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Information on EC 1.2.1.76 - succinate-semialdehyde dehydrogenase (acylating)

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IUBMB Comments
Catalyses the NADPH-dependent reduction of succinyl-CoA to succinate semialdehyde. The enzyme has been described in Clostridium kluyveri, where it participates in succinate fermentation , and in Metallosphaera sedula, where it participates in the 3-hydroxypropanonate/4-hydroxybutanoate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [2,3].
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The expected taxonomic range for this enzyme is: Bacteria, Archaea
Synonyms
Tneu_0421, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
succinate semialdehyde + CoA + NADP+ = succinyl-CoA + NADPH + H+
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