1.1.1.422: pseudoephedrine dehydrogenase
This is an abbreviated version!
For detailed information about pseudoephedrine dehydrogenase, go to the full flat file.
Reaction
Synonyms
PseDH
ECTree
1.1.1.422 pseudoephedrine dehydrogenaseAdvanced search results
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Application on EC 1.1.1.422 - pseudoephedrine dehydrogenase
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APPLICATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
industry
the wide substrate spectrum of these dehydrogenases, combined with their regio- and enantioselectivity, suggests a high potential for the industrial production of valuable chiral compounds
synthesis
additional information
both (R,S)-(-)-ephedrine and (S,S)-(+)-pseudoephedrine are constituents of various over-the-counter (OTC) drugs and are also used as decongestants and stimulants. Arthrobacter sp. TS-15 and its isolated ephedrine-oxidizing enzymes have potential for use in decontamination and synthetic applications
synthesis
the wide substrate spectrum of these dehydrogenases, combined with their regio- and enantioselectivity, suggests a high potential for the industrial production of valuable chiral compounds
synthesis
the enzyme catalyzes the oxidation of an isomers of ephedrine and the regio- and enantioselective reduction of sterically demanding substrate 1-phenyl-1,2-propanedione to give (S)-phenylacetylcarbinol. (S)-phenylacetylcarbinol can serve as a precursor in the synthesis of many pharmaceuticals, such as (+)-(S,S)-pseudoephedrine
synthesis
the wide substrate spectrum of the dehydrogenase, combined with its regio- and enantioselectivity, suggests a high potential for the industrial production of valuable chiral compounds
