1.97.1.4: [formate-C-acetyltransferase]-activating enzyme

This is an abbreviated version!
For detailed information about [formate-C-acetyltransferase]-activating enzyme, go to the full flat file.

Word Map on EC 1.97.1.4

Reaction

S-adenosyl-L-methionine
+
dihydroflavodoxin
+
[formate C-acetyltransferase]-glycine
=
5'-deoxyadenosine
+
L-methionine
+
flavodoxin semiquinone
+
[formate C-acetyltransferase]-glycin-2-yl radical
+
H+

Synonyms

PFL-glycine:S-adenosyl-L-methionine H transferase (flavodoxin-oxidizing, S-adenosyl-L-methionine-cleaving), Activase, pyruvate formate-lyase, Formate acetyltransferase activase, Pyruvate formate-lyase activase, Pyruvate formate-lyase activating enzyme, PFL-AE, Formate-lyase-activating enzyme, PFL activase, PFL-activating enzyme, PFL, pyruvate formate lyase activating enzyme, PFL activating enzyme, pyruvate formate-lyase-activating enzyme, PflA

ECTree

     1 Oxidoreductases
         1.97 Other oxidoreductases
             1.97.1 Sole sub-subclass for oxidoreductases that do not belong in the other subclasses
                1.97.1.4 [formate-C-acetyltransferase]-activating enzyme

General Information

General Information on EC 1.97.1.4 - [formate-C-acetyltransferase]-activating enzyme

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
malfunction
mutation of either pflB, which codes for PFL, or pflA, which codes for pyruvate formate lyase activating enzyme, results in abrogation of mixed acid fermentation on galactose, and leads to a decrease in pneumococcal virulence
metabolism
evolution
pyruvate formate-lyase activating enzyme (PFL-AE) is a member of the large and diverse radical S-adenosyl-L-methionine (SAM) superfamily, members of which use an iron-sulfur cluster and SAM to initiate difficult radical transformations in all kingdoms of life. Radical SAM enzymes share a common CX3CX2C motif or variation thereof, and the conserved cysteines coordinate three irons of a [4Fe-4S] cluster, while SAM coordinates the fourth iron through its amino and carboxylate moieties