2.7.7.42: [glutamine synthetase] adenylyltransferase
This is an abbreviated version!
For detailed information about [glutamine synthetase] adenylyltransferase, go to the full flat file.
Word Map on EC 2.7.7.42
Reaction
Synonyms
adenosine triphosphate:glutamine synthetase adenylyltransferase, adenylyltransferase, adenylyltransferase, glutamine synthetase, ATASE, ATP:glutamine synthetase adenylyltransferase, ATP:[L-glutamate:ammonia ligase (ADP-forming)] adenylyl transferase, GlnE, glutamine synthetase adenylyl transferase, glutamine synthetase adenylyltransferase, glutamine synthetase ATase, glutamine-synthetase adenylyltransferase, GS ATase, [glutamate-ammonia-ligase] adenylyltransferase
ECTree
2.7.7.42 [glutamine synthetase] adenylyltransferaseAdvanced search results
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results (Inhibitors
Inhibitors on EC 2.7.7.42 - [glutamine synthetase] adenylyltransferase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
alpha-ketoglutarate
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in Rhodospirillum rubrum alpha-ketoglutarate inhibits the adenylylation activity of ATase
signal transduction protein PII
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inactivates the adenylyl-removing reaction
signal transduction protein PII-UMP
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reaction is inhibited by signal transduction protein PII-UMP
uridylated PII signal transduction protein
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inhibits the adenylyltransferase reaction
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uridylated signal transduction protein PII
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the adenylyltransferase reaction is activated by glutamine and by the unmodified form of the PII signal transduction protein and is inhibited by the uridylylated form of PII, PII-UMP. PII, PII-UMP, and glutamine shift the enzyme among at least six different enzyme forms, two of which are inactive, one of which exhibits adenylyl-removing activity, and three of which exhibit adenylyltranferase activity. The enzyme appears to contain two distinct sites for PII and PII-UMP. The PII, PII-UMP, and glutamine sites are in communication. The binding of PII is favored by glutamine and its level reduced by PII-UMP, whereas glutamine and PII-UMP compete for the enzyme
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2-oxoglutarate
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controls the extent of activation or inhibition of the enzyme by PII or PII-UMP. 2-Oxoglutarate acts exclusively through its binding to PII and PII-UMP, and does not alter the binding of PII or PII-UMP to the enzyme
ATP
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inhibitory above 1 mM in presence of glutamine, not related to Mg2+ concentration
