2.7.1.B20: broad specificity nucleoside kinase
This is an abbreviated version!
For detailed information about broad specificity nucleoside kinase, go to the full flat file.
Word Map on EC 2.7.1.B20
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2.7.1.B20
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deoxycytidine
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deoxyadenosine
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deoxyguanosine
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deoxyribonucleoside
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dm-dnk
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e-5-2-bromovinyl-2'-deoxyuridine
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prpp-amido
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2.7.1.74
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antiherpetic
- 2.7.1.B20
- deoxycytidine
- deoxyadenosine
- deoxyguanosine
- deoxyribonucleoside
- dm-dnk
-
e-5-2-bromovinyl-2'-deoxyuridine
-
prpp-amido
-
2.7.1.74
-
antiherpetic
Reaction
Synonyms
BTH_I1158, MJ0406, MjNK, NTP:nucleoside kinase, nucleoside kinase, PFK-B sugar kinase, Ta0880
ECTree
2.7.1.B20 broad specificity nucleoside kinaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.7.1.B20 - broad specificity nucleoside kinase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + cytidine
ADP + cytidine 5'-phosphate
catalytic efficiency with cytidine is 45% relative to guanosine
-
-
?
ATP + mizoribine
ADP + mizoribine 5'-phosphate
i.e. 5-hydroxy-1-beta-D-ribofuranosyl-1H-imidazole-4-carboxamide. Phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
-
-
?
CTP + inosine
CDP + inosine 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
-
-
?
GTP + cytidine
GDP + CMP
relative phosphoryl donor specificity: ATP (100%), ITP (41%), GTP (40%), UTP (8%), CTP (6%)
-
-
?
GTP + guanosine
GDP + GMP
relative phosphoryl donor specificity: ATP (100%), ITP (41%), GTP (40%), UTP (8%), CTP (6%)
-
-
?
GTP + guanosine
GDP + guanosine 5'-phosphate
phosphoryl donor specificity in order of decreasing Vmax: GTP > ATP > ITP. The catalytic efficiency of GTP is 39% compared to that of ATP
-
-
?
GTP + inosine
GDP + IMP
relative phosphoryl donor specificity: ATP (100%), ITP (41%), GTP (40%), UTP (8%), CTP (6%)
-
-
?
GTP + inosine
GDP + inosine 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
-
-
?
ITP + cytidine
IDP + CMP
relative phosphoryl donor specificity: ATP (100%), ITP (41%), GTP (40%), UTP (8%), CTP (6%)
-
-
?
ITP + guanosine
IDP + GMP
relative phosphoryl donor specificity: ATP (100%), ITP (41%), GTP (40%), UTP (8%), CTP (6%)
-
-
?
ITP + guanosine
IDP + guanosine 5'-phosphate
phosphoryl donor specificity in order of decreasing Vmax: GTP > ATP > ITP
-
-
?
ITP + inosine
IDP + IMP
relative phosphoryl donor specificity: ATP (100%), ITP (41%), GTP (40%), UTP (8%), CTP (6%)
-
-
?
ITP + inosine
IDP + inosine 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
-
-
?
TTP + inosine
TDP + inosine 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
-
-
?
UTP + inosine
UDP + inosine 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
-
-
?
ATP + 2'-deoxyadenosine
ADP + 2'-deoxyadenosine 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
-
-
?
ATP + 2'-deoxyadenosine
ADP + 2'-deoxyadenosine 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
-
-
?
ATP + adenosine
ADP + adenosine 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
-
-
?
ATP + adenosine
ADP + adenosine 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
-
-
?
ATP + adenosine
ADP + adenosine 5'-phosphate
catalytic efficiency with cytidine is 22% relative to guanosine
-
-
?
ATP + cytidine
ADP + CMP
at 70°C the Vmax/Km-value for cytidine is 93% of the Vmax/Km-value for inosine. At 50°C the Vmax/Km-value for cytidine is 59% of the Vmax/Km-value for inosine. Neither ADP, acetyl phosphate, nor diphosphate can replace ATP
-
-
?
ATP + cytidine
ADP + CMP
at 70°C the Vmax/Km-value for cytidine is 93% of the Vmax/Km-value for inosine. At 50°C the Vmax/Km-value for cytidine is 59% of the Vmax/Km-value for inosine. Neither ADP, acetyl phosphate, nor diphosphate can replace ATP
-
-
?
ATP + guanosine
ADP + GMP
at 70°C the Vmax/Km-value for guanosine is 52% of the Vmax/Km-value for inosine. At 50°C the Vmax/Km-value for guanosine is 52% of the Vmax/Km-value for inosine. Neither ADP, acetyl phosphate, nor diphosphate can replace ATP
-
-
?
ATP + guanosine
ADP + GMP
at 70°C the Vmax/Km-value for guanosine is 52% of the Vmax/Km-value for inosine. At 50°C the Vmax/Km-value for guanosine is 52% of the Vmax/Km-value for inosine. Neither ADP, acetyl phosphate, nor diphosphate can replace ATP
-
-
?
ATP + guanosine
ADP + guanosine 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
-
-
?
ATP + guanosine
ADP + guanosine 5'-phosphate
phosphoryl donor specificity in order of decreasing Vmax: GTP > ATP > ITP. The catalytic efficiency of GTP is 39% compared to that of ATP
-
-
?
ATP + inosine
ADP + IMP
relative phosphoryl donor specificity: ATP (100%), ITP (41%), GTP (40%), UTP (8%), CTP (6%)
-
-
?
ATP + inosine
ADP + IMP
relative phosphoryl donor specificity: ATP (100%), ITP (41%), GTP (40%), UTP (8%), CTP (6%)
-
-
?
ATP + inosine
ADP + inosine 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
-
-
?
ATP + inosine
ADP + inosine 5'-phosphate
catalytic efficiency with inosine is 62% relative to guanosine
-
-
?
ATP + ribavirin
ADP + ribavirin 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
-
-
?
ATP + ribavirin
ADP + ribavirin 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
-
-
?
ATP + uridine
ADP + uridine 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
-
-
?
ATP + uridine
ADP + uridine 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
-
-
?
additional information
?
-
in the presence of D-ribose, L-ribose, fructose, glucose, 2-deoxy-glucose, xanthosine, galactose, xylose, N-acetyl glucosamine, fructose-6-phosphate, mannose-6-phosphate and ribose-5-phosphate, the activity is below the detection limit. No activity with cytidine or thamidine
-
-
?
additional information
?
-
-
in the presence of D-ribose, L-ribose, fructose, glucose, 2-deoxy-glucose, xanthosine, galactose, xylose, N-acetyl glucosamine, fructose-6-phosphate, mannose-6-phosphate and ribose-5-phosphate, the activity is below the detection limit. No activity with cytidine or thamidine
-
-
?
additional information
?
-
in the presence of D-ribose, L-ribose, fructose, glucose, 2-deoxy-glucose, xanthosine, galactose, xylose, N-acetyl glucosamine, fructose-6-phosphate, mannose-6-phosphate and ribose-5-phosphate, the activity is below the detection limit. No activity with cytidine or thamidine
-
-
?
additional information
?
-
the enzyme plays a role in nucleotide metabolism
-
-
?
additional information
?
-
-
the enzyme plays a role in nucleotide metabolism
-
-
?
additional information
?
-
adenosine, xanthosine, 2'-deoxyadenosine, uridine, and thymidine are used at low rates, the enzyme catalyses the ATP-dependent phosphorylation of D-fructose 6-phosphate at an extremely low rate
-
-
?
additional information
?
-
-
adenosine, xanthosine, 2'-deoxyadenosine, uridine, and thymidine are used at low rates, the enzyme catalyses the ATP-dependent phosphorylation of D-fructose 6-phosphate at an extremely low rate
-
-
?
additional information
?
-
the enzyme plays a role in nucleotide metabolism
-
-
?
additional information
?
-
adenosine, xanthosine, 2'-deoxyadenosine, uridine, and thymidine are used at low rates, the enzyme catalyses the ATP-dependent phosphorylation of D-fructose 6-phosphate at an extremely low rate
-
-
?
additional information
?
-
negligible enzymatic activity with thymidine, uridine, and 2-deoxyadenosine. Negligible enzymatic activity is observed with UTP and TTP as phosphate donors
-
-
?
additional information
?
-
-
negligible enzymatic activity with thymidine, uridine, and 2-deoxyadenosine. Negligible enzymatic activity is observed with UTP and TTP as phosphate donors
-
-
?
