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Literature summary for 2.3.1.41 extracted from
- Characterization of the inactivation of rat fatty acid synthase by C75: inhibition of partial reactions and protection by substrates (2005), Biochem. J., 388, 895-903.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| C75 | a synthetic inhibitor of fatty acid synthase, inhibits also the beta-ketoacyl synthase, not in simple first order rate reaction, C75 is a competitive, irreversible inhibitor of the overall reaction, the beta-ketoacyl synthase activity and the enoyl reductase activity substrates do not protect the thioesterase activity of rat liver FAS from inactivation by C75, but malonyl-CoA and acetyl-CoA protect the FAS beta-ketoacyl synthase reaction from inactivation by C75 in a competitive manner, overview | Rattus norvegicus |  |
| cerulenin | specific inhibition of the enzyme | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| native fatty acid synthase from liver in several steps including gel filtration as the last step | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + malonyl-CoA | - |
Rattus norvegicus | 3-oxobutyryl-CoA + CoA | formation of about 1% triacetic acid lactone | ? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 3-oxoacyl synthase | - |
Rattus norvegicus |
| beta-ketoacyl synthase | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 22 | - |
assay at room temperature | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
assay at | Rattus norvegicus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | inhibition kinetics | Rattus norvegicus | |
| 16 | - |
C75 | pH 7.0, 22°C, inactivation of the whole reaction of FAS | Rattus norvegicus | |
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