Literature summary for 2.3.1.41 extracted from

Sabbagh, G.; Berakdar, N.
Docking studies of flavonoid compounds as inhibitors of beta-ketoacyl acyl carrier protein synthase I (Kas I) of Escherichia coli (2015), J. Mol. Graph. Model., 61, 214-223.

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Application

Application	Comment	Organism
drug development	the enzyme is an attractive target for design of antibioticsis related to the elongation of unsat-urated fatty acids in bacterial fatty acid synthesis	Escherichia coli

Inhibitors

Inhibitors	Comment	Organism	Structure
3,6-dihydroxyflavone	-	Escherichia coli
baicalein	-	Escherichia coli
cerulenin	irreversible inhibitor of beta-ketoacyl-ACP synthases I and II but is not a selective anti-bacterial because it is also a potent inhibitor of the condensation reaction catalyzed by the mammalian multifunctional (type I) fatty-acidsynthase	Escherichia coli
daidzein	-	Escherichia coli
eriodictyol	-	Escherichia coli
fisetin	-	Escherichia coli
genistein	5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one	Escherichia coli
homoeriodictyol	-	Escherichia coli
isorhamnetin	3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)chromen-4-one	Escherichia coli
luteolin	-	Escherichia coli
additional information	screening of 50 flavonoids for inhibition potency against the enzyme, in silico molecular docking study, overview. Only genistein and isorhamnetin show inhibition as well as drug likeliness and bioavailability obeying the Lipinski's guidelines of five. No or poor effects by daidzein, luteolin, herbacetin, petunidin, herbacetin, malvidin, casticin, pinocembrin, kaempferol, butin, 7,3',4',5'-tetramethoxyflavanone, sternbin, galangin, dihydrooroxylin, naringenin, hispidulin, prunetin, 3,6-dihydroxyflavone, tricin, hesperetin, dihydroechioidinin 5,7-dihydroxytrimethoxyflavanone, liquiritigenin, diosmetin, isosakuranetin, dihydrowogonin, syringetin, chrysin, cajanin, naringenin trimethyl ether, pectolinarigenin, 3',4',5',5,7-pentamethoxyflavanone, glycitein, tectorigenin, 4'-hydroxy-5,6,7-trimethoxyflavanone, naringenin 5-methyl ether, 6,2',4'-trimethoxyflavanone, naringenin 7,4'-dimethyl ether, 7-hydroxyflavanone, 5,7-dihydroxyisoflavone, onysilin, and biochanin A	Escherichia coli
steppogenin	-	Escherichia coli
tamarixetin	-	Escherichia coli
thiolactomicin	thiolactomycin is an inhibitor of KAS I and inhibits bacterial cell growth through inhibition of the beta-ketoacyl-ACP synthase activity of type II fatty acids ynthases	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	E2QPI4	-	-

Synonyms

Synonyms	Comment	Organism
beta-ketoacyl acyl carrier protein synthase I	-	Escherichia coli
KAS I	-	Escherichia coli

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Release 2023.1 (January 2023)