1.2.1.76: succinate-semialdehyde dehydrogenase (acylating)

This is an abbreviated version!
For detailed information about succinate-semialdehyde dehydrogenase (acylating), go to the full flat file.

Reaction

succinate semialdehyde
+
CoA
+
NADP+
=
succinyl-CoA
+
NADPH
+
H+

Synonyms

Tneu_0421

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.76 succinate-semialdehyde dehydrogenase (acylating)

Systematic Name

Systematic Name on EC 1.2.1.76 - succinate-semialdehyde dehydrogenase (acylating)

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SYSTEMATIC NAME
IUBMB Comments
succinate semialdehyde:NADP+ oxidoreductase (CoA-acylating)
Catalyses the NADPH-dependent reduction of succinyl-CoA to succinate semialdehyde. The enzyme has been described in Clostridium kluyveri, where it participates in succinate fermentation [1], and in Metallosphaera sedula, where it participates in the 3-hydroxypropanonate/4-hydroxybutanoate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [2,3].