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3-(4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
L-tyrosine + 2-oxoglutarate
-
-
-
?
3-(imidazol-4-yl)-2-oxopropyl phosphate + L-2-aminoadipate
L-histidinol phosphate + 2-oxoadipate
-
40% of the activity with L-glutamate
-
-
r
3-(imidazol-4-yl)-2-oxopropyl phosphate + L-arginine
L-histidinol phosphate + 2-oxo-5-guanidinopentanoate
-
33% of the activity with L-glutamate
-
-
r
3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate
L-histidinol phosphate + 2-oxoglutarate
3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamine
L-histidinol phosphate + 4-carbamoyl-2-oxobutanoate
-
4% of the activity with L-glutamate
-
-
r
3-(imidazol-4-yl)-2-oxopropyl phosphate + L-histidine
L-histidinol phosphate + 3-(1H-imidazol-4-yl)-2-oxopropanoate
-
30% of the activity with L-glutamate
-
-
r
3-indole-2-oxopropanoate + L-glutamate
L-tryptophan + 2-oxoglutarate
-
-
-
?
4-methyl-2-oxopentanoate + L-alanine
L-leucine + pyruvate
-
-
-
?
4-methyl-2-oxopentanoate + L-asparagine
L-leucine + 2-oxosuccinamic acid
-
-
-
?
4-methyl-2-oxopentanoate + L-glutamate
L-leucine + 2-oxoglutarate
-
-
-
?
beta-chloro-L-alanine
pyruvate + NH3 + Cl-
-
-
-
?
L-glutarate + 2-oxobutanoate
2-oxoglutarate + 2-aminobutanoate
-
-
-
?
L-histidine + 2-oxoglutarate
3-(imidazol-4-yl)-2-oxopropanoate + L-glutamate
-
-
-
-
?
L-histidinol phosphate + 2-oxo-5-guanidinopentanoate
3-(imidazol-4-yl)-2-oxopropyl phosphate + L-arginine
-
-
-
-
r
L-histidinol phosphate + 2-oxoadipate
3-(imidazol-4-yl)-2-oxopropyl phosphate + 2-aminoadipate
-
70% of the activity with 2-oxoglutarate
-
-
r
L-histidinol phosphate + 2-oxoglutarate
3-(imidazol-4-yl)-2-oxopropyl phosphate + L-Glu
L-histidinol phosphate + 2-oxoglutarate
3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate
L-histidinol phosphate + 4-hydroxyphenylpyruvate
3-(imidazol-4-yl)-2-oxopropyl phosphate + L-tyrosine
-
-
-
-
?
L-histidinol phosphate + oxaloacetate
3-(imidazol-4-yl)-2-oxopropyl phosphate + L-aspartate
-
-
-
-
?
L-histidinol phosphate + phenylpyruvate
3-(imidazol-4-yl)-2-oxopropyl phosphate + L-phenylalanine
-
-
-
-
?
L-histidinol phosphate + pyruvate
3-(imidazol-4-yl)-2-oxopropyl phosphate + L-Ala
-
-
-
-
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
L-tyrosine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropanoate + glutamate
L-tyrosine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
phenylpyruvate + L-glutamate
L-phenylalanine + 2-oxoglutarate
-
-
-
?
additional information
?
-
3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate
L-histidinol phosphate + 2-oxoglutarate
histidine pathway
-
-
?
3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate
L-histidinol phosphate + 2-oxoglutarate
-
eighth step in histidine biosynthesis
-
-
?
L-histidinol phosphate + 2-oxoglutarate
3-(imidazol-4-yl)-2-oxopropyl phosphate + L-Glu
-
-
-
-
?
L-histidinol phosphate + 2-oxoglutarate
3-(imidazol-4-yl)-2-oxopropyl phosphate + L-Glu
-
-
-
?
L-histidinol phosphate + 2-oxoglutarate
3-(imidazol-4-yl)-2-oxopropyl phosphate + L-Glu
-
i.e. imidazoleacetol phosphate + L-Glu
?
L-histidinol phosphate + 2-oxoglutarate
3-(imidazol-4-yl)-2-oxopropyl phosphate + L-Glu
-
-
-
?
L-histidinol phosphate + 2-oxoglutarate
3-(imidazol-4-yl)-2-oxopropyl phosphate + L-Glu
-
-
-
?
L-histidinol phosphate + 2-oxoglutarate
3-(imidazol-4-yl)-2-oxopropyl phosphate + L-Glu
-
-
i.e. imidazoleacetol phosphate + L-Glu
r
L-histidinol phosphate + 2-oxoglutarate
3-(imidazol-4-yl)-2-oxopropyl phosphate + L-Glu
-
-
-
-
?
L-histidinol phosphate + 2-oxoglutarate
3-(imidazol-4-yl)-2-oxopropyl phosphate + L-Glu
-
-
-
-
?
L-histidinol phosphate + 2-oxoglutarate
3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate
-
-
-
?
L-histidinol phosphate + 2-oxoglutarate
3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate
-
-
-
?
L-histidinol phosphate + 2-oxoglutarate
3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate
-
-
-
?
L-histidinol phosphate + 2-oxoglutarate
3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate
-
-
-
r
L-histidinol phosphate + 2-oxoglutarate
3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate
catalytic reaction pathway, histidine biosynthesis
-
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
low activity with
-
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
r
L-tyrosine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropanoate + glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropanoate + glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropanoate + glutamate
-
-
-
-
?
L-tyrosine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
-
-
-
-
?
L-tyrosine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
-
-
-
r
additional information
?
-
-
complete knockout of AtHPA1 is lethal for embryo
-
-
?
additional information
?
-
no substrate: 3-methyl-2-oxopentanoate, 3-methyl-2-oxobutanoate
-
-
?
additional information
?
-
-
no substrate: 3-methyl-2-oxopentanoate, 3-methyl-2-oxobutanoate
-
-
?
additional information
?
-
-
no substrate: oxaloacetate, pyruvate
-
-
?
additional information
?
-
enzyme might also catalyze the transamination reaction with other substrates generating aromatic amino acids in vivo
-
-
?
additional information
?
-
-
enzyme might also catalyze the transamination reaction with other substrates generating aromatic amino acids in vivo
-
-
?
additional information
?
-
no activity with L-histidine
-
-
?
additional information
?
-
-
no activity with L-histidine
-
-
?
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Weigent, D.A.; Nester, E.W.
Purification and properties of two aromatic aminotransferases in Bacillus subtilis
J. Biol. Chem.
251
6974-6980
1976
Bacillus subtilis
brenda
Ames, B.N.; Horecker, B.L.
Biosynthesis of histidine: imidazoleacetol phosphate transaminase
J. Biol. Chem.
220
113-128
1956
Neurospora sp.
brenda
Martin, R.G.; Goldberger, R.F.
Imidazolylacetolphosphate:L-glutamate aminotransferase. Purification and physical properties
J. Biol. Chem.
242
1168-1174
1967
Salmonella enterica subsp. enterica serovar Typhimurium
brenda
Hsu, L.C.; Okamoto, M.; Snell, E.E.
L-Histidinol phosphate aminotransferase from Salmonella typhimurium. Kinetic behavior and sequence at the pyridoxal-P binding site
Biochimie
71
477-489
1989
Salmonella enterica subsp. enterica serovar Typhimurium
brenda
Martin, R.G.; Voll, M.J.; Appella, E.
Imidazolylacetolphosphate:L-glutamate aminotransferase. Composition and substructure
J. Biol. Chem.
242
1175-1181
1967
Salmonella enterica subsp. enterica serovar Typhimurium
brenda
Henderson, G.B.; Snell, E.E.
Crystalline L-histidinol phosphate aminotransferase from Salmonella typhimurium. Purification and subunit structure
J. Biol. Chem.
248
1906-1911
1973
Salmonella enterica subsp. enterica serovar Typhimurium
brenda
Henderson, G.B.; Shaltiel, S.; Snell, E.E.
Omega-aminoalkylagaroses in the purification of L-histidinol-phosphate aminotransferase
Biochemistry
13
4335-4338
1974
Salmonella enterica subsp. enterica serovar Typhimurium
brenda
Roberts, J.H.; Levin, A.P.
Imidazolylacetolphosphate aminotransferase. Properties of the apoprotein produced in a pyridoxine auxotroph of Salmonella typhimurium
J. Biol. Chem.
248
77408-7753
1973
Salmonella enterica subsp. enterica serovar Typhimurium
-
brenda
El Malki, F.; Jacobs, M.
Molecular characterization and expression study of a histidine auxotrophic mutant (his1-) of Nicotiana plumbaginifolia
Plant Mol. Biol.
45
191-199
2001
Nicotiana tabacum (O82030)
brenda
Gu, W.; Zhao, G.; Eddy, C.; Jensen, R.A.
Imidazole acetol phosphate aminotransferase in Zymomonas mobilis: molecular genetic, biochemical, and evolutionary analyses
J. Bacteriol.
177
1576-1584
1995
Zymomonas mobilis
brenda
Haruyama, K.; Nakai, T.; Miyahara, I.; Hirotsu, K.; Mizuguchi, H.; Hayashi, H.; Kagamiyama, H.
Structures of Escherichia coli histidinol-phosphate aminotransferase and its complexes with histidinol-phosphate and N-(5'-phosphopyridoxyl)-L-glutamate: double substrate recognition of the enzyme
Biochemistry
40
4633-4644
2001
Escherichia coli (P06986), Escherichia coli
brenda
Mizuguchi, H.; Hayashi, H.; Miyahara, I.; Hirotsu, K.; Kagamiyama, H.
Characterization of histidinol phosphate aminotransferase from Escherichia coli
Biochim. Biophys. Acta
1647
321-324
2003
Escherichia coli
brenda
Sivaraman, J.; Li, Y.; Larocque, R.; Schrag, J.D.; Cygler, M.; Matte, A.
Crystal structure of histidinol phosphate aminotransferase (HisC) from Escherichia coli, and its covalent complex with pyridoxal-5'-phosphate and l-histidinol phosphate
J. Mol. Biol.
311
761-776
2001
Escherichia coli (P06986), Escherichia coli
brenda
Fernandez, F.J.; Vega, M.C.; Lehmann, F.; Sandmeier, E.; Gehring, H.; Christen, P.; Wilmanns, M.
Structural studies of the catalytic reaction pathway of a hyperthermophilic histidinol-phosphate aminotransferase
J. Biol. Chem.
279
21478-21488
2004
Thermotoga maritima (Q9X0D0), Thermotoga maritima
brenda
Mo, X.; Zhu, Q.; Li, X.; Li, J.; Zeng, Q.; Rong, H.; Zhang, H.; Wu, P.
The hpa1 mutant of Arabidopsis reveals a crucial role of histidine homeostasis in root meristem maintenance
Plant Physiol.
141
1425-1435
2006
Arabidopsis thaliana
brenda
Marienhagen, J.; Sandalova, T.; Sahm, H.; Eggeling, L.; Schneider, G.
Insights into the structural basis of substrate recognition by histidinol-phosphate aminotransferase from Corynebacterium glutamicum
Acta Crystallogr. Sect. D
64
675-685
2008
Corynebacterium glutamicum (Q9KJU4), Corynebacterium glutamicum
brenda
Nasir, N.; Vyas, R.; Chugh, C.; Ahangar, M.S.; Biswal, B.K.
Molecular cloning, overexpression, purification, crystallization and preliminary X-ray diffraction studies of histidinol phosphate aminotransferase (HisC2) from Mycobacterium tuberculosis
Acta Crystallogr. Sect. F
68
32-36
2012
Mycobacterium tuberculosis
brenda
Nasir, N.; Vyas, R.; Biswal, B.K.
Sample preparation, crystallization and structure solution of HisC from Mycobacterium tuberculosis
Acta Crystallogr. Sect. F
69
445-448
2013
Mycobacterium tuberculosis (P9WML7), Mycobacterium tuberculosis H37Rv (P9WML7)
brenda
Nasir, N.; Anant, A.; Vyas, R.; Biswal, B.K.
Crystal structures of Mycobacterium tuberculosis HspAT and ArAT reveal structural basis of their distinct substrate specificities
Sci. Rep.
6
18880
2016
Mycobacterium tuberculosis (P9WML7), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WML7)
brenda
Park, Y.J.; Kenney, G.E.; Schachner, L.F.; Kelleher, N.L.; Rosenzweig, A.C.
Repurposed HisC aminotransferases complete the biosynthesis of some methanobactins
Biochemistry
57
3515-3523
2018
Mycobacterium tuberculosis (P9WML7), Mycobacterium tuberculosis H37Rv (P9WML7)
brenda