1.1.1.422: pseudoephedrine dehydrogenase

This is an abbreviated version!
For detailed information about pseudoephedrine dehydrogenase, go to the full flat file.

Reaction

Synonyms

PseDH

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.422 pseudoephedrine dehydrogenase

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Results	in table
1	AA Sequence
5	Application
4	Cloned(Commentary)
9	Cofactor
3	Crystallization (Commentary)
1	Expression
5	General Information
2	Inhibitors
3	kcat/KM [mM/s]
2	Ki Value [mM]
25	KM Value [mM]
4	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
5	Organism
5	pH Optimum
3	pH Stability
4	Purification (Commentary)
1	Reaction
3	Reference
1	Source Tissue
23	Specific Activity [micromol/min/mg]
60	Substrates and Products (Substrate)
5	Subunits
4	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
3	Temperature Range [°C]
8	Temperature Stability [°C]
25	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.1.1.422 - pseudoephedrine dehydrogenase

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(+)-(1S,2S)-pseudoephedrine:NAD+ 1-oxoreductase

The enzyme, characterized from the bacterium Arthrobacter sp. TS-15, acts on a broad range of different aryl-alkyl ketones, such as haloketones, ketoamines, diketones, and ketoesters. It accepts various types of aryl groups including phenyl-, pyridyl-, thienyl-, and furyl-rings, but the presence of an aromatic ring is essential for the activity. In addition, the presence of a functional group on the alkyl chain, such as an amine, a halogen, or a ketone, is also crucial. The enzyme exhibits a strict anti-Prelog enantioselectivity. When acting on diketones, it catalyses the reduction of only the keto group closest to the ring, with no further reduction to the diol. cf. EC 1.1.1.423, ephedrine dehydrogenase.