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1.1.5.2: glucose 1-dehydrogenase (PQQ, quinone)

This is an abbreviated version!
For detailed information about glucose 1-dehydrogenase (PQQ, quinone), go to the full flat file.

Word Map on EC 1.1.5.2

Reaction

D-glucose
+
ubiquinone
=
D-glucono-1,5-lactone
 +
ubiquinol

Synonyms

(PQQ)GDH, aldose sugar dehydrogenase, Asd, beta-D-glucose:(acceptor) 1-oxidoreductase, D-glucose:(pyrroloquinoline-quinone) 1-oxidoreductase, dehydrogenase, glucose (pyrroloquinoline-quinone), EC 1.1.99.17, GCD, GDH, GDH-B, GDH1, GdhA, GDHm, GlcDH, glucose dehydrogenase, glucose dehydrogenase (PQQ dependent), glucose dehydrogenase (pyrroloquinoline-quinone), glucose dehydrogenase Amano 5, m-GDH, membrane glucose dehydrogenase, membrane-bound glucose dehydrogenase, membrane-bound PQQ-dependent glucose dehydrogenase, mGDH, PQQ GDH, PQQ glucose dehydrogenase, PQQ-dependent GDH, PQQ-dependent glucose dehydrogenase, PQQ-dependent mGDH, PQQ-dependent soluble glucose dehydrogenase, PQQ-GDH, PQQ-glucose dehydrogenase, PQQ-linked GCD, PQQ-sGDH, PqqC, PQQGDH, PQQGDH-B, pyrroloquinoline quinone dependent glucose dehydrogenase, pyrroloquinoline quinone glucose dehydrogenase, pyrroloquinoline quinone-dependent glucose dehydrogenase, QGDH, quinone-dependent glucose dehydrogenase, quinoprotein aldose sugar dehydrogenase, quinoprotein D-glucose dehydrogenase, quinoprotein glucose dehydrogenase, quinoprotein glucose DH, s-GDH, sGDH, sGDH-PQQ, soluble glucose dehydrogenase, soluble PQQ-dependent glucose dehydrogenase, soluble quinoprotein (PQQ-containing) glucose dehydrogenase, Tt_ASD, water-soluble PQQ glucose dehydrogenase, water-soluble pyrroquinoline quinone glucose dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.5 With a quinone or similar compound as acceptor
                1.1.5.2 glucose 1-dehydrogenase (PQQ, quinone)

Inhibitors

Inhibitors on EC 1.1.5.2 - glucose 1-dehydrogenase (PQQ, quinone)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
aptameric enzyme subunit
-
the aptameric enzyme subunit inhibits PQQGDH in the presence of adenosine
-
Ba2+
competitive to Mg2+, wild-type enzyme
Cu2+
-
complete inhibition at 10 mM
D-gluconic acid
-
non-competitive inhibitor to D-glucose and competitive inhibitor to N-methylphenazonium methyl sulfate
D-glucose
ethanol
-
3.6% residual activity at 80% (v/v)
Fe3+
-
complete inhibition at 10 mM
methylhydrazine
Mg2+
competitive to Ca2+, Sr2+, or Ba2+, mutants D354N, N355D, and D354N/N355D
Mn2+
-
slight inhibitory effect
Myxothiazol
-
less than 10% residual activity at 0.1 mM
N-methylphenazonium methyl sulfate
-
-
p-benzoquinone
-
1.7 mM, complete inhibition
PGa4
-
aptamer PGa4 reduces enzymatic activity to 80% at 25 nM
-
pyrroloquinoline quinone
-
substrate inhibition at high concentrations
Sr2+
competitive to Mg2+, wild-type enzyme
Zn2+
-
slight inhibitory effect
additional information
-