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1.13.11.86: 5-aminosalicylate 1,2-dioxygenase

This is an abbreviated version!
For detailed information about 5-aminosalicylate 1,2-dioxygenase, go to the full flat file.

Reaction

5-Aminosalicylate
+
O2
=
(2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate

Synonyms

5AS 1,2-dioxygenase, mabB

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.86 5-aminosalicylate 1,2-dioxygenase

Substrates Products

Substrates Products on EC 1.13.11.86 - 5-aminosalicylate 1,2-dioxygenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1-hydroxy-2-naphthoate + O2
(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate
show the reaction diagram
oxidized by MabB at a rate less than 1% of that observed for 5-aminosalicylate
-
-
?
5-aminosalicylate + O2
(2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate
show the reaction diagram
gentisate + O2
maleylpyruvate
show the reaction diagram
the two oxygen atoms incorporated into the product are both from the dioxygen molecule. Both 5-aminosalicylate and gentisate can be converted by MabB. The catalytic efficiency of MabB for 5-aminosalicylate is much higher (about 70fold) than that for gentisate
-
-
?
additional information
?
-
no activity is detected in reaction with salicylate
-
-
?