1.8.5.8: eukaryotic sulfide quinone oxidoreductase

This is an abbreviated version!
For detailed information about eukaryotic sulfide quinone oxidoreductase, go to the full flat file.

Reaction

Synonyms

glutathione:CoQ reductase, HMT2, ScSQR, SQOR, SQR, Sqrdl, sulfide : quinone oxidoreductase, sulfide quinone oxidoreductase, sulfide:quinone oxidoreductase

ECTree

     1 Oxidoreductases

         1.8 Acting on a sulfur group of donors

             1.8.5 With a quinone or similar compound as acceptor

                1.8.5.8 eukaryotic sulfide quinone oxidoreductase

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Results	in table
2	Activating Compound
11	AA Sequence
3	Application
6	Cloned(Commentary)
17	Cofactor
3	Crystallization (Commentary)
2	Expression
27	General Information
1	General Stability
5	IC50 Value
22	Inhibitors
15	kcat/KM [mM/s]
4	Ki Value [mM]
22	KM Value [mM]
17	Localization
13	Natural Substrates/ Products (Substrates)
19	Organism
4	Pathway
2	pH Optimum
1	pH Range
1	pI Value
2	Posttranslational Modification
2	Protein Variants
6	Purification (Commentary)
5	Reaction
19	Reference
18	Source Tissue
1	Specific Activity [micromol/min/mg]
44	Substrates and Products (Substrate)
6	Subunits
43	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]
11	Turnover Number [1/s]

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Engineering on EC 1.8.5.8 - eukaryotic sulfide quinone oxidoreductase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

E213K

Homo sapiens

Q9Y6N5

naturally occuring mutation the mutation affects a residue that is remote from the active site, but predicted to disrupt hydrogen bonding with neighboring arginine residues. The mutation leads to greatly diminished SQOR levels in tissues expressing the E213K mutation

764484

additional information

Homo sapiens

Q9Y6N5

a patient is homozygous for a single base pair deletion (c446delT) in the SQOR gene, predicted to lead to mRNA degradation or production of nonfunctional enzyme due to the resulting frameshift, SQOR is not detected in fibroblasts carrying the deletion mutation

764484