2.7.7.42: [glutamine synthetase] adenylyltransferase
This is an abbreviated version!
For detailed information about [glutamine synthetase] adenylyltransferase, go to the full flat file.
Word Map on EC 2.7.7.42
Reaction
Synonyms
adenosine triphosphate:glutamine synthetase adenylyltransferase, adenylyltransferase, adenylyltransferase, glutamine synthetase, ATASE, ATP:glutamine synthetase adenylyltransferase, ATP:[L-glutamate:ammonia ligase (ADP-forming)] adenylyl transferase, GlnE, glutamine synthetase adenylyl transferase, glutamine synthetase adenylyltransferase, glutamine synthetase ATase, glutamine-synthetase adenylyltransferase, GS ATase, [glutamate-ammonia-ligase] adenylyltransferase
ECTree
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Reference on EC 2.7.7.42 - [glutamine synthetase] adenylyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ebner, E.; Wolf, D.; Gancedo, C.; Elsässer, S.; Holzer, H.
ATP: glutamine synthetase adenylyltransferase from Escherichia coli B. Purification and properties
Eur. J. Biochem.
14
535-544
1970
Escherichia coli, Escherichia coli B / ATCC 11303
Wolf, D.; Ebner, E.; Hinze, H.
Inactivation, stabilization and some properties of ATP: glutamine synthetase adenylyltransferase from Escherichia coli B
Eur. J. Biochem.
25
239-244
1972
Escherichia coli, Escherichia coli B / ATCC 11303
Wolf, D.H.; Ebner, E.
Studies on the reaction mechanism of adenosine triphosphate: glutamine synthetase adenylyltransferase from Escherichia coli B. Conformational changes elicited by effectors and substrates: reactivity of sulfhydryl groups
J. Biol. Chem.
247
4208-4212
1972
Escherichia coli
Wohlhueter, R.M.; Ebner, E.; Wolf, D.H.
Studies on the reaction mechanism of adenosine triphosphate: glutamine synthetase adenylyltransferase from Escherichia coli B. Evidence for an ordered mechanism
J. Biol. Chem.
247
4213-4218
1972
Escherichia coli, Escherichia coli B / ATCC 11303
Rhee, S.G.; Park, R.; Wittenberger, M.
New enzymic assays for glutamine synthetase adenylytransferase and its regulatory protein PIIA
Anal. Biochem.
88
174-185
1978
Escherichia coli, Pseudomonas putida, Salmonella enterica subsp. enterica serovar Typhimurium
Caban, C.E.; Ginsburg, A.
Glutamine synthetase adenylyltransferase from Escherichia coli: purification and physical and chemical properties
Biochemistry
15
1569-1580
1976
Escherichia coli
Atkinson, M.R.; Ninfa, A.J.
Role of the GlnK signal transduction protein in the regulation of nitrogen assimilation in Escherichia coli
Mol. Microbiol.
29
431-447
1998
Escherichia coli
Nolden, L.; Farwick, M.; Krämer, R.; Burkovski, A.
Glutamine synthetases of Corynebacterium glutamicum: transcriptional control and regulation of activity
FEBS Lett.
201
91-98
2001
Corynebacterium glutamicum (Q79VE2), Corynebacterium glutamicum
Xu, Y.; Wen, D.; Brown, C.; Chen, C.J.; Carr, P.D.; Ollis, D.L.; Vasudevan, S.G.
Expression, purification and crystallization of the C-terminal domain of Escherichia coli adenylyltransferase
Acta Crystallogr. Sect. F
F61
663-665
2005
Escherichia coli
Mehta, R.; Pearson, J.T.; Mahajan, S.; Nath, A.; Hickey, M.J.; Sherman, D.R.; Atkins, W.M.
Adenylylation and catalytic properties of Mycobacterium tuberculosis glutamine synthetase expressed in Escherichia coli versus Mycobacteria
J. Biol. Chem.
279
22477-22482
2004
Escherichia coli
Xu, Y.; Zhang, R.; Joachimiak, A.; Carr, P.D.; Huber, T.; Vasudevan, S.G.; Ollis, D.L.
Structure of the N-terminal domain of Escherichia coli glutamine synthetase adenylyltransferase
Structure
12
861-869
2004
Escherichia coli
Jiang, P.; Pioszak, A.A.; Ninfa, A.J.
Structure-function analysis of glutamine synthetase adenylyltransferase (ATase, EC 2.7.7.49) of Escherichia coli
Biochemistry
46
4117-4132
2007
Escherichia coli, Escherichia coli YMC10
Jiang, P.; Mayo, A.E.; Ninfa, A.J.
Escherichia coli glutamine synthetase adenylyltransferase (ATase, EC 2.7.7.49): kinetic characterization of regulation by PII, PII-UMP, glutamine, and alpha-ketoglutarate
Biochemistry
46
4133-4146
2007
Escherichia coli
Jonsson, A.; Teixeira, P.F.; Nordlund, S.
The activity of adenylyltransferase in Rhodospirillum rubrum is only affected by alpha-ketoglutarate and unmodified PII proteins, but not by glutamine, in vitro
FEBS J.
274
2449-2460
2007
Rhodospirillum rubrum
Clancy, P.; Xu, Y.; van Heeswijk, W.C.; Vasudevan, S.G.; Ollis, D.L.
The domains carrying the opposing activities in adenylyltransferase are separated by a central regulatory domain
FEBS J.
274
2865-2877
2007
Escherichia coli
Jonsson, A.; Teixeira, P.F.; Nordlund, S.
A novel peroxiredoxin activity is located within the C-terminal end of Rhodospirillum rubrum adenylyltransferase
J. Bacteriol.
190
434-437
2008
Rhodospirillum rubrum
Hotter, G.S.; Mouat, P.; Collins, D.M.
Independent transcription of glutamine synthetase (glnA2) and glutamine synthetase adenylyltransferase (glnE) in Mycobacterium bovis and Mycobacterium tuberculosis
Tuberculosis
88
382-389
2008
Mycobacterium tuberculosis, Mycobacterium tuberculosis variant bovis, Mycobacterium tuberculosis H37Rv, Mycobacterium tuberculosis variant bovis AF2122/97
Jiang, P.; Ninfa, A.J.
Reconstitution of Escherichia coli glutamine synthetase adenylyltransferase from N-terminal and C-terminal fragments of the enzyme
Biochemistry
48
415-423
2009
Escherichia coli
Xu, Y.; Carr, P.D.; Vasudevan, S.G.; Ollis, D.L.
Structure of the adenylylation domain of E. coli glutamine synthetase adenylyl transferase: Evidence for gene duplication and evolution of a new active site
J. Mol. Biol.
396
773-784
2010
Escherichia coli (P30870), Escherichia coli
Van Dommelen, A.; Spaepen, S.; Vanderleyden, J.
Identification of the glutamine synthetase adenylyltransferase of Azospirillum brasilense
Res. Microbiol.
160
205-212
2009
Azospirillum brasilense (A7Y9V0), Azospirillum brasilense
Rehm, N.; Buchinger, S.; Strösser, J.; Dotzauer, A.; Walter, B.; Hans, S.; Bathe, B.; Schomburg, D.; Krämer, R.; Burkovski, A.
Impact of adenylyltransferase GlnE on nitrogen starvation response in Corynebacterium glutamicum
J. Biotechnol.
145
244-252
2010
Corynebacterium glutamicum (Q79VE2), Corynebacterium glutamicum
Jiang, P.; Peliska, J.; Ninfa, A.
The regulation of Escherichia coli glutamine synthetase revisited: Role of 2-ketoglutarate in the regulation of glutamine synthetase adenylylation state
Biochemistry
37
12802-12810
1998
Escherichia coli
Rhee, S.; Park, S.; Koo, J.
The role of adenylyltransferase and uridylyltransferase in the regulation of glutamine synthetase in Escherichia coli
Curr. Top. Cell. Regul.
27
221-232
1985
Escherichia coli
Jaggi, R.; Van Heeswijk, W.; Westerhoff, H.; Ollis, D.; Vasudevan, S.
The two opposing activities of adenylyl transferase reside in distinct homologous domains, with intramolecular signal transduction
EMBO J.
16
5562-5571
1997
Escherichia coli (P30870)
Carroll, P.; Pashley, C.; Parish, T.
Functional analysis of GlnE, an essential adenylyl transferase in Mycobacterium tuberculosis
J. Bacteriol.
190
4894-4902
2008
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Fink, D.; Falke, D.; Wohlleben, W.; Engels, A.
Nitrogen metabolism in Streptomyces coelicolor A3(2): Modification of glutamine synthetase I by an adenylyltransferase
Microbiology
145
2313-2322
1999
Streptomyces coelicolor (Q8CK02), Streptomyces coelicolor, Streptomyces coelicolor A3(2) (Q8CK02), Streptomyces coelicolor A3(2)
Van Heeswijk, W.; Hoving, S.; Molenaar, D.; Stegeman, B.; Kahn, D.; Westerhoff, H.
An alternative P(II) protein in the regulation of glutamine synthetase in Escherichia coli
Mol. Microbiol.
21
133-146
1996
Escherichia coli (P30870)
Theron, A.; Roth, R.L.; Hoppe, H.; Parkinson, C.; van der Westhuyzen, C.W.; Stoychev, S.; Wiid, I.; Pietersen, R.D.; Baker, B.; Kenyon, C.P.
Differential inhibition of adenylylated and deadenylylated forms of M. tuberculosis glutamine synthetase as a drug discovery platform
PLoS ONE
12
e0185068
2017
Mycobacterium tuberculosis (P9WN27), Mycobacterium tuberculosis H37Rv (P9WN27)
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