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2.7.1.52: fucokinase

This is an abbreviated version!
For detailed information about fucokinase, go to the full flat file.

Word Map on EC 2.7.1.52

Reaction

ATP
+
L-fucose
=
ADP
+
beta-L-fucose 1-phosphate

Synonyms

ATP:6-deoxy-beta-L-galactose 1-phosphotransferase, ATP:6-deoxy-L-galactose 1-phospho transferase, Fkgp, FKP, fucokinase, fucokinase/L-fucose-1-P-guanylyltransferase, fucokinase:GDP-fucose pyrophosphorylase, fucose kinase, Fuk, kinase, fuco- (phosphorylating), L-fucokinase, L-fucokinase/guanosine 5'-diphosphate-L-fucose pyrophosphorylase, L-fucokinase/guanosine-5'-diphosphate-Fuc pyrophosphorylase, L-fucokinase:GDP-fucose pyrophosphorylase, L-fucose kinase, L-fucose kinase/GDP-L-fucose pyrophosphorylase, More

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.52 fucokinase

Engineering

Engineering on EC 2.7.1.52 - fucokinase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
G133A
-
mutation abolishes GDP-L-fucose diphosphorylase activity, hardly affects fucokinase activity
G830A
-
mutation reduces fucokinase activity by more than 90%, while preserving the GDP-L-fucose diphosphorylase activity
A723R
the fucokinase activity of the mutant is totally abolished
D594A
the mutant retains hardly any fucokinase activity
D601A
the mutant retains hardly any fucokinase activity
D762A
the mutant retains hardly any fucokinase activity
G597A
the mutant retains hardly any fucokinase activity
G598A
the mutant retains hardly any fucokinase activity
G713A
the fucokinase activity of the mutant is totally abolished
G715A
the fucokinase activity of the mutant is totally abolished
G717A
the fucokinase activity of the mutant is totally abolished
G757A
the mutant has greatly reduced fucokinase activity compared to the wild type enzyme
G758A
the mutant retains hardly any fucokinase activity
G759A
the mutant retains hardly any fucokinase activity
G899A
the mutant retains hardly any fucokinase activity
G901A
the mutant retains hardly any fucokinase activity
G902A
the mutant has greatly reduced fucokinase activity compared to the wild type enzyme
Q761A
the mutant retains hardly any fucokinase activity
R592A
the mutant retains hardly any fucokinase activity
S714A
the fucokinase activity of the mutant is totally abolished
S719A
the fucokinase activity of the mutant is totally abolished
S720A
the fucokinase activity of the mutant is totally abolished
T602A
the mutant has greatly reduced fucokinase activity compared to the wild type enzyme
D762A
-
the mutant retains hardly any fucokinase activity
-
G598A
-
the mutant retains hardly any fucokinase activity
-
G713A
-
the fucokinase activity of the mutant is totally abolished
-
R592A
-
the mutant retains hardly any fucokinase activity
-
S714A
-
the fucokinase activity of the mutant is totally abolished
-
additional information