Any feedback?
Please rate this page

BRENDA support

show all | hide all No of entries

Information on EC - pseudoephedrine dehydrogenase

for references in articles please use BRENDA:EC1.1.1.422
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
The enzyme, characterized from the bacterium Arthrobacter sp. TS-15, acts on a broad range of different aryl-alkyl ketones, such as haloketones, ketoamines, diketones, and ketoesters. It accepts various types of aryl groups including phenyl-, pyridyl-, thienyl-, and furyl-rings, but the presence of an aromatic ring is essential for the activity. In addition, the presence of a functional group on the alkyl chain, such as an amine, a halogen, or a ketone, is also crucial. The enzyme exhibits a strict anti-Prelog enantioselectivity. When acting on diketones, it catalyses the reduction of only the keto group closest to the ring, with no further reduction to the diol. cf. EC, ephedrine dehydrogenase.
Specify your search results
Select one or more organisms in this record: ?
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
The expected taxonomic range for this enzyme is: unclassified Arthrobacter
Reaction Schemes
pseudoephedrine dehydrogenase, more
(+)-(1S,2S)-pseudoephedrine + NAD+ = (S)-2-methylamino-1-phenylpropan-1-one + NADH + H+
show the reaction diagram