1.1.1.6: glycerol dehydrogenase
This is an abbreviated version!
For detailed information about glycerol dehydrogenase, go to the full flat file.
Reaction
Synonyms
B4100_2156, CglD, dehydrogenase, glycerol, GDH, GDH2, GLD, Gld3, GldA, GLDH
ECTree
Advanced search results
Inhibitors
Inhibitors on EC 1.1.1.6 - glycerol dehydrogenase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
1,3-Propanediol
-
competitive inhibitor versus glycerol in direction of glycerol oxidation, noncompetitive inhibitor versus NAD+, competitive inhibitor versus dihydroxyacetone in direction of glycerol reduction, noncompetitive inhibitor versus NADH
2-amino-2-(hydroxymethyl)-1,3-propanediol
-
strong inhibition, IC50 2 mM
catechol
-
i.e. 1,2-butanediol, inactivation, enzyme regains activity after removal of alcohol
ethanol
-
10% v/v: 25-75% loss of activity, depending on substrate, enzyme regains activity after removal of alcohol
isobutanol
-
5% v/v: 0-50% loss of activity, depending on substrate, enzyme regains activity after removal of alcohol
methanol
-
10% v/v: 25-75% loss of activity, 5% v/v, 50-95% loss of activity, depending on substrate, enzyme regains activity after removal of alcohol
n-amyl alcohol
-
2% v/v: 0-50% loss of activity, depending on substrate, enzyme regains activity after removal of alcohol
n-butanol
-
5% v/v: 0-50% loss of activity, depending on substrate, enzyme regains activity after removal of alcohol
n-Propanol
-
5% v/v: 25-60% loss of activity, depending on substrate, enzyme regains activity after removal of alcohol
o-phthalaldehyde
-
inactivation due to intramolecular thioisoindole formation, glycerol partially protects
Tris HCl
Tris buffer lowers the enzyme activity about 7fold in comparison to CHES buffer
-
strongly inhibitory at 100 mM, but slight activation in lower concentration, 1 mM
dihydroxyacetone
noncompetitive product inhibition; noncompetitive product inhibition with respect to NAD+
NADH
-
competitive inhibitor versus NAD+ in direction of glycerol oxidation, noncompetitive inhibitor versus glycerol
NADH
competitive product inhibition; competitive product inhibition
additional information
enzyme inhibition simulations, overview
-