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0.19 - 0.22
3-acetylpyridine adenine dinucleotide
0.038
5'-Amino-5'-deoxyinosine 5'-N-phosphate
-
-
0.013
5'-mercapto-5'-deoxyinosine 5'-S-phosphate
-
-
0.19
acetylpyridine adenine dinucleotide
-
-
0.0082 - 0.03
Inosine 5'-diphosphate
0.0017 - 31
inosine 5'-phosphate
0.21
Inosine 5'-phosphorothioate
-
-
0.59 - 1.03
thiazole-4-carboxamide adenine dinucleotide
additional information
additional information
-
0.19
3-acetylpyridine adenine dinucleotide
presence of 100 mM K+, pH 8.0, 25°C
0.22
3-acetylpyridine adenine dinucleotide
absence of K+, pH 8.0, 25°C
0.0033
IMP
at pH 8.0 and 25°C
0.0063
IMP
-
at pH 8.0 and 25°C
0.01
IMP
-
at pH 8.0 and 25°C
0.012
IMP
at pH 8.0 and 25°C
0.012
IMP
pH 8.0, 40°C, recombinant wild-type enzyme and mutant P166S and K481E
0.013
IMP
pH 8.0, 40°C, recombinant mutant enzyme IMPDHDELTACBS
0.015
IMP
-
wild type enzyme, at pH 8.0 and 25°C
0.015
IMP
-
mutant enzyme A267S, at pH 8.0 and 25°C
0.027
IMP
-
pH 8.0, 25°C, recombinant short enzyme CBS-deletion mutant CjIMPDHDELTAS
0.039
IMP
pH 10.0, 30°C, recombinant enzyme, with MgATP2-
0.039
IMP
pH 8.0, 30°C, recombinant enzyme, with MgATP
0.041
IMP
recombinant MtbIMPDH2DELTACBS mutant enzyme, pH 8.0, 22°C
0.049
IMP
-
pH 8.0, 25°C, recombinant short enzyme CBS-deletion mutant ClpIMPDHDELTAL
0.05
IMP
pH 8.0, 30°C, recombinant enzyme, with MgATP2-
0.052
IMP
pH 10.0, 30°C, recombinant enzyme, without MgATP2-
0.052
IMP
pH 8.0, 30°C, recombinant enzyme, without MgATP
0.053
IMP
-
pH 8.0, 30°C, recombinant enzyme, with MgATP2-
0.055
IMP
-
pH 8.0, 25°C, recombinant wild-type enzyme
0.058
IMP
-
pH 8.0, 30°C, recombinant enzyme, without MgATP2-
0.061
IMP
-
pH 8.0, 25°C, recombinant short enzyme CBS-deletion mutant BaIMPDHDELTAS
0.064
IMP
-
pH 8.0, 25°C, recombinant wild-type enzyme
0.078
IMP
recombinant wild-type enzyme, pH 8.0, 22°C
0.079
IMP
-
mutant enzyme S267A of isoform IMPDHA, at pH 8.0 and 25°C
0.08
IMP
-
pH 8.0, 25°C, recombinant wild-type enzyme
0.083
IMP
at pH 8.0 and 25°C
0.087
IMP
-
pH 8.0, 25°C, recombinant short enzyme CBS-deletion mutant VcIMPDHDELTAL
0.0902
IMP
recombinant wild-type enzyme, pH 8.0, 28°C
0.093
IMP
-
wild type enzyme isoform IMPDHA, at pH 8.0 and 25°C
0.1
IMP
-
pH 8.0, 25°C, recombinant wild-type enzyme
0.118
IMP
recombinant AgIMPDH-DELTABateman mutant enzyme, pH 8.0, 28°C
0.12
IMP
Q81W29
pH 8.0, 30°C, recombinant enzyme, without MgATP2-
0.148
IMP
Q81W29
pH 8.0, 30°C, recombinant enzyme, with MgATP2-
0.15
IMP
-
pH 8.0, 25°C, recombinant long enzyme CBS-deletion mutant BaIMPDHDELTAL
0.196
IMP
pH 8.0, 30°C, recombinant enzyme, without MgATP2-
0.197
IMP
pH 8.0, 30°C, recombinant enzyme, with MgATP2-
0.315
IMP
pH 8.0, 30°C, recombinant enzyme, without MgATP2-
0.0082
Inosine 5'-diphosphate
pH 8.0, 25°C
0.018
Inosine 5'-diphosphate
Q81W29
pH 8.0, 22°C
0.03
Inosine 5'-diphosphate
pH 8.0, 25°C
0.0017
inosine 5'-phosphate
-
pH 8.0, 25°C, recombinant full-length enzyme, in presence of 100 mM KCl
0.0017
inosine 5'-phosphate
-
in the presence of 12 mM K+
0.0024
inosine 5'-phosphate
-
pH 8.0, 25°C, recombinant alphabeta core domain, in absence of 100 mM KCl
0.0026
inosine 5'-phosphate
-
pH 8.0, 25°C, recombinant full-length enzyme, in absence of 100 mM KCl
0.003
inosine 5'-phosphate
-
pH 8.0, 25°C, recombinant alphabeta core domain, in presence of 100 mM KCl
0.004
inosine 5'-phosphate
-
isoform IMPDH1(514), pH 8.0, 25°C
0.00455
inosine 5'-phosphate
-
-
0.007
inosine 5'-phosphate
pH 8.0, 37°C, recombinant mutant R224P
0.0091
inosine 5'-phosphate
-
pH 8.8, 30°C
0.0092
inosine 5'-phosphate
-
type 2 isozyme, in the presence of 0.39 mM K+
0.01
inosine 5'-phosphate
-
mutant D226N of isoform IMPDH1(595), pH 8.0, 25°C
0.011
inosine 5'-phosphate
pH 8.0, 37°C, recombinant mutant V268I
0.011
inosine 5'-phosphate
-
isoform IMPDH1(595), pH 8.0, 25°C
0.011
inosine 5'-phosphate
-
mutant D226N of isoform IMPDH1(546), pH 8.0, 25°C
0.012
inosine 5'-phosphate
pH 8.0, 37°C, recombinant mutant D226N
0.0132
inosine 5'-phosphate
-
-
0.014
inosine 5'-phosphate
-
type 1 isozyme, in the presence of 0.65 mM K+
0.015
inosine 5'-phosphate
-
isoform IMPDH1(546), pH 8.0, 25°C
0.017
inosine 5'-phosphate
pH 8.0, 37°C, recombinant wild-type enzyme
0.02
inosine 5'-phosphate
-
pH 7.5, 22°C
0.021
inosine 5'-phosphate
-
6-thioinosine 5'-phosphate, constant in pH-range 6.5-8.2, sharp decrease at higher pH
0.029
inosine 5'-phosphate
-
-
0.029
inosine 5'-phosphate
-
in the presence of 25 mM K+
0.033
inosine 5'-phosphate
-
pH 7.5, 25°C
0.042
inosine 5'-phosphate
-
mutant L263F, 37°C, pH 8.0
0.0458
inosine 5'-phosphate
-
wild-type, 37°C, pH 8.0
0.0509
inosine 5'-phosphate
pH not specified in the publication, temperature not specified in the publication
0.06
inosine 5'-phosphate
-
in the presence of 2.8 mM K+
0.062
inosine 5'-phosphate
-
-
0.078
inosine 5'-phosphate
-
pH 8.0, 25°C
1.7
inosine 5'-phosphate
-
wild-type, pH 8.0, 25°C
7.6
inosine 5'-phosphate
-
mutant R322A, pH 8.0, 25°C
28
inosine 5'-phosphate
-
mutant Q324A, pH 8.0, 25°C
31
inosine 5'-phosphate
-
mutant E323A, pH 8.0, 25°C
2
K+
-
-
0.00157
NAD+
-
-
0.006
NAD+
-
pH 8.0, 25°C
0.007
NAD+
at pH 8.0 and 25°C
0.014
NAD+
-
isoform IMPDH1(514), pH 8.0, 25°C
0.016
NAD+
-
mutant D226N of isoform IMPDH1(595), pH 8.0, 25°C
0.0163
NAD+
-
wild-type, 37°C, pH 8.0
0.018 - 0.035
NAD+
-
pH 8.8, 30°C
0.022
NAD+
-
isoform IMPDH1(546), pH 8.0, 25°C
0.0227
NAD+
-
mutant L263F, 37°C, pH 8.0
0.024
NAD+
-
mutant D226N of isoform IMPDH1(546), pH 8.0, 25°C
0.026
NAD+
-
isoform IMPDH1(595), pH 8.0, 25°C
0.032
NAD+
-
type 2 isozyme, in the presence of 0.39 mM K+
0.042
NAD+
-
type 1 isozyme, in the presence of 0.65 mM K+
0.045
NAD+
-
at pH 8.0 and 25°C
0.046
NAD+
pH 8.0, 37°C, recombinant mutant V268I
0.05
NAD+
pH 8.0, 37°C, recombinant mutant D226N
0.056
NAD+
pH 8.0, 37°C, recombinant mutant R224P
0.066
NAD+
at pH 8.0 and 25°C
0.07
NAD+
pH 8.0, 37°C, recombinant wild-type enzyme
0.08
NAD+
-
at pH 8.0 and 25°C
0.11
NAD+
-
pH 8.0, 25°C, recombinant alphabeta core domain, in presence of 100 mM KCl
0.12
NAD+
-
mutant Q324A, pH 8.0, 25°C
0.12
NAD+
-
wild type enzyme, at pH 8.0 and 25°C
0.14
NAD+
presence of 1 mM K+, pH 8.0, 25°C
0.144
NAD+
pH 8.0, 37°C, recombinant enzyme
0.15
NAD+
-
wild-type, pH 8.0, 25°C
0.15
NAD+
-
pH 8.0, 25°C, recombinant full-length enzyme, in presence of 100 mM KCl
0.15
NAD+
-
in the presence of 12 mM K+
0.19
NAD+
-
mutant enzyme A267S, at pH 8.0 and 25°C
0.22
NAD+
-
pH 8.0, 25°C, recombinant wild-type enzyme
0.269
NAD+
pH 8.0, 30°C, recombinant enzyme, without MgATP2-
0.28
NAD+
recombinant wild-type enzyme, pH 8.0, 28°C
0.3
NAD+
-
mutant E323A, pH 8.0, 25°C
0.33
NAD+
-
mutant enzyme S267A of isoform IMPDHA, at pH 8.0 and 25°C
0.355
NAD+
pH 8.0, 30°C, recombinant enzyme, without MgATP
0.37
NAD+
-
pH 8.0, 25°C, recombinant wild-type enzyme
0.387
NAD+
recombinant AgIMPDH-DELTABateman mutant enzyme, pH 8.0, 28°C
0.39
NAD+
-
pH 7.5, 25°C
0.4
NAD+
-
wild type enzyme isoform IMPDHA, at pH 8.0 and 25°C
0.418
NAD+
pH 8.0, 30°C, recombinant enzyme, with MgATP
0.46
NAD+
-
pH 8.0, 25°C, recombinant long enzyme CBS-deletion mutant BaIMPDHDELTAL
0.477
NAD+
pH 8.0, 30°C, recombinant enzyme, with MgATP2-
0.51
NAD+
-
pH 8.0, 25°C, recombinant short enzyme CBS-deletion mutant ClpIMPDHDELTAL
0.52
NAD+
-
pH 8.0, 25°C, recombinant short enzyme CBS-deletion mutant CjIMPDHDELTAS
0.55
NAD+
Q81W29
pH 8.0, 22°C
0.55
NAD+
-
pH 8.0, 25°C, recombinant wild-type enzyme
0.56
NAD+
-
pH 8.0, 25°C, recombinant short enzyme CBS-deletion mutant BaIMPDHDELTAS
0.58
NAD+
recombinant MtbIMPDH2DELTACBS mutant enzyme, pH 8.0, 22°C
0.7
NAD+
at pH 8.0 and 25°C
0.887
NAD+
recombinant enzyme, pH 8.5, 37°C
0.91
NAD+
-
mutant R322A, pH 8.0, 25°C
0.998
NAD+
pH 10.0, 30°C, recombinant enzyme, without MgATP2-
1.005
NAD+
-
pH 8.0, 25°C
1.005
NAD+
recombinant wild-type enzyme, pH 8.0, 22°C
1.1
NAD+
-
pH 8.0, 25°C, recombinant full-length enzyme, in absence of 100 mM KCl
1.1
NAD+
-
in the presence of 25 mM K+
1.1
NAD+
-
pH 8.0, 25°C, recombinant short enzyme CBS-deletion mutant VcIMPDHDELTAL
1.122
NAD+
-
pH 8.0, 30°C, recombinant enzyme, with MgATP2-
1.175
NAD+
-
pH 8.0, 30°C, recombinant enzyme, without MgATP2-
1.2
NAD+
-
pH 8.0, 25°C, recombinant wild-type enzyme
1.2
NAD+
-
pH 8.0, 25°C, recombinant alphabeta core domain, in absence of 100 mM KCl
1.4
NAD+
absence of K+, pH 8.0, 25°C
1.762
NAD+
pH 10.0, 30°C, recombinant enzyme, with MgATP2-
1.762
NAD+
pH 8.0, 30°C, recombinant enzyme, with MgATP2-
1.994
NAD+
Q81W29
pH 8.0, 30°C, recombinant enzyme, with MgATP2-
2
NAD+
-
in the presence of 2.8 mM K+
2.209
NAD+
Q81W29
pH 8.0, 30°C, recombinant enzyme, without MgATP2-
2.35
NAD+
pH 8.0, 30°C, recombinant enzyme, without MgATP2-
2.4
NAD+
presence of 1 mM K+, pH 8.0, 25°C
2.6
NAD+
-
mutant R322E, pH 8.0, 25°C
2.7
NAD+
pH 8.0, 40°C, recombinant mutant K481E
3.1
NAD+
pH 8.0, 40°C, recombinant wild-type enzyme and mutant IMPDHDELTACBS
3.2
NAD+
pH 8.0, 40°C, recombinant mutant P166S
0.59
thiazole-4-carboxamide adenine dinucleotide
-
chemically synthesized thiazole-4-carboxamide adenine dinucleotide
0.59
thiazole-4-carboxamide adenine dinucleotide
-
with thiazole-4-carboxamide adenine dinucleotide synthesized chemically
0.65
thiazole-4-carboxamide adenine dinucleotide
-
enzymatically synthesized thiazole-4-carboxamide adenine dinucleotide
0.65
thiazole-4-carboxamide adenine dinucleotide
-
with thiazole-4-carboxamide adenine dinucleotide synthesized enzymatically
1.03
thiazole-4-carboxamide adenine dinucleotide
-
ex vivo thiazole-4-carboxamide adenine dinucleotide
1.03
thiazole-4-carboxamide adenine dinucleotide
-
with thiazole-4-carboxamide adenine dinucleotide isolated ex vivo
additional information
additional information
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additional information
additional information
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additional information
additional information
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additional information
additional information
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additional information
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additional information
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additional information
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additional information
additional information
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additional information
additional information
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additional information
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additional information
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additional information
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additional information
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additional information
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kinetics
-
additional information
additional information
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overview
-
additional information
additional information
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overview
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additional information
additional information
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overview
-
additional information
additional information
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overview
-
additional information
additional information
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overview
-
additional information
additional information
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overview
-
additional information
additional information
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wild type and mutants of type II
-
additional information
additional information
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Km over the range of pH 7.3-8.5
-
additional information
additional information
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Michaelis-Menten kinetics
-
additional information
additional information
Michaelis-Menten kinetics
-
additional information
additional information
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Michaelis-Menten kinetics
-
additional information
additional information
Q81W29
Michaelis-Menten kinetics
-
additional information
additional information
Michaelis-Menten kinetics
-
additional information
additional information
Michaelis-Menten kinetics
-
additional information
additional information
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detailed kinetics, pre-steady-state kinetics, mechanistic rate constants, wild-type enzyme and mutant enzymes, overview
-
additional information
additional information
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kinetics, wild-type enzyme and mutant enzymes
-
additional information
additional information
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nucleic acid binding kinetics
-
additional information
additional information
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nucleic acid binding kinetics, recombinant full-length type I isozyme and subdomain
-
additional information
additional information
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nucleic acid binding kinetics, recombinant wild-type and mutant enzyme core domains
-
additional information
additional information
ssDNA binding kinetics of wild-type and mutant IMPDH1s
-
additional information
additional information
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analysis of microscopic rate constants
-
additional information
additional information
Michaelis-Menten enzyme kinetics
-
additional information
additional information
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Michaelis-Menten enzyme kinetics
-
additional information
additional information
enzyme IMPDHnm exhibits cooperative kinetics for IMP with MgATP2- as the positive effector
-
additional information
additional information
enzyme IMPDHpp exhibits cooperative kinetics for IMP with MgATP2- as the positive effector
-
additional information
additional information
steady-state kinetics and kinetic analysis, detailed overview
-