L-methionine + (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline
?
show the reaction diagram
Berberis koetineana
-
-
-
-
?
S-Adenosyl-L-methionine + (S)-6-O-methylnorlaudanosoline
?
show the reaction diagram
Berberis koetineana
-
-
-
-
?
S-Adenosyl-L-methionine + (S)-norcoclaurine
?
show the reaction diagram
Berberis koetineana
-
-
-
-
?
S-Adenosyl-L-methionine + coclaurine
?
show the reaction diagram
Berberis koetineana
-
-
-
-
?
S-Adenosylmethionine + (R)-coclaurine
S-Adenosyl-L-homocysteine + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline
show the reaction diagram
Berberis koetineana
-
isoenzyme NMT-II and NMT-III show maximal activity with (R)-coclaurine
-
?
S-Adenosylmethionine + (R)-norreticuline
?
show the reaction diagram
Berberis koetineana
-
-
-
-
?
S-Adenosylmethionine + (R)-tetrahydropapaverine
?
show the reaction diagram
Berberis koetineana
-
isoenzyme NMT-I shows maximal activity with (R)-tetrahydropapaverine
-
-
?
S-Adenosylmethionine + (S)-coclaurine
S-Adenosylhomocysteine + N-methylcoclaurine
show the reaction diagram
Berberis koetineana
-
-
-
?
S-Adenosylmethionine + (S)-norreticuline
S-Adenosylhomocysteine + (S)-scoulerine
show the reaction diagram
Berberis koetineana
-
-
-
?
S-Adenosylmethionine + (S)-tetrahydropapaverine
?
show the reaction diagram
Berberis koetineana
-
-
-
-
?