1.1.1.430: D-xylose reductase (NADH)
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For detailed information about D-xylose reductase (NADH), go to the full flat file.
Reaction
Synonyms
CbXR, CT-XR, dsXR, NAD(P)H-dependent D-xylose reductase, NADH-dependent XR, NADPH-preferring xylose reductase, PsXR, XYL1, XYL1.1, XYL1.2, xylose reductase
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Reaction
Reaction on EC 1.1.1.430 - D-xylose reductase (NADH)
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enzymic mechanism in which a catalytic proton bridge from the protonated side chain of Lys80 to the carbonyl group adjacent to the hydride acceptor carbonyl facilitates the chemical reaction step. His113 contributes to positioning of the 9,10-phenanthrenequinone substrate for catalysis. Tyr51 controls release of the hydroquinone product. The proposed chemistry involves delivery of both hydrogens required for reduction of the alpha-dicarbonyl substrate to the carbonyl group undergoing stereoselective transformation. Hydride transfer from NADH probably precedes the transfer of a proton from Tyr51
xylitol + NAD+ = D-xylose + NADH + H+
chemical mechanism of carbonyl reduction by xylose reductase in which transfer of hydride ion is a partially rate-limiting step and precedes the proton-transfer step
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