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metabolism
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the enzyme regulates plasma-membrane phosphatidylinositol 3,4,5-trisphosphate turnover and insulin signalling. The enzyme is required to limit phosphatidylinositol 3,4,5-trisphosphate levels during insulin receptor activation
evolution
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PI5P4Kalpha is present in all vertebrates, and a few organisms are missing either beta or gamma. Several key structural differences between the three mammalian PI5P4Ks largely account for their different activities, e.g. a glycine-rich loop supposed to be involved with substrate interaction
evolution
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two subfamilies of phosphatidylinositol 5-phosphate 4-kinase kinases produce 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate from independent pools of substrates. In addition, type I and II subfamilies of PIPK can localize in different subcellular compartments and are involved in the synthesis of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate in distinct sites within cell
evolution
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two subfamilies of phosphatidylinositol 5-phosphate 4-kinases produce 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate from independent pools of substrates. In addition, type I and II subfamilies of PIPK can localize in different subcellular compartments and are involved in the synthesis of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate in distinct sites within cell
evolution
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two subfamilies of phosphatidylinositol 5-phosphate 4-kinases produce 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate from independent pools of substrates. In addition, type I and II subfamilies of PIPK can localize in different subcellular compartments and are involved in the synthesis of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate in distinct sites within cell
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malfunction
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phosphatidylinositol-5-phosphate 4-kinase type II beta knockdown inhibits E-cadherin upregulation induced by the vitamin D3 metabolite 1alpha,25(OH)2D3, while phosphatidylinositol-5-phosphate 4-kinase type II alpha does not
malfunction
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enzyme knockdown leads to severe morphological abnormalities, including midbody winding defects at 48 h post-fertilization
malfunction
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isoform PI4Kgamma5 deficiency results in the serrated leaves and accelerated cell division at leaf margin due to the increased auxin level
malfunction
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loss-of-function mutants in PIP4K show reduced body weight and prolonged larval development
malfunction
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enzyme depletion enhances the spindle pole accumulation of mitotic centromere-associated kinesin, a microtubule-depolymerizing kinesin, and results in a less stable spindle pole-associated microtubule
malfunction
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enzyme-deficient animals show enhanced insulin signaling-dependent phenotypes and are resistant to the metabolic consequences of a high-sugar diet
malfunction
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flies lacking the enzyme show mislocalization of rhodopsin 1 on expanded endomembranes within the cell body. Enzyme loss is associated with increased clathrin-mediated endocytosis and an enlarged Rab5-positive compartment in cultured Drosophila cells
malfunction
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long-Term loss of isoform PI5P4Kalpha by gene disruption results in compromised Akt phosphorylation
malfunction
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mice lacking both enzyme isoforms in the liver have a defect in the ability to catabolize lipid droplets following a period of fasting. Enzyme loss of both isoforms results in lipid droplets accumulation and autophagy defects in MEF cells. Enzyme loss modifies expression of lysosomal and mTORC1 genes and alters metabolism as well as increases transcription factor EB nuclear translocation and activity
physiological function
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greater type II alpha PIP kinase activity in the light-adapted rod outer segment membrane results from light-driven translocation of PIPKIIalpha from the rod inner segment to rod outer segment, and subsequent binding to the rod outer segment membrane, thus improving access of the kinase to its lipid substrates. Light-induced tyrosine phosphorylation of rod outer segment membrane proteins regulate the translocation, membrane binding and activation of type II alpha phosphatidylinositol-5-phosphate 4-kinase
physiological function
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greater type II alpha PIP kinase activity in the light-adapted rod outer segment membrane results from light-driven translocation of PIPKIIalpha from the rod inner segment to rod outer segment, and subsequent binding to the rod outer segment membrane, thus improving access of the kinase to its lipid substrates. Light-induced tyrosine phosphorylation of rod outer segment membrane proteins regulate the translocation, membrane binding and activation of type II alpha phosphatidylinositol-5-phosphate 4-kinase
physiological function
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isozyme PIP4Kalpha affects the ubiquitination of isozyme PIP4Kbeta by the SPOP-CUL3 complex. Isozyme PIP4Kbeta can modulate the nuclear localization of isozyme PIP4Kalpha, and isozyme PIP4Kalpha has a role in regulating isozyme PIP4Kbeta functions
physiological function
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isozyme PIP4Kalpha affects the ubiquitination of isozyme PIP4Kbeta by the SPOP-CUL3 complex. Isozyme PIP4Kbeta can modulate the nuclear localization of isozyme PIP4Kalpha, and isozyme PIP4Kalpha has a role in regulating isozyme PIP4Kbeta functions
physiological function
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the enzyme is required for vitamin D receptor-mediated E-cadherin induction in SW480-ADH cells expressing the vitamin D receptor. The enzyme is also involved in the suppression of the cell motility induced by 1alpha,25-dihydroxyvitamin D3, PIPKIIbeta inhibits the migratory activity of SW480-ADH cells. PIPKIIbeta-mediated phosphatidylinositol-4,5-bisphosphate signaling is important for E-cadherin upregulation and inhibition of cellular motility induced by vitamin D receptor activation. PIPKIIbeta but not PIPKIIalpha promotes E-cadherin upregulation in the presence of 1alpha,25(OH)2D3, overview
physiological function
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isoform PI4Kgamma5 interacts with transcription factor ANAC078 to negatively regulate auxin synthesis and hence influences cell proliferation and leaf development
physiological function
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the enzyme is part of piperine-mediated anti-inflammatory signaling mechanisms
physiological function
the enzyme isoform PIP5K2B is linked to the pathogenesis of obesity, insulin resistance and diabetes
physiological function
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the enzyme plays a role in CD3 receptor signal transduction and is is a key component in early T cell activation signaling cascades
physiological function
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the enzyme regulates TOR signaling and cell growth during Drosophila development
physiological function
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human enzyme isoforms are able to rescue salivary gland cell size defects in the Drosophila enzyme-deficient mutant
physiological function
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the enzyme is necessary for maintenance of normal plasma membrane phosphatidylinositol (3,4,5)-trisphosphate levels in DT-40 cells. The enzyme is an acute negative regulator of mammalian target of rapamycin complex 2
physiological function
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the enzyme is required for the assembly of bipolar spindles. The enzyme and phosphatidylinositol 4,5-bisphosphate may negatively regulate the microtubule depolymerization activity of mitotic centromere-associated kinesin by reducing polo-like kinase 1-mediated phosphorylation of mitotic centromere-associated kinesin
physiological function
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the enzyme isoforms play potential roles in synaptic transmission
physiological function
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the enzyme plays a critical role in autophagy in times of energy stress
physiological function
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the enzyme regulates clathrin-mediated endocytosis of rhodopsin 1 and supports rhodopsin 1 trafficking during pupal metamorphosis
physiological function
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greater type II alpha PIP kinase activity in the light-adapted rod outer segment membrane results from light-driven translocation of PIPKIIalpha from the rod inner segment to rod outer segment, and subsequent binding to the rod outer segment membrane, thus improving access of the kinase to its lipid substrates. Light-induced tyrosine phosphorylation of rod outer segment membrane proteins regulate the translocation, membrane binding and activation of type II alpha phosphatidylinositol-5-phosphate 4-kinase
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