1.1.1.430: D-xylose reductase (NADH)

This is an abbreviated version!
For detailed information about D-xylose reductase (NADH), go to the full flat file.

Reaction

Synonyms

CbXR, CT-XR, dsXR, NAD(P)H-dependent D-xylose reductase, NADH-dependent XR, NADPH-preferring xylose reductase, PsXR, XYL1, XYL1.1, XYL1.2, xylose reductase

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.430 D-xylose reductase (NADH)

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Results	in table
5	Activating Compound
4	AA Sequence
6	Application
7	Cloned(Commentary)
24	Cofactor
1	Crystallization (Commentary)
1	General Information
10	Inhibitors
41	kcat/KM [mM/s]
9	Ki Value [mM]
35	KM Value [mM]
8	Metals/Ions
3	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
21	Organism
5	pH Optimum
2	pH Range
1	pI Value
14	Protein Variants
3	Purification (Commentary)
4	Reaction
18	Reference
2	Specific Activity [micromol/min/mg]
43	Substrates and Products (Substrate)
5	Subunits
23	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
1	Temperature Range [°C]
6	Temperature Stability [°C]
34	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.1.1.430 - D-xylose reductase (NADH)

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xylitol:NAD+ oxidoreductase

Xylose reductases catalyse the reduction of xylose to xylitol, the initial reaction in the fungal D-xylose degradation pathway. Most of the enzymes exhibit a strict requirement for NADPH (cf. EC 1.1.1.431, D-xylose reductase (NADPH)). Some D-xylose reductases have dual coenzyme specificity, though they still prefer NADPH to NADH (cf. EC 1.1.1.307, D-xylose reductase [NAD(P)H]). The enzyme from Candida parapsilosis is a rare example of a xylose reductase that significantly prefers NADH, with Km and Vmax values for NADH being 10-fold lower and 10-fold higher, respectively, than for NADPH.