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4-hexadecenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxo-6-octadecenoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
acetyl-CoA + malonyl-CoA
3-oxobutyryl-CoA + CoA
-
-
formation of about 1% triacetic acid lactone
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CO2 + CoA
acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
acyl-CoA + [acyl-carrier protein]
acyl-[acyl-carrier protein] + CoA
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]
a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
an acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
a 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
butanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxohexanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
butyryl-CoA + malonyl-[acyl-carrier protein]
?
-
-
-
?
butyryl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
beta-ketohexanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
C10-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
C12-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
C12-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
C14-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
C14-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
C16-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
C4-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
C6-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
C6-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
C8-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
best substrate
-
-
?
C8-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
C10-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
cis-3-decenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxo-cis-5-dodecenoyl-[acyl-carrier protein] + acyl-carrier protein
cis-9-hexadecenoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-hexadecenoyl-[acyl-carrier protein] + CO2 + CoA
-
-
-
-
?
cis-9-hexadecenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxo-cis-11-octadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
cis-mono-unsaturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
cis-mono-unsaturated 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
decanoyl-ACP + malonyl-ACP
?
-
-
-
?
decanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
dodecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
dodecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxotetradecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
eicosanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxodocosanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
hexadecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
hexanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
isobutyryl-CoA + malonyl-[acyl-carrier protein]
?
malonyl-ACP + lauroyl-ACP
?
-
-
-
-
?
malonyl-ACP + lauroyl-CoA
?
-
-
-
-
?
malonyl-ACP + palmitoyl-ACP
?
-
-
-
-
?
malonyl-ACP + palmitoyl-CoA
?
-
-
-
-
?
Malonyl-CoA
Acetyl-CoA + CO2
-
decarboxylation reaction
-
-
?
malonyl-CoA + decanoyl-[acyl carrier protein]
?
-
-
-
-
?
malonyl-CoA + lauroyl-ACP
?
-
-
-
-
?
malonyl-CoA + palmitoyl-ACP
?
-
-
-
-
?
malonyl-CoA + palmitoyl-[acyl-carrier protein]
?
-
-
-
-
?
malonyl-phosphopantetheine-14-mer + lauroyl-ACP
?
-
-
-
-
?
malonyl-phosphopantetheine-14-mer + palmitoyl-ACP
?
-
-
-
-
?
malonyl-phosphopantetheine-16-mer + lauroyl-ACP
?
-
-
-
-
?
malonyl-phosphopantetheine-16-mer + palmitoyl-ACP
?
-
-
-
-
?
malonyl-phosphopantetheine-8-mer + lauroyl-ACP
?
-
-
-
-
?
malonyl-phosphopantetheine-8-mer + palmitoyl-ACP
?
-
-
-
-
?
malonyl-[acyl-carrier protein]
acetyl-[acyl-carrier protein] + CO2
malonyl-[acyl-carrier protein] + lauroyl-CoA
? + CO2 + [acyl-carrier protein]
-
-
-
-
?
malonyl-[acyl-carrier protein] + myristoyl-CoA
? + CO2 + [acyl-carrier protein]
-
-
-
-
?
malonyl-[acyl-carrier protein] + palmitoyl-CoA
? + CO2 + [acyl-carrier protein]
-
-
-
-
?
myristoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxohexadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
octadecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoeicosanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
octanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxodecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
palmitoyl-[acyl-carrier protein] + malonyl-CoA
3-oxostearoyl-[acyl-carrier protein] + CO2 + CoA
-
-
-
-
?
palmitoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
propionyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
beta-ketopentanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
stearoyl-[acyl-carrier protein] + malonyl-CoA
3-oxoeicosanoyl-[acyl-carrier protein] + CO2 + CoA
-
only in sheath epidermis
-
-
?
tetradecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxohexadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
additional information
?
-
4-hexadecenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxo-6-octadecenoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
best substrate, highly specific for
-
-
?
4-hexadecenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxo-6-octadecenoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
reaction is part of petroselinic acid biosynthesis, synthase IV
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
?
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
?
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CO2 + CoA
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CO2 + CoA
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CO2 + CoA
synthase III, best substrate
-
?
acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
ir
acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
r
acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
r
acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
r
acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
synthase III, recombinant enzyme from E. coli is absolutely specific for
-
r
acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
synthase I
-
-
?
acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
synthase III
-
ir
acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
synthase III
-
-
?
acyl-CoA + [acyl-carrier protein]
acyl-[acyl-carrier protein] + CoA
-
tetradecanoyl-CoA and cis-9-hexadecenoyl-CoA are poor substrates
-
r
acyl-CoA + [acyl-carrier protein]
acyl-[acyl-carrier protein] + CoA
-
catalyzes fatty acyl transfer between CoA and [acyl-carrier-protein], but no direct transfer to the enzyme as with acyl-[acyl-carrier-protein]
-
-
?
acyl-CoA + [acyl-carrier protein]
acyl-[acyl-carrier protein] + CoA
-
catalyzes fatty acyl transfer between CoA and [acyl-carrier-protein], but no direct transfer to the enzyme as with acyl-[acyl-carrier-protein]
-
r
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
initiation of fatty acid biosynthesis with acetyl-CoA as a primer, overview substrate specificity
-
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
involved in biosynthesis of saturated fatty acids
-
-
r
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
involved in biosynthesis of unsaturated and saturated fatty acids
-
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
part of non-associated fatty acid synthase system of plants and prokaryotes
-
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
responsible for chain elongation during de novo fatty acid synthesis
-
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
key enzyme for regulation of medium-chain fatty acid synthesis in seeds
-
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
part of non-associated fatty acid synthase system of plants and prokaryotes
-
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
part of non-associated fatty acid synthase system of plants and prokaryotes
-
-
ir
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
part of non-associated fatty acid synthase system of plants and prokaryotes
-
-
r
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
involved in biosynthesis of saturated fatty acids
-
-
ir
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
involved in biosynthesis of saturated fatty acids
-
-
r
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
involved in biosynthesis of unsaturated and saturated fatty acids
-
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
responsible for chain elongation during de novo fatty acid synthesis
-
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
involved in biosynthesis of mono-unsaturated long-chain fatty acids
-
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
C4 to C14 acyl-[ACP]s, the enzyme readily elongates C4:0-through C10:0-PfACPs, has significantly less activity with C12:0- and C14:0-ACPs, and no capacity for elongation of C16:0-ACP and C18:0-ACP
-
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
part of non-associated fatty acid synthase system of plants and prokaryotes
-
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
involved in biosynthesis of saturated fatty acids
-
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
initiation of fatty acid biosynthesis
-
-
ir
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
part of fatty acid synthase II
-
-
ir
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
initiation of both straight- and branched-chain fatty acid biosynthesis resulting in a wide variety of produced fatty acids in vivo
-
-
?
an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]
a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
-
-
?
an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]
a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
-
-
?
an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]
a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
-
-
?
an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]
a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
-
-
?
an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]
a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
-
-
-
?
an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]
a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
-
-
?
an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]
a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
-
-
?
an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]
a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
-
-
?
an acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
a 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
the endoplasmic reticulum enzyme is involved in synthesis of very long chain fatty acids
-
-
?
an acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
a 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
KCS-I displays a preference for 20:0-CoA, substrate specificity, overview
-
-
?
butyryl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
beta-ketohexanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
ir
butyryl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
beta-ketohexanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
synthase III
-
-
?
butyryl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
beta-ketohexanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
synthase III
-
-
?
cis-3-decenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxo-cis-5-dodecenoyl-[acyl-carrier protein] + acyl-carrier protein
-
-
-
-
?
cis-3-decenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxo-cis-5-dodecenoyl-[acyl-carrier protein] + acyl-carrier protein
-
key step in the unsaturated fatty acid, UFA, synthesis pathway. FabB is negatively regulated by the FabR protein
the product is not incorporated into the complex lipids of the bacterium
-
?
cis-9-hexadecenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxo-cis-11-octadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
cis-9-hexadecenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxo-cis-11-octadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
r
cis-9-hexadecenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxo-cis-11-octadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
poor substrate, synthase I
-
-
?
cis-9-hexadecenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxo-cis-11-octadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
poor substrate, synthase I
-
-
r
cis-9-hexadecenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxo-cis-11-octadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
best substrate, synthase II
-
-
?
cis-9-hexadecenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxo-cis-11-octadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
best substrate, synthase II
-
-
r
cis-9-hexadecenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxo-cis-11-octadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
poor substrate, synthase I
-
-
r
cis-mono-unsaturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
cis-mono-unsaturated 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
cis-mono-unsaturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
cis-mono-unsaturated 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
cis-mono-unsaturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
cis-mono-unsaturated 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
not cis-vaccenoyl-[acyl-carrier-protein], i.e. cis-11-octenoyl-[acyl-carrier-protein]
-
-
?
cis-mono-unsaturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
cis-mono-unsaturated 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
not cis-vaccenoyl-[acyl-carrier-protein], i.e. cis-11-octenoyl-[acyl-carrier-protein]
-
-
r
cis-mono-unsaturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
cis-mono-unsaturated 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
from C-10 to C-16, e.g. cis-5-decenoyl-[acyl-carrier-protein], cis-5-dodecenoyl-[acyl-carrier-protein], cis-7-tetradecenoyl-[acyl-carrier-protein], cis-9-hexenoyl-[acyl-carrier-protein], i.e. palmitoleoyl-[acyl-carrier-protein], poor substrates
-
-
?
cis-mono-unsaturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
cis-mono-unsaturated 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
from C-10 to C-16, e.g. cis-5-decenoyl-[acyl-carrier-protein], cis-5-dodecenoyl-[acyl-carrier-protein], cis-7-tetradecenoyl-[acyl-carrier-protein], cis-9-hexenoyl-[acyl-carrier-protein], i.e. palmitoleoyl-[acyl-carrier-protein], poor substrates
-
-
r
cis-mono-unsaturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
cis-mono-unsaturated 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
from C-10 to C-16, e.g. cis-5-decenoyl-[acyl-carrier-protein], cis-5-dodecenoyl-[acyl-carrier-protein], cis-7-tetradecenoyl-[acyl-carrier-protein], cis-9-hexenoyl-[acyl-carrier-protein], i.e. palmitoleoyl-[acyl-carrier-protein], poor substrates
-
-
?
decanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
dodecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
synthase IV
-
-
?
decanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
dodecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
decanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
dodecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
decanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
dodecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
decanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
dodecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
decanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
dodecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
synthase I
-
-
?
dodecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxotetradecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
dodecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxotetradecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
dodecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxotetradecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
dodecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxotetradecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
hexadecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
i.e. palmitoyl-[acyl-carrier-protein]
-
-
?
hexadecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
hexadecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
i.e. palmitoyl-[acyl-carrier-protein]
-
-
?
hexadecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
poor substrate
-
-
?
hexadecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
only synthase II, best substrate
-
-
?
hexadecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
i.e. palmitoyl-[acyl-carrier-protein]
-
-
?
hexadecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
preferred substrate, synthase III
-
-
?
hexanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
hexanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
ir
hexanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
r
hexanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
characterization of hexanoyl-enzyme intermediate
-
-
r
hexanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
hexanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
hexanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
hexanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
best substrate, synthase I
-
-
?
hexanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
isobutyryl-CoA + malonyl-[acyl-carrier protein]
?
synthase III
-
-
?
isobutyryl-CoA + malonyl-[acyl-carrier protein]
?
-
synthase III
-
-
?
isobutyryl-CoA + malonyl-[acyl-carrier protein]
?
-
isobutyryl-CoA is a precursor of branched-chain fatty acid synthesis
-
-
?
malonyl-[acyl-carrier protein]
acetyl-[acyl-carrier protein] + CO2
-
catalyzes malonyl-[acyl-carrier-protein] decarboxylation independent of fatty acyl-[acyl-carrier-protein]
-
?
malonyl-[acyl-carrier protein]
acetyl-[acyl-carrier protein] + CO2
-
decarboxylation with 2-3% the rate of beta-ketoacyl-[acyl-carrier-protein]-synthesis
-
?
malonyl-[acyl-carrier protein]
acetyl-[acyl-carrier protein] + CO2
-
wild-type synthase I and mutants C163A and C163S
-
?
malonyl-[acyl-carrier protein]
acetyl-[acyl-carrier protein] + CO2
-
-
-
-
?
myristoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxohexadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
myristoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxohexadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
octadecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoeicosanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
synthase I and II
-
-
?
octadecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoeicosanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
octanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxodecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
ir
octanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxodecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
r
octanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxodecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
octanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxodecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
octanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxodecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
palmitoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
palmitoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
propionyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
beta-ketopentanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
ir
propionyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
beta-ketopentanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
absolutely specific for
-
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
synthase II, parenchyma and lamina epidermis: palmitoyl-[acyl-carrier-protein] is the only product, sheath epidermis: acyl-[acyl-carrier-protein] up to C22 chain length
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
substrate specificity, overview
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
r
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
fatty acid composition of Brassica napus wild-type and transgenic plants overexpressing the E. coli synthase III
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
substrate specificity, overview
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
preference for medium-chain length [acyl-carrier-protein]-substrates, synthase IV
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
r
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
r
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
substrate specificity, overview
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
substrate specificity, overview
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
substrate specificity, overview
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
substrate specificity, overview
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
substrate specificity, overview
-
ir
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
substrate specificity, overview
-
r
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
substrate specificity, overview
-
r
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
not hexadecanoyl-[acyl-carrier-protein]
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
not hexadecanoyl-[acyl-carrier-protein]
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
specific for acyl-[acyl-carrier-protein] thioesters, not acyl-CoA or acyl pantetheine thioesters
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
specific for acyl-[acyl-carrier-protein] thioesters, not acyl-CoA or acyl pantetheine thioesters
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
fatty acid composition of Brassica napus wild-type and transgenic plants overexpressing the E. coli synthase III
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
substrate specificity, overview
-
r
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
substrate specificity, overview
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
r
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
substrate specificity, overview
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
substrate specificity, overview
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
not octodecanoyl-[acyl-carrier-protein], i.e stearoyl-[acyl-carrier-protein]
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
not octodecanoyl-[acyl-carrier-protein], i.e stearoyl-[acyl-carrier-protein]
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
ir
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
substrate specificity, overview
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
substrate specificity, overview
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
substrate specificity, overview
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
synthase III, broad specificity
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
synthase III, broad specificity
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
r
tetradecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxohexadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
tetradecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxohexadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
poor substrate
-
-
r
tetradecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxohexadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
synthase I
-
-
?
tetradecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxohexadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
tetradecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxohexadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
i.e. myristoyl-[acyl-carrier-protein], only synthase II
-
-
?
additional information
?
-
no substrate: acetyl-[acyl-carrier protein]
-
-
?
additional information
?
-
-
no substrate: acetyl-[acyl-carrier protein]
-
-
?
additional information
?
-
-
synthase III isozymes also utilize iso- and anteiso-branched-chain acyl-CoA primers as substrates
-
-
?
additional information
?
-
the enzyme has a preference for catalyzing the elongation of C4:0 to C14:0 on acyl-carrier protein
-
-
-
additional information
?
-
-
-
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
enzyme also catalyzes a malonyl-CoA-CO2 exchange reaction, overview: substrates and kinetics
-
-
?
additional information
?
-
-
synthase I and II have nearly the same substrate specificity
-
-
?
additional information
?
-
-
enzyme active site structure of wild-type and mutants with or without bound C12 or C8, overview
-
-
?
additional information
?
-
-
synthase I and II have nearly the same substrate specificity
-
-
?
additional information
?
-
-
important role in generation of the lipoic acid precursor octanoyl-acyl-carrier protein
-
-
?
additional information
?
-
-
preference for acyl-[acyl-carrier protein] in decreasing order: C12, C10, C6, C8, C4, C2, C14, C16
-
-
?
additional information
?
-
KAS catalyzes the C2 fatty acid elongation reaction using a Cys-His-His catalytic triad
-
-
?
additional information
?
-
-
KAS catalyzes the C2 fatty acid elongation reaction using a Cys-His-His catalytic triad
-
-
?
additional information
?
-
-
enzyme is able to use Escherichia coli acyl-carrier protein. Enzyme extends longer, physiologically relevant acyl-CoA primers when paired with its native acyl-carrier protein than with Escherichia coli acyl-carrier protein
-
-
?
additional information
?
-
-
synthase I is specific for short-chain fatty acid prolongation while synthase II is active in C18 formation from C16
-
-
?
additional information
?
-
-
rank of activity in decreasing order: isobutyryl-CoA, hexanoyl-CoA, butyryl-CoA, isovaleryl-CoA, acetyl-CoA
-
-
?
additional information
?
-
-
inhibition of FabH leads to loss of accumulation of acetoacetyl-ACP
-
-
?
additional information
?
-
-
FabH produces C14 long-chain beta-ketoacyl-ACP
-
-
?
additional information
?
-
synthase III, FabH, has a preference for straight short-chain CoA primers
-
-
?
additional information
?
-
-
malonyl-CoA-CO2 exchange reaction
-
-
?
additional information
?
-
the organism, with the unusual lipid metabolism of the trypanosome, uses a microsomal elongase pathway, ELO, for de novo fatty acid synthesis, a second FAS pathway with a type II synthase is localized to the mitochondrion and is essential for bloodstream and procyclic life cycle stages of the parasite, in vivo precursors of mitochondrial fatty acid synthesis, overview
-
-
?
additional information
?
-
-
the organism, with the unusual lipid metabolism of the trypanosome, uses a microsomal elongase pathway, ELO, for de novo fatty acid synthesis, a second FAS pathway with a type II synthase is localized to the mitochondrion and is essential for bloodstream and procyclic life cycle stages of the parasite, in vivo precursors of mitochondrial fatty acid synthesis, overview
-
-
?
additional information
?
-
octanoate, the precursor for lipoic acid synthesis, is also produced by the mitochondrial FAS
-
-
?
additional information
?
-
-
octanoate, the precursor for lipoic acid synthesis, is also produced by the mitochondrial FAS
-
-
?
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(5-thiophen-2-ylisoxazol-3-yl)methanol
-
4-phenyl-5-phenylimino-[1,2,4]dithiazolidin-3-one
i.e. HR19; strong, synthase III
5-chloro-4-phenyl-[1,2]-dithiol-3-one
complete inhibition at 0.01 nM, synthase III; i.e. HR12
acyl-CoA
-
at high concentrations
butyryl-CoA
-
synthase III mutants C122Aand C122Q: inhibition of decarboxylation activity in presence of
C75
-
a synthetic inhibitor of fatty acid synthase, inhibits also the beta-ketoacyl synthase, not in simple first order rate reaction, C75 is a competitive, irreversible inhibitor of the overall reaction, the beta-ketoacyl synthase activity and the enoyl reductase activity substrates do not protect the thioesterase activity of rat liver FAS from inactivation by C75, but malonyl-CoA and acetyl-CoA protect the FAS beta-ketoacyl synthase reaction from inactivation by C75 in a competitive manner, overview
genistein
5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one
isobutyryl-CoA
-
synthase III mutants C122Aand C122Q: inhibition of decarboxylation activity in presence of
isorhamnetin
3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)chromen-4-one
N-(3-pyridinyl)-hexanamide
result of an in silicio screening, antimicrobial activity, binding to beta-ketoacyl-[acyl-carrier-protein] synthase I characterized by saturation-transfer difference NMR spectroscopy
p-chloromercuribenzoate
-
complete inhibition at 1 mM
palmitoyl-CoA
-
substrate inhibition above 0.003 mM
thiolactomicin
thiolactomycin is an inhibitor of KAS I and inhibits bacterial cell growth through inhibition of the beta-ketoacyl-ACP synthase activity of type II fatty acids ynthases
Urea
-
about 50% inhibition at 1 M, complete inactivation at 4 M
[Acyl-carrier-protein]
-
wild-type synthase I and mutants, not mutants C163S and K328A, overview
arsenite
-
-
arsenite
-
synthase II and I
cerulenin
-
synthase II, moderate
cerulenin
-
no inhibition
cerulenin
-
analysis of the binding mechanism, mimicks the condensation transition state; FabB: inhibition is irreversible
cerulenin
forms two hydrogen bonding interactions with H333 and backbone amide hydrogen of G391 and a hydrophobic interaction with M197, F229, and F231
cerulenin
irreversible inhibitor of beta-ketoacyl-ACP synthases I and II but is not a selective anti-bacterial because it is also a potent inhibitor of the condensation reaction catalyzed by the mammalian multifunctional (type I) fatty-acidsynthase
cerulenin
-
50% inhibition at 0.2 mM
cerulenin
-
irreversible inhibition, IC50: 0.0158 mM
cerulenin
-
specific inhibition of the enzyme
cerulenin
-
antibiotic, protection by hexanoyl-[acyl-carrier-protein], decanoyl-[acyl-carrier-protein], and tetradecanoyl-[acyl-carrier-protein]
cerulenin
weak, synthase III
cerulenin
-
12-carbon mycotoxin, irreversible inhibition, binding motif; at 0.05 mM: wild-type is completely inactivated, mutant I108F and A193M show only 10% reduced activity
iodoacetamide
-
no inhibition of malonyl-[acyl-carrier-protein]-decarboxylation
iodoacetamide
-
acyl-[acyl-carrier-protein]-derivatives, e.g. acetyl-[acyl-carrier-protein], hexanoyl-CoA, octanoyl-CoA, decanoyl-CoA protect
iodoacetamide
-
after incubation with 2-mercaptethanol
iodoacetamide
-
acyl-[acyl-carrier-protein]-derivatives, e.g. acetyl-[acyl-carrier-protein], hexanoyl-CoA, octanoyl-CoA, decanoyl-CoA protect
iodoacetamide
-
acyl-[acyl-carrier-protein]-derivatives, e.g. acetyl-[acyl-carrier-protein], hexanoyl-CoA, octanoyl-CoA, decanoyl-CoA protect; synthase I and II
N-ethylmaleimide
-
no inhibition of malonyl-[acyl-carrier-protein]-decarboxylation
N-ethylmaleimide
-
no inhibition of malonyl-[acyl-carrier-protein]-decarboxylation
N-ethylmaleimide
-
acyl-[acyl-carrier-protein]-derivatives protect
N-ethylmaleimide
-
after incubation with 2-mercaptoethanol
platencin
-
platencin
-
exhibits a broad-spectrum Gram-positive antibacterial activity through inhibition of fatty acid biosynthesis, targets the two essential proteins, beta-ketoacyl-[acyl carrier protein] synthase II and III, i.e. FabF and FabH, purified FabH IC50: 0.016 mM, overview
platensimycin
-
SB418011
-
-
SB418011
strong, synthase III
thiolactomycin
-
thiolactomycin
-
synthase III
thiolactomycin
-
analysis of the binding mechanism, mimics malonyl-[acyl-carrier-protein]; FabB: inhibition is reversible, competitive
thiolactomycin
forms a hydrogen bonding with H333 and a hydrophobic interaction of Phe229 and Thr300 with ecKAS I
thiolactomycin
-
competitive inhibition, IC50: 0.0236 mM
thiolactomycin
synthase III; weak
thiolactomycin
synthase III; weak
thiolactomycin
-
synthase III
additional information
-
inhibitor screening of 250000 synthetic compounds, enzyme-inhibitor binding study by NMR spectroscopy, three-dimensional structure of ecKAS I with inhibitors, overview. No or poor inhibition by 2-(2-methylanilino)-N'-[(E)-(6-methylpyridin-2-yl)methylidene]propanehydrazide, (5Z)-5-([4-[(propan-2-yl)oxy]phenyl]methylidene)-3-(prop-2-en-1-yl)-1,3-thiazolidine-2,4-dione, 1-[2-[4-(2-ethoxyethyl)piperazin-1-yl]-2-oxoethyl]pyrrolidin-2-one, 2-(hexylcarbamoyl)cyclohexane-1-carboxylic acid, 2-[(4-methylbenzene-1-sulfonyl)methyl]prop-2-enamide, 2-([(E)-[(3-nitrophenyl)methylidene]amino]oxy)propanoic acid, 2-[4-(furan-2-yl)phenoxy]-2-methylpropanoic acid, and N-(3-pyridinyl) hexanamide, the latter is though active against Staphylococcus aureus and Enterococcus faecalis
-
additional information
inhibitor screening of 250000 synthetic compounds, enzyme-inhibitor binding study by NMR spectroscopy, three-dimensional structure of ecKAS I with inhibitors, overview. No or poor inhibition by 2-(2-methylanilino)-N'-[(E)-(6-methylpyridin-2-yl)methylidene]propanehydrazide, (5Z)-5-([4-[(propan-2-yl)oxy]phenyl]methylidene)-3-(prop-2-en-1-yl)-1,3-thiazolidine-2,4-dione, 1-[2-[4-(2-ethoxyethyl)piperazin-1-yl]-2-oxoethyl]pyrrolidin-2-one, 2-(hexylcarbamoyl)cyclohexane-1-carboxylic acid, 2-[(4-methylbenzene-1-sulfonyl)methyl]prop-2-enamide, 2-([(E)-[(3-nitrophenyl)methylidene]amino]oxy)propanoic acid, 2-[4-(furan-2-yl)phenoxy]-2-methylpropanoic acid, and N-(3-pyridinyl) hexanamide, the latter is though active against Staphylococcus aureus and Enterococcus faecalis
-
additional information
screening of 50 flavonoids for inhibition potency against the enzyme, in silico molecular docking study, overview. Only genistein and isorhamnetin show inhibition as well as drug likeliness and bioavailability obeying the Lipinski's guidelines of five. No or poor effects by daidzein, luteolin, herbacetin, petunidin, herbacetin, malvidin, casticin, pinocembrin, kaempferol, butin, 7,3',4',5'-tetramethoxyflavanone, sternbin, galangin, dihydrooroxylin, naringenin, hispidulin, prunetin, 3,6-dihydroxyflavone, tricin, hesperetin, dihydroechioidinin 5,7-dihydroxytrimethoxyflavanone, liquiritigenin, diosmetin, isosakuranetin, dihydrowogonin, syringetin, chrysin, cajanin, naringenin trimethyl ether, pectolinarigenin, 3',4',5',5,7-pentamethoxyflavanone, glycitein, tectorigenin, 4'-hydroxy-5,6,7-trimethoxyflavanone, naringenin 5-methyl ether, 6,2',4'-trimethoxyflavanone, naringenin 7,4'-dimethyl ether, 7-hydroxyflavanone, 5,7-dihydroxyisoflavone, onysilin, and biochanin A
-
additional information
-
screening of 50 flavonoids for inhibition potency against the enzyme, in silico molecular docking study, overview. Only genistein and isorhamnetin show inhibition as well as drug likeliness and bioavailability obeying the Lipinski's guidelines of five. No or poor effects by daidzein, luteolin, herbacetin, petunidin, herbacetin, malvidin, casticin, pinocembrin, kaempferol, butin, 7,3',4',5'-tetramethoxyflavanone, sternbin, galangin, dihydrooroxylin, naringenin, hispidulin, prunetin, 3,6-dihydroxyflavone, tricin, hesperetin, dihydroechioidinin 5,7-dihydroxytrimethoxyflavanone, liquiritigenin, diosmetin, isosakuranetin, dihydrowogonin, syringetin, chrysin, cajanin, naringenin trimethyl ether, pectolinarigenin, 3',4',5',5,7-pentamethoxyflavanone, glycitein, tectorigenin, 4'-hydroxy-5,6,7-trimethoxyflavanone, naringenin 5-methyl ether, 6,2',4'-trimethoxyflavanone, naringenin 7,4'-dimethyl ether, 7-hydroxyflavanone, 5,7-dihydroxyisoflavone, onysilin, and biochanin A
-
additional information
-
the enzyme shows strong substrate inhibition
-
additional information
inhibitor binding structure determination
-
additional information
-
inhibitor binding structure determination
-
additional information
-
in vivo inhibition assays, no inhibition by platensimycin
-
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Shimakata, T.; Stumpf, P.K.
The procaryotic nature of the fatty acid synthetase of developing Carthamus tinctorius L. (Safflower) seeds
Arch. Biochem. Biophys.
217
144-154
1982
Carthamus tinctorius
brenda
Shimakata, T.; Stumpf, P.K.
The purification and function of acetyl coenzyme A:acyl carrier protein transacylase
J. Biol. Chem.
258
3592-3598
1983
Brassica juncea, Carthamus tinctorius, Cuphea lutea, Pisum sativum, Spinacia oleracea
brenda
Hendren, R.W.; Bloch, K.
Fatty acid synthetases from Euglena gracilis. Separation of component activities of the ACP-dependent fatty acid synthetase and partial purification of the beta-ketoacyl-ACP synthetase
J. Biol. Chem.
255
1504-1508
1980
Euglena gracilis, Euglena gracilis Z
brenda
Vagelos, R.P.
Acyl group transfer (acyl carrier protein)
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
8
155-199
1973
Clostridium kluyveri, Escherichia coli
-
brenda
Prescott, D.J.; Vagelos, P.R.
Acyl carrier protein
Adv. Enzymol. Relat. Areas Mol. Biol.
36
269-311
1972
Escherichia coli
brenda
Toomey, R.E.; Wakil, S.J.
Studies on the mechanism of fatty acid synthesis. XVI. Preparation and general properties of acyl-malonyl acyl carrier protein-condensing enzyme from Escherichia coli
J. Biol. Chem.
241
1159-1165
1966
Escherichia coli
brenda
Alberts, A.W.; Majerus, P.W.; Vagelos, P.R.
beta-Ketoacyl acyl carrier protein synthase
Methods Enzymol.
14
57-60
1969
Escherichia coli
-
brenda
Garwin, J.L.; Klages, A.L.; Cronan, J.E.
Structural, enzymatic, and genetic studies of beta-ketoacyl-acyl carrier protein synthases I and II of Escherichia coli
J. Biol. Chem.
255
11949-11956
1980
Escherichia coli
brenda
Alberts, A.W.; Bell, R.M.; Vagelos, P.R.
Acyl carrier protein. XV. Studies of beta-ketoacyl-acyl carrier protein synthetase
J. Biol. Chem.
247
3190-3198
1972
Escherichia coli
brenda
D'Agnolo, G.; Rosenfeld, I.S.; Vagelos, P.R.
beta-Ketoacyl-acyl carrier protein synthetase. Characterization of the acyl-enzyme intermediate
J. Biol. Chem.
250
5283-5288
1975
Escherichia coli
brenda
D'Agnolo, G.; Rosenfeld, I.S.; Vagelos, P.R.
Multiple forms of beta-ketoacyl-acyl carrier protein synthetase in Escherichia coli
J. Biol. Chem.
250
5289-5294
1975
Escherichia coli, Escherichia coli B / ATCC 11303
brenda
Shimakata, T.; Stumpf, P.L.
Purification and characterization of beta-ketoacyl-[acyl-carrier-protein] synthetase I from Spinacia oleracea leaves
Arch. Biochem. Biophys.
220
39-45
1983
Spinacia oleracea
brenda
Schuz, R.; Ebel, J.; Hahlbrock, K.
Partial purification of beta-ketoacyl-acyl acrrier protein synthase from a higher plant
FEBS Lett.
140
207-209
1982
Petroselinum crispum
-
brenda
MacKintosh, R.W.; Hardie, D.G.; Slabas, A.R.
beta-Ketoacyl-acyl-carrier protein synthase from developing seeds of oilseed rape (Brassica napus)
Biochem. Soc. Trans.
17
686-687
1989
Brassica napus
-
brenda
MacKintosh, R.W.; Hardie, D.G.; Slabas, A.R.
A new assay procedure to study the induction of beta-ketoacyl-ACP synthase I and II, and the complete purification of beta-ketoacyl-ACP synthase I from developing seeds of oilseed rape (Brassica napus)
Biochim. Biophys. Acta
1002
114-124
1989
Brassica napus
-
brenda
Shimakata, T.; Stumpf, P.L.
Isolation and function of spinach leaf beta-ketoacyl-[acyl-carrier-protein] synthases
Proc. Natl. Acad. Sci. USA
79
5808-5812
1982
Spinacia oleracea
brenda
Siggaard-Andersen, M.; Kauppinen, S.; von Wettstein-Knowles, P.
Primary structure of a cerulenin-binding beta-ketoacyl-[acyl carrier protein] synthase from barley chloroplasts
Proc. Natl. Acad. Sci. USA
88
4114-4118
1991
Hordeum vulgare, Spinacia oleracea
brenda
Clough, R.; Matthis, A.L.; Barnum, S.R.; Jaworski, J.G.
Purification and characterization of 3-ketoacyl-acyl carrier protein synthase III from spinach. A condensing enzyme utilizing acetyl-coenzyme A to initiate fatty acid synthesis
J. Biol. Chem.
267
20992-20998
1992
Spinacia oleracea
brenda
Verwoert, I.I.G.S.; van der Linden, K.H.; Walsh, M.C.; Nijkamp, H.J.J.; Stuitje, A.R.
Modification of Brassica napus seed oil by expression of the Escherichia coli fabH gene, encoding 3-ketoacyl-acyl carrier protein synthase III
Plant Mol. Biol.
27
875-886
1995
Brassica napus, Escherichia coli
brenda
Han, L.; Lobo, S.; Reynolds, K.A.
Characterization of beta-ketoacyl-acyl carrier protein synthase III from Streptomyces glaucescens and its role in initiation of fatty acid biosynthesis
J. Bacteriol.
180
4481-4486
1998
Streptomyces glaucescens
brenda
Bao, W.; Sheldon, P.J.; Hutchinson, C.R.
Purification and properties of the Streptomyces peucetius DpsC beta-ketoacyl:acyl carrier protein synthase III that specifies the propionate-starter unit for type II polyketide biosynthesis
Biochemistry
38
9752-9757
1999
Streptomyces peucetius
brenda
Domergue, F.; Post-Beittenmiller, D.
Biochemical characterization of 3-ketoacyl-acyl carrier protein synthase II from leek epidermis
Biochem. Soc. Trans.
28
610-613
2000
Allium ampeloprasum
brenda
Val, D.; Banu, G.; Seshadri, K.; Lindqvist, Y.; Dehesh, K.
Re-engineering ketoacyl synthase specificity
Structure
8
565-566
2000
Synechocystis sp.
brenda
Choi, K.H.; Heath, R.J.; Rock, C.O.
beta-ketoacyl-acyl carrier protein synthase III (FabH) is a determining factor in branched-chain fatty acid biosynthesis
J. Bacteriol.
182
365-370
2000
Bacillus subtilis, Escherichia coli
brenda
Smirnova, N.; Reynolds, K.A.
Engineered fatty acid biosynthesis in Streptomyces by altered catalytic function of beta-ketoacyl-acyl carrier protein synthase III
J. Bacteriol.
183
2335-2342
2001
Streptomyces glaucescens
brenda
Khandekar, S.S.; Gentry, D.R.; Van Aller, G.S.; Warren, P.; Xiang, H.; Silverman, C.; Doyle, M.L.; Chambers, P.A.; Konstantinidis, A.K.; Brandt, M.; Daines, R.A.; Lonsdale, J.T.
Identification, substrate specificity, and inhibition of the Streptococcus pneumoniae beta-ketoacyl-acyl carrier protein synthase III (FabH)
J. Biol. Chem.
276
30024-30030
2001
Escherichia coli, Haemophilus influenzae, Streptococcus pneumoniae (P0A3C5)
brenda
Moche, M.; Dehesh, K.; Edwards, P.; Lindqvist, Y.
The crystal structure of beta-ketoacyl-acyl carrier protein synthase II from Synechocystis sp. at 1.54.ANG. resolution and its relationship to other condensing enzymes
J. Mol. Biol.
305
491-503
2001
Synechocystis sp.
brenda
Price, A.C.; Choi, K.H.; Heath, R.J.; Li, Z.; White, S.W.; Rock, C.O.
Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism
J. Biol. Chem.
276
6551-6559
2001
Escherichia coli
brenda
McGuire, K.A.; Siggaard-Andersen, M.; Bangera, M.G.; Olsen, J.G.; von Wettstein-Knowles, P.
beta-Ketoacyl-[acyl carrier protein] synthase I of Escherichia coli: aspects of the condensation mechanism revealed by analyses of mutations in the active site pocket
Biochemistry
40
9836-9845
2001
Escherichia coli
brenda
Witkowski, A.; Joshi, A.K.; Smith, S.
Mechanism of the beta-ketoacyl synthase reaction catalyzed by the animal fatty acid synthase
Biochemistry
41
10877-10887
2002
Rattus norvegicus
brenda
He, X.; Reynolds, K.A.
Purification, characterization, and identification of novel inhibitors of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus
Antimicrob. Agents Chemother.
46
1310-1318
2002
Staphylococcus aureus (P99159)
brenda
Schutt, B.S.; Abbadi, A.; Loddenkotter, B.; Brummel, M.; Spener, F.
beta-Ketoacyl-acyl carrier protein synthase IV: a key enzyme for regulation of medium-chain fatty acid synthesis in Cuphea lanceolata seeds
Planta
215
847-854
2002
Cuphea lanceolata
brenda
Mekhedov, S.; Cahoon, E.B.; Ohlrogge, J.
An unusual seed-specific 3-ketoacyl-ACP synthase associated with the biosynthesis of petroselinic acid in coriander
Plant Mol. Biol.
47
507-518
2001
Coriandrum sativum
brenda
Olsen, J.G.; Rasmussen, A.V.; von Wettstein-Knowles, P.; Henriksen, A.
Structure of the mitochondrial beta-ketoacyl-[acyl carrier protein] synthase from Arabidopsis and its role in fatty acid synthesis
FEBS Lett.
577
170-174
2004
Arabidopsis thaliana (Q8L3X9), Arabidopsis thaliana
brenda
Price, A.C.; Rock, C.O.; White, S.W.
The 1.3-Angstrom-resolution crystal structure of beta-ketoacyl-acyl carrier protein synthase II from Streptococcus pneumoniae
J. Bacteriol.
185
4136-4143
2003
Streptococcus pneumoniae
brenda
Lai, C.Y.; Cronan, J.E.
beta-Ketoacyl-acyl carrier protein synthase III (FabH) is essential for bacterial fatty acid synthesis
J. Biol. Chem.
278
51494-51503
2003
Lactococcus lactis
brenda
Yasuno, R.; von Wettstein-Knowles, P.; Wada, H.
Identification and molecular characterization of the beta-ketoacyl-[acyl carrier protein] synthase component of the Arabidopsis mitochondrial fatty acid synthase
J. Biol. Chem.
279
8242-8251
2004
Arabidopsis thaliana (Q8L3X9), Arabidopsis thaliana
brenda
Zhang, L.; Joshi, A.K.; Hofmann, J.; Schweizer, E.; Smith, S.
Cloning, expression, and characterization of the human mitochondrial beta-ketoacyl synthase. Complementation of the yeast CEM1 knock-out strain
J. Biol. Chem.
280
12422-12429
2005
Homo sapiens
brenda
Brown, A.K.; Sridharan, S.; Kremer, L.; Lindenberg, S.; Dover, L.G.; Sacchettini, J.C.; Besra, G.S.
Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-ACP synthase III mtFabH: Factors influencing catalysis and substrate specificity
J. Biol. Chem.
280
32539-32547
2005
Mycobacterium tuberculosis
brenda
Musayev, F.; Sachdeva, S.; Scarsdale, J.N.; Reynolds, K.A.; Wright, H.T.
Crystal structure of a substrate complex of Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III (FabH) with lauroyl-coenzyme A
J. Mol. Biol.
346
1313-1321
2005
Mycobacterium tuberculosis
brenda
Kursula, P.; Sikkilae, H.; Fukao, T.; Kondo, N.; Wierenga, R.K.
High resolution crystal structures of human cytosolic thiolase (CT): A comparison of the active sites of human CT, bacterial thiolase, and bacterial KAS I
J. Mol. Biol.
347
189-201
2005
Escherichia coli (P0A953), Escherichia coli
brenda
Qiu, X.; Choudhry, A.E.; Janson, C.A.; Grooms, M.; Daines, R.A.; Lonsdale, J.T.; Khandekar, S.S.
Crystal structure and substrate specificity of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus
Protein Sci.
14
2087-2094
2005
Staphylococcus aureus
brenda
Dawe, J.H.; Porter, C.T.; Thornton, J.M.; Tabor, A.B.
A template search reveals mechanistic similarities and differences in beta-ketoacyl synthases (KAS) and related enzymes
Proteins
52
427-435
2003
Escherichia coli
brenda
Rendina, A.R.; Cheng, D.
Characterization of the inactivation of rat fatty acid synthase by C75: inhibition of partial reactions and protection by substrates
Biochem. J.
388
895-903
2005
Rattus norvegicus
brenda
von Wettstein-Knowles, P.; Olsen, J.G.; McGuire, K.A.; Henriksen, A.
Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases
FEBS J.
273
695-710
2006
Escherichia coli
brenda
Salas, J.J.; Martinez-Force, E.; Garces, R.
Very long chain fatty acid synthesis in sunflower kernels
J. Agric. Food Chem.
53
2710-2716
2005
Helianthus annuus
brenda
Lack, G.; Homberger-Zizzari, E.; Folkers, G.; Scapozza, L.; Perozzo, R.
Recombinant expression and biochemical characterization of the unique elongating beta-ketoacyl-acyl carrier protein synthase involved in fatty acid biosynthesis of Plasmodium falciparum using natural and artificial substrates
J. Biol. Chem.
281
9538-9546
2006
Plasmodium falciparum
brenda
Stephens, J.L.; Lee, S.H.; Paul, K.S.; Englund, P.T.
Mitochondrial fatty acid synthesis in Trypanosoma brucei
J. Biol. Chem.
282
4427-4436
2007
Trypanosoma brucei (Q586W9), Trypanosoma brucei
brenda
Wang, J.; Kodali, S.; Lee, S.H.; Galgoci, A.; Painter, R.; Dorso, K.; Racine, F.; Motyl, M.; Hernandez, L.; Tinney, E.; Colletti, S.L.; Herath, K.; Cummings, R.; Salazar, O.; Gonzalez, I.; Basilio, A.; Vicente, F.; Genilloud, O.; Pelaez, F.; Jayasuriya, H.; Young, K.; Cully, D.F.; Singh, S.B.
Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties
Proc. Natl. Acad. Sci. USA
104
7612-7616
2007
Staphylococcus aureus
brenda
Christensen, C.E.; Kragelund, B.B.; von Wettstein-Knowles, P.; Henriksen, A.
Structure of the human beta-ketoacyl [ACP] synthase from the mitochondrial type II fatty acid synthase
Protein Sci.
16
261-272
2007
Homo sapiens (Q9NWU1), Homo sapiens
brenda
Feng, Y.; Cronan, J.E.
Escherichia coli unsaturated fatty acid synthesis: complex transcription of the fabA gene and in vivo identification of the essential reaction catalyzed by FabB
J. Biol. Chem.
284
29526-29535
2009
Escherichia coli
brenda
Doan, T.; Kim, J.; Mac, Q.; Chung, C.; Sampath, N.; Kim, J.; Ahn, Y.; Kang, L.
Crystallization and preliminary X-ray crystallographic analysis of beta-ketoacyl-ACP synthase I (XoFabB) from Xanthomonas oryzae pv. oryzae
Acta Crystallogr. Sect. F
67
1548-1550
2011
Xanthomonas oryzae pv. oryzae
brenda
Borgaro, J.; Chang, A.; MacHutta, C.; Zhang, X.; Tonge, P.
Substrate recognition by beta-ketoacyl-ACP synthases
Biochemistry
50
10678-10686
2011
Escherichia coli, Mycobacterium tuberculosis
brenda
Lee, J.; Jeong, K.; Lee, J.; Kang, D.; Kim, Y.
In silico screening of a novel inhibitor of beta-ketoacyl acyl carrier protein synthase i
Bull. Korean Chem. Soc.
32
1645-1649
2011
Escherichia coli, Escherichia coli (E2QPI4)
-
brenda
Wu, G.; Xue, H.
Arabidopsis beta-ketoacyl-[acyl carrier protein] synthase I is crucial for fatty acid synthesis and plays a role in chloroplast division and embryo development
Plant Cell
22
3726-3744
2010
Arabidopsis thaliana (P52410)
brenda
Sabbagh, G.; Berakdar, N.
Docking studies of flavonoid compounds as inhibitors of beta-ketoacyl acyl carrier protein synthase I (Kas I) of Escherichia coli
J. Mol. Graph. Model.
61
214-223
2015
Escherichia coli (E2QPI4), Escherichia coli
brenda
Yuan, Y.; Liang, Y.; Li, B.; Zheng, Y.; Luo, X.; Dongdong, L.
Cloning and function characterization of a beta-ketoacyl-acyl-ACP synthase I from coconut (Cocos nucifera L.) endosperm
Plant Mol. Biol. Rep.
33
1131-1140
2015
Cocos nucifera (V9N3I8)
-
brenda
Ding, W.; Lin, L.; Zhang, B.; Xiang, X.; Wu, J.; Pan, Z.; Zhu, S.
OsKASI, a beta-ketoacyl-[acyl carrier protein] synthase I, is involved in root development in rice (Oryza sativa L.)
Planta
242
203-213
2015
Oryza sativa
brenda
Jayaraman, M.; Rajendra, S.; Ramadas, K.
Structural insight into conformational dynamics of non-active site mutations in KasA A Mycobacterium tuberculosis target protein
Gene
720
144082
2019
Mycobacterium tuberculosis (P9WQD9), Mycobacterium tuberculosis H37Rv (P9WQD9)
brenda
Morvan, C.; Halpern, D.; Kenanian, G.; Pathania, A.; Anba-Mondoloni, J.; Lamberet, G.; Gruss, A.; Gloux, K.
The Staphylococcus aureus FASII bypass escape route from FASII inhibitors
Biochimie
141
40-46
2017
Staphylococcus aureus
brenda
Yang, T.; Xu, R.; Chen, J.; Liu, A.
beta-Ketoacyl-acyl carrier protein synthase I (KASI) plays crucial roles in the plant growth and fatty acids synthesis in tobacco
Int. J. Mol. Sci.
17
1287
2016
Nicotiana tabacum (A0A3G1E3Q4), Nicotiana tabacum (A0A3G1E3S8), Nicotiana tabacum
brenda
Xiong, W.; Wei, Q.; Wu, P.; Zhang, S.; Li, J.; Chen, Y.; Li, M.; Jiang, H.; Wu, G.
Molecular cloning and characterization of two beta-ketoacyl-acyl carrier protein synthase I genes from Jatropha curcas L.
J. Plant Physiol.
214
152-160
2017
Jatropha curcas
brenda
Milligan, J.C.; Lee, D.J.; Jackson, D.R.; Schaub, A.J.; Beld, J.; Barajas, J.F.; Hale, J.J.; Luo, R.; Burkart, M.D.; Tsai, S.C.
Molecular basis for interactions between an acyl carrier protein and a ketosynthase
Nat. Chem. Biol.
15
669-671
2019
Escherichia coli (P0A953)
brenda
Yuan, Y.; Liang, Y.; Li, B.; Zheng, Y.; Luo, X.; Dongdong, L.
Cloning and function characterization of a beta-ketoacyl-acyl-ACP synthase I from coconut (Cocos nucifera L.) endosperm
Plant Mol. Biol. Rep.
33
1131-1140
2015
Cocos nucifera (V9N3I8)
-
brenda
Patterson, E.I.; Nanson, J.D.; Abendroth, J.; Bryan, C.; Sankaran, B.; Myler, P.J.; Forwood, J.K.
Structural characterization of beta-ketoacyl ACP synthase I bound to platencin and fragment screening molecules at two substrate binding sites
Proteins
88
47-56
2020
Brucella melitensis (Q2YQQ9), Brucella melitensis 2308 (Q2YQQ9)
brenda