Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

2.7.1.177: L-threonine kinase

This is an abbreviated version!
For detailed information about L-threonine kinase, go to the full flat file.

Word Map on EC 2.7.1.177

Reaction

ATP
+
L-threonine
=
ADP
 +
O-phospho-L-threonine

Synonyms

bluE, L-Thr kinase, L-Thr kinase/L-Thr-P decarboxylase, L-Thr kinase/L-Thr-phosphate decarboxylase, MmCobD, More, PduX, RsBluE, RSP_0788

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.177 L-threonine kinase

Metals Ions

Metals Ions on EC 2.7.1.177 - L-threonine kinase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
activates at low concentration, but inhibits 75% at 100 mM
Co2+
very low acctivation
Fe2+
the wild-type MmCobD that is normoxically or anoxically purified and then reconstituted, or anoxically purified without reconstitution contains an average of 25 Fe atoms per monomer, with rather poor standard deviations. The C-terminus of MmCobD contains one or more [4Fe-4S] 2+ cluster(s). Although these [4Fe-4S]2+ cluster(s) are not required for activity, perturbations in the C-terminal domain result in the loss of Fe2+ and alterations in the enzyme activities associated with the N-terminus. The C-terminus is not required for the kinase or decarboxylase activities, the [4Fe-4S]2+ cluster-containing C-terminus may have a regulatory role, perhaps by gating the active site or facilitating the decarboxylation and or kinase reactions. Fe2+ is not detected in the N-terminus only (MmCobD1-385) protein sample
Mn2+
required, activates
additional information