1.4.3.14: L-lysine oxidase
This is an abbreviated version!
For detailed information about L-lysine oxidase, go to the full flat file.
Reaction
Synonyms
AIP, apoptosis-inducing protein, L-LOX/MOG, L-lysine alpha-oxidase, L-lysine oxidase/monooxygenase, L-lysine-a-oxidase, L-lysine-alpha-oxidase, L-lysyl-alpha-oxidase, L6150, LyOx, lysine-oxidase, LysOx
ECTree
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Substrates Products
Substrates Products on EC 1.4.3.14 - L-lysine oxidase
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REACTION DIAGRAM
2,6-diaminopimelate + O2 + H2O
?
-
22% activity compared to L-lysine
-
-
?
5-hydroxy-DL-lysine + O2 + H2O
6-amino-5-hydroxy-2-oxohexanoate + NH3 + H2O2
-
5% activity compared to L-lysine
-
-
?
L-tyrosine + O2 + H2O
3-(4-hydroxyphenyl)pyruvate + NH3 + H2O2
-
-
-
?
L-tyrosine + O2 + H2O
4-hydroxyphenylpyruvate + NH3 + H2O2
-
1.4% activity compared to L-lysine
-
-
?
5-carbamidamido-2-oxopentanoate + NH3 + H2O2
-
5.8% activity compared to L-lysine
-
-
?
L-arginine + O2 + H2O
5-carbamidamido-2-oxopentanoate + NH3 + H2O2
Trichoderma cf. aureoviride
-
8.3% activity compared to L-lysine
-
-
?
L-arginine + O2 + H2O
5-carbamidamido-2-oxopentanoate + NH3 + H2O2
Trichoderma cf. aureoviride Rifai VKM F-4268D
-
8.3% activity compared to L-lysine
-
-
?
5-guanidino-2-oxopentanoate + NH3 + H2O2
-
12.8% activity compared to L-lysine
-
-
?
L-arginine + O2 + H2O
5-guanidino-2-oxopentanoate + NH3 + H2O2
-
-
-
?
L-arginine + O2 + H2O
5-guanidino-2-oxopentanoate + NH3 + H2O2
-
-
-
?
L-arginine + O2 + H2O
5-guanidino-2-oxopentanoate + NH3 + H2O2
-
-
-
?
L-arginine + O2 + H2O
5-guanidino-2-oxopentanoate + NH3 + H2O2
-
-
-
?
L-arginine + O2 + H2O
5-guanidino-2-oxopentanoate + NH3 + H2O2
-
6.3% activity compared to L-lysine
-
-
?
L-arginine + O2 + H2O
5-guanidino-2-oxopentanoate + NH3 + H2O2
-
-
-
?
L-arginine + O2 + H2O
5-guanidino-2-oxopentanoate + NH3 + H2O2
-
6.3% activity compared to L-lysine
-
-
?
3-(1H-imidazol-4-yl)-2-oxopropanoate + NH3 + H2O2
-
-
-
?
L-histidine + O2 + H2O
3-(1H-imidazol-4-yl)-2-oxopropanoate + NH3 + H2O2
-
-
-
?
L-histidine + O2 + H2O
3-(1H-imidazol-4-yl)-2-oxopropanoate + NH3 + H2O2
-
only 1% in comparison with L-lysine
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
enzymes with dual activities in a single active site: L-lysine oxidase and L-lysine monooxygenase
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
the mechanistic features are reported that are important for allowing the single active site of L-LOX/MOG to catalyze the two reactions of apparent monooxygenation and the oxidation of the flavoprotein oxidase
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
100% activity
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
100% activity
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
Trichoderma aureoviride Rifai VKM F-4268D
-
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
Trichoderma cf. aureoviride
-
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
Trichoderma cf. aureoviride
-
the stereospecific enzyme oxidizes almost exclusively L-lysine
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
Trichoderma cf. aureoviride Rifai VKM F-4268D
-
the stereospecific enzyme oxidizes almost exclusively L-lysine
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
Trichoderma cf. aureoviride Rifai VKM F-4268D
-
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
most favored substrate
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
preferred substrate
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
preferred substrate
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
also other alpha,omega-diaminomonocarboxylates and L-lysine hydroxamate are oxidized
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
lysine metabolism
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
lysine metabolism
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
100% activity
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
the molecular mechanism of the strict specificity for L-lysine is explained
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
preferred substrate
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
100% activity
-
-
?
5-amino-2-oxopentanoate + NH3 + H2O2
enzymes with dual activities in a single active site: L-lysine oxidase and L-lysine monooxygenase
-
-
?
L-ornithine + O2 + H2O
5-amino-2-oxopentanoate + NH3 + H2O2
Trichoderma cf. aureoviride
-
5.8% activity compared to L-lysine
-
-
?
L-ornithine + O2 + H2O
5-amino-2-oxopentanoate + NH3 + H2O2
Trichoderma cf. aureoviride Rifai VKM F-4268D
-
5.8% activity compared to L-lysine
-
-
?
5-amino-2-oxopentanoic acid + NH3 + H2O2
the mechanistic features are reported that are important for allowing the single active site of L-LOX/MOG to catalyze the two reactions of apparent monooxygenation and the oxidation of the flavoprotein oxidase
-
-
?
L-ornithine + O2 + H2O
5-amino-2-oxopentanoic acid + NH3 + H2O2
-
6% activity compared to L-lysine
-
-
?
L-ornithine + O2 + H2O
5-amino-2-oxopentanoic acid + NH3 + H2O2
-
8.3% activity compared to L-lysine
-
-
?
L-ornithine + O2 + H2O
5-amino-2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
L-ornithine + O2 + H2O
5-amino-2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
L-ornithine + O2 + H2O
5-amino-2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
L-ornithine + O2 + H2O
5-amino-2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
L-ornithine + O2 + H2O
5-amino-2-oxopentanoic acid + NH3 + H2O2
-
18.3% activity compared to L-lysine
-
-
?
L-ornithine + O2 + H2O
5-amino-2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
L-ornithine + O2 + H2O
5-amino-2-oxopentanoic acid + NH3 + H2O2
-
18.3% activity compared to L-lysine
-
-
?
phenylpyruvate + NH3 + H2O2
-
-
-
?
L-phenylalanine + O2 + H2O
phenylpyruvate + NH3 + H2O2
-
16% in comparison to L-lysine
-
?
L-phenylalanine + O2 + H2O
phenylpyruvate + NH3 + H2O2
-
1.7% activity compared to L-lysine
-
-
?
L-phenylalanine + O2 + H2O
phenylpyruvate + NH3 + H2O2
-
16% in comparison to L-lysine
-
?
L-phenylalanine + O2 + H2O
phenylpyruvate + NH3 + H2O2
-
1.7% activity compared to L-lysine
-
-
?
?
-
-
the enzyme shows no activity with L-histidine, L-aspartic acid, glycine, L-phenylalanine, L-alanine, L-arginine, L-glutamic acid, L-isoleucine, L-leucine, L-serine, L-proline, L-threonine, L-glutamine, L-asparagine, L-threonine, L-tryptophan, L-tyrosine, L-valine, L-methionine, L-cysteine and D-lysine
-
-
?
additional information
?
-
-
very low activity with DL-phenylalanine, L-histidine, L-arginine, DL-methionine and L-glycine
-
-
?
additional information
?
-
-
no activity with L-cysteine, L-asparagine-NH2, DL-serine, DL-asparagine and DL-glutamic acid
-
-
?
additional information
?
-
-
no activity with N-2-trifluoroacetyl-L-lysine, 6-aminocaproic acid, 1,4-diaminobutane, L-alanine, L-leucine, L-glutamic acid, L-2,7-diamino heptanoic acid, L-glutamine, and D-lysine
-
-
?
additional information
?
-
Trichoderma cf. aureoviride
-
no activity with The L-isomers of leucine, phenylalanine, citrulline, alanine, asparagine, histidine, ornithine, glutamine, threonine, tyrosine, isoleucine, valine, as well as glycine and D-lysine
-
-
?
additional information
?
-
Trichoderma cf. aureoviride Rifai VKM F-4268D
-
no activity with The L-isomers of leucine, phenylalanine, citrulline, alanine, asparagine, histidine, ornithine, glutamine, threonine, tyrosine, isoleucine, valine, as well as glycine and D-lysine
-
-
?
additional information
?
-
-
very low activity with DL-phenylalanine and DL-methionine
-
-
?
additional information
?
-
-
no activity with L-cysteine, L-asparagine-NH2, DL-serine, DL-asparagine and DL-glutamic acid
-
-
?
additional information
?
-
-
no activity with L-cysteine, L-asparagine-NH2, DL-serine, DL-asparagine and DL-glutamic acid
-
-
?
additional information
?
-
-
very low activity with several other amino acids
-
-
?
additional information
?
-
-
several amino acids, amino acid derivatives and other substances that are assumed to be possible substrates are tested
-
-
?
additional information
?
-
-
no activity with L-cysteine, L-asparagine-NH2, DL-serine, DL-asparagine and DL-glutamic acid
-
-
?
additional information
?
-
-
commercially manufactured LyOx is generally not highly selective for L-Lys among amino acids
-
-
?
additional information
?
-
-
several amino acids, amino acid derivatives and other substances that are assumed to be possible substrates are tested
-
-
?