1.13.11.86: 5-aminosalicylate 1,2-dioxygenase
This is an abbreviated version!
For detailed information about 5-aminosalicylate 1,2-dioxygenase, go to the full flat file.
Reaction
Synonyms
5AS 1,2-dioxygenase, mabB
ECTree
Advanced search results
Substrates Products
Substrates Products on EC 1.13.11.86 - 5-aminosalicylate 1,2-dioxygenase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REACTION DIAGRAM
1-hydroxy-2-naphthoate + O2
(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate
oxidized by MabB at a rate less than 1% of that observed for 5-aminosalicylate
-
-
?
gentisate + O2
maleylpyruvate
the two oxygen atoms incorporated into the product are both from the dioxygen molecule. Both 5-aminosalicylate and gentisate can be converted by MabB. The catalytic efficiency of MabB for 5-aminosalicylate is much higher (about 70fold) than that for gentisate
-
-
?
additional information
?
-
no activity is detected in reaction with salicylate
-
-
?
(2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate
the enzyme plays an important physiological role in 3-aminobenzoate degradation in Comamonas sp. strain QT12
-
-
?
5-aminosalicylate + O2
(2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate
the two oxygen atoms incorporated into the product are both from the dioxygen molecule. Both 5-aminosalicylate and gentisate can be converted by MabB. The catalytic efficiency of MabB for 5-aminosalicylate is much higher (about 70fold) than that for gentisate
-
-
?
5-aminosalicylate + O2
(2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate
-
the enzyme participates in the metabolism of 5-aminosalicylate
-
-
?
5-aminosalicylate + O2
(2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate
-
the enzyme exhibits no activity with gentisate
-
-
?