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2.7.1.149: 1-phosphatidylinositol-5-phosphate 4-kinase

This is an abbreviated version!
For detailed information about 1-phosphatidylinositol-5-phosphate 4-kinase, go to the full flat file.

Word Map on EC 2.7.1.149

Reaction

ATP
+
1-phosphatidyl-1D-myo-inositol 5-phosphate
=
ADP
 +
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Synonyms

1-phosphatidylinositol-4-phosphate 5-kinase, 1-phosphatidylinositol-4-phosphate kinase, 1-phosphatidylinositol-5-phosphate 4-kinase, Diphosphoinositide kinase, MSS4p, pan-phosphatidylinositol 5-phosphate 4-kinase, pan-PI5P4K, phosphatidylinositol 4-kinase, phosphatidylinositol 4-phosphate 5-kinase gamma, phosphatidylinositol 5 phosphate 4-kinase, phosphatidylinositol 5-phosphate 4-kinase, phosphatidylinositol 5-phosphate 4-kinase gamma, phosphatidylinositol 5-phosphate 4-kinase-alpha, phosphatidylinositol 5-phosphate, 4-kinase alpha, phosphatidylinositol 5-phosphate, 4-kinase beta, phosphatidylinositol phosphate kinase II gamma, phosphatidylinositol-5-phosphate 4-kinase, phosphatidylinositol-5-phosphate 4-kinase alpha, phosphatidylinositol-5-phosphate 4-kinase gamma, phosphatidylinositol-5-phosphate 4-kinase type II, phosphatidylinositol-5-phosphate 4-kinase type II beta, phosphatidylinositol-5-phosphate 4-kinase type-2 gamma, phosphatidylinositol-5-phosphate 4-kinase, type II, beta, PI-5-phosphate 4-kinase type II, PI4Kgamma5, PI4P-5 kinase, PI5P 4-kinase, PI5P4K, PI5P4Kalpha, PI5P4Kbeta, PI5P4Kgamma, PIP(4)K, PIP4K, PIP4K II, Pip4k2a, Pip4k2b, PIP4K2C, PIP4Kalpha, PIP4Kbeta, PIP4Kgamma, PIP4KIIalpha, PIP4KIIgamma, PIP5K2B, PIP5Kgamma, PIP5KII-alpha, PIP5KIII, PIPKII, PIPKIIalpha, PIPKIIbeta, PIPkinIIbeta, PtdIns(4)P-5-kinase B isoform, PtdIns(4)P-5-kinase C isoform, PtdIns5P 4-kinase, PtdIns5P-4-kinase, PtdIns5P4-kinase, type II alpha phosphatidylinositol-5-phosphate 4-kinase, type II kinase, type II phosphatidylinositol 4-kinase, type II phosphatidylinositol 4-kinase beta, type II PI-5-P 4-kinase, type II PIP kinase, type II PtdIns 4-kinase, type II PtdIns 4-kinase beta, type IIbeta phosphatidylinositol 5-phosphate 4-kinase, type IIbeta PIPkin

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.149 1-phosphatidylinositol-5-phosphate 4-kinase

Reference

topprint

Reference on EC 2.7.1.149 - 1-phosphatidylinositol-5-phosphate 4-kinase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rameh, L.E.; Tolias, K.F.; Duckworth, B.C.; Cantley, L.C.
A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate
Nature
390
192-196
1997
Homo sapiens
Manually annotated by BRENDA team
Itoh, T.; Ijuin, T.; Takenawa, T.
A novel phosphatidylinositol-5-phosphate 4-kinase (phosphatidylinositol-phosphate kinase IIgamma) is phosphorylated in the endoplasmic reticulum in response to mitogenic signals
J. Biol. Chem.
273
20292-20299
1998
Rattus norvegicus
Manually annotated by BRENDA team
Carricaburu, V.; Lamia, K.A.; Lo, E.; Favereaux, L.; Payrastre, B.; Cantley, L.C.; Rameh, L.E.
The phosphatidylinositol (PI)-5-phosphate 4-kinase type II enzyme controls insulin signaling by regulating PI-3,4,5-trisphosphate degradation
Proc. Natl. Acad. Sci. USA
100
9867-9872
2003
Homo sapiens
Manually annotated by BRENDA team
Hinchliffe, K.A.; Irvine, R.F.
Regulation of type II PIP kinase by PKD phosphorylation
Cell. Signal.
18
1906-1913
2006
Sus scrofa
Manually annotated by BRENDA team
Clarke, J.H.; Emson, P.C.; Irvine, R.F.
Localization of Phosphatidylinositol phosphate Kinase II gamma in kidney to a membrane trafficking compartment within specialized cells of the nephron
Am. J. Physiol. Renal Physiol.
295
F1422-1430
2008
Homo sapiens (Q8TBX8), Mus musculus (Q91XU3)
Manually annotated by BRENDA team
Richardson, J.P.; Wang, M.; Clarke, J.H.; Patel, K.J.; Irvine, R.F.
Genomic tagging of endogenous type IIbeta phosphatidylinositol 5-phosphate 4-kinase in DT40 cells reveals a nuclear localization
Cell. Signal.
19
1309-1314
2007
Gallus gallus, Homo sapiens (P78356)
Manually annotated by BRENDA team
Clarke, J.; Irvine, R.
The activity, evolution and association of phosphatidylinositol 5-phosphate 4-kinases
Adv. Biol. Regul.
52
40-45
2012
Mammalia
Manually annotated by BRENDA team
Kouchi, Z.; Fujiwara, Y.; Yamaguchi, H.; Nakamura, Y.; Fukami, K.
Phosphatidylinositol 5-phosphate 4-kinase type II beta is required for vitamin D receptor-dependent E-cadherin expression in SW480 cells
Biochem. Biophys. Res. Commun.
408
523-529
2011
Homo sapiens
Manually annotated by BRENDA team
Bultsma, Y.; Keune, W.J.; Divecha, N.
PIP4Kbeta interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kalpha
Biochem. J.
430
223-235
2010
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Huang, Z.; Anderson, R.E.; Cao, W.; Wiechmann, A.F.; Rajala, R.V.
Light-induced tyrosine phosphorylation of rod outer segment membrane proteins regulate the translocation, membrane binding and activation of type II alpha phosphatidylinositol-5-phosphate 4-kinase
Neurochem. Res.
36
627-635
2011
Mus musculus, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Manually annotated by BRENDA team
Davis, M.I.; Sasaki, A.T.; Shen, M.; Emerling, B.M.; Thorne, N.; Michael, S.; Pragani, R.; Boxer, M.; Sumita, K.; Takeuchi, K.; Auld, D.S.; Li, Z.; Cantley, L.C.; Simeonov, A.
A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation
PLoS ONE
8
e54127
2013
Homo sapiens
Manually annotated by BRENDA team
Bulley, S.J.; Clarke, J.H.; Droubi, A.; Giudici, M.L.; Irvine, R.F.
Exploring phosphatidylinositol 5-phosphate 4-kinase function
Adv. Biol. Regul.
57
193-202
2015
Homo sapiens
Manually annotated by BRENDA team
Voss, M.D.; Czechtizky, W.; Li, Z.; Rudolph, C.; Petry, S.; Brummerhop, H.; Langer, T.; Schiffer, A.; Schaefer, H.L.
Discovery and pharmacological characterization of a novel small molecule inhibitor of phosphatidylinositol-5-phosphate 4-kinase, type II, beta
Biochem. Biophys. Res. Commun.
449
327-331
2014
Homo sapiens (P78356)
Manually annotated by BRENDA team
Clarke, J.H.; Irvine, R.F.
Evolutionarily conserved structural changes in phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) isoforms are responsible for differences in enzyme activity and localization
Biochem. J.
454
49-57
2013
Homo sapiens (P48426), Homo sapiens (P78356), Homo sapiens (Q8TBX8), Homo sapiens
Manually annotated by BRENDA team
Clarke, J.H.; Giudici, M.L.; Burke, J.E.; Williams, R.L.; Maloney, D.J.; Marugan, J.; Irvine, R.F.
The function of phosphatidylinositol 5-phosphate 4-kinase gamma (PI5P4Kgamma) explored using a specific inhibitor that targets the PI5P-binding site
Biochem. J.
466
359-367
2015
Mus musculus
Manually annotated by BRENDA team
Sinha, R.K.; Bojjireddy, N.; Kulkarni, D.; Ratheesh, A.; Chiplunkar, S.V.; Gude, R.; Subrahmanyam, G.
Type II phosphatidylinositol 4-kinase beta is an integral signaling component of early T cell activation mechanisms
Biochimie
95
1560-1566
2013
Homo sapiens
Manually annotated by BRENDA team
Boura, E.; Nencka, R.
Phosphatidylinositol 4-kinases: Function, structure, and inhibition
Exp. Cell Res.
337
136-145
2015
Homo sapiens
Manually annotated by BRENDA team
Elouarrat, D.; van der Velden, Y.U.; Jones, D.R.; Moolenaar, W.H.; Divecha, N.; Haramis, A.P.
Role of phosphatidylinositol 5-phosphate 4-kinase ? in zebrafish development
Int. J. Biochem. Cell Biol.
45
1293-1301
2013
Danio rerio
Manually annotated by BRENDA team
Xu, J.X.; Si, M.; Zhang, H.R.; Chen, X.J.; Zhang, X.D.; Wang, C.; Du, X.N.; Zhang, H.L.
Phosphoinositide kinases play key roles in norepinephrine- and angiotensin II-induced increase in phosphatidylinositol 4,5-bisphosphate and modulation of cardiac function
J. Biol. Chem.
289
6941-6948
2014
Rattus norvegicus
Manually annotated by BRENDA team
Bojjireddy, N.; Sinha, R.K.; Subrahmanyam, G.
Type II phosphatidylinositol 4-kinases interact with FcepsilonRIgamma subunit in RBL-2H3 cells
Mol. Cell. Biochem.
390
197-203
2014
Homo sapiens
Manually annotated by BRENDA team
Tang, Y.; Zhao, C.Y.; Tan, S.T.; Xue, H.W.
Arabidopsis type II phosphatidylinositol 4-kinase PI4Kgamma5 regulates auxin biosynthesis and leaf margin development through interacting with membrane-bound transcription factor ANAC078
PLoS Genet.
12
e1006252
2016
Arabidopsis thaliana
Manually annotated by BRENDA team
Gupta, A.; Toscano, S.; Trivedi, D.; Jones, D.R.; Mathre, S.; Clarke, J.H.; Divecha, N.; Raghu, P.
Phosphatidylinositol 5-phosphate 4-kinase (PIP4K) regulates TOR signaling and cell growth during Drosophila development
Proc. Natl. Acad. Sci. USA
110
5963-5968
2013
Drosophila melanogaster
Manually annotated by BRENDA team
Manz, T.D.; Sivakumaren, S.C.; Yasgar, A.; Hall, M.D.; Davis, M.I.; Seo, H.S.; Card, J.D.; Ficarro, S.B.; Shim, H.; Marto, J.A.; Dhe-Paganon, S.; Sasaki, A.T.; Boxer, M.B.; Simeonov, A.; Cantley, L.C.; Shen, M.; Zhang, T.; Ferguson, F.M.; Gray, N.S.
Structure-activity relationship study of covalent pan-phosphatidylinositol 5-phosphate 4-kinase inhibitors
ACS Med. Chem. Lett.
11
346-352
2020
Homo sapiens
Manually annotated by BRENDA team
Giudici, M.; Clarke, J.; Irvine, R.
Phosphatidylinositol 5-phosphate 4-kinase gamma (PI5P4Kgamma), a lipid signalling enigma
Adv. Biol. Regul.
61
47-50
2016
Homo sapiens
Manually annotated by BRENDA team
Droubi, A.; Bulley, S.; Clarke, J.; Irvine, R.
Nuclear localizations of phosphatidylinositol 5-phosphate 4-kinases alpha and beta are dynamic and independently regulated during starvation-induced stress
Biochem. J.
473
2155-2163
2016
Gallus gallus
Manually annotated by BRENDA team
Mathre, S.; Reddy, K.B.; Ramya, V.; Krishnan, H.; Ghosh, A.; Raghu, P.
Functional analysis of the biochemical activity of mammalian phosphatidylinositol 5 phosphate 4-kinase enzymes
Biosci. Rep.
39
BSR20182210
2019
Homo sapiens
Manually annotated by BRENDA team
Lin, T.C.; Kuo, H.H.; Wu, Y.C.; Pan, T.S.; Yih, L.H.
Phosphatidylinositol-5-phosphate 4-kinase gamma accumulates at the spindle pole and prevents microtubule depolymerization
Cell Div.
14
9-9
2019
Homo sapiens
Manually annotated by BRENDA team
Sharma, S.; Mathre, S.; Ramya, V.; Shinde, D.; Raghu, P.
Phosphatidylinositol 5 phosphate 4-kinase regulates plasma-membrane PIP3 turnover and insulin signaling
Cell Rep.
27
1979-1990
2019
Drosophila melanogaster
Manually annotated by BRENDA team
Kamalesh, K.; Trivedi, D.; Toscano, S.; Sharma, S.; Kolay, S.; Raghu, P.
Phosphatidylinositol 5-phosphate 4-kinase regulates early endosomal dynamics during clathrin-mediated endocytosis
J. Cell Sci.
130
2119-2133
2017
Drosophila melanogaster
Manually annotated by BRENDA team
Noch, E.K.; Yim, I.; Milner, T.A.; Cantley, L.C.
Distribution and localization of phosphatidylinositol 5-phosphate, 4-kinase alpha and beta in the brain
J. Comp. Neurol.
529
434-449
2020
Mus musculus
Manually annotated by BRENDA team
Manz, T.D.; Sivakumaren, S.C.; Ferguson, F.M.; Zhang, T.; Yasgar, A.; Seo, H.S.; Ficarro, S.B.; Card, J.D.; Shim, H.; Miduturu, C.V.; Simeonov, A.; Shen, M.; Marto, J.A.; Dhe-Paganon, S.; Hall, M.D.; Cantley, L.C.; Gray, N.S.
Discovery and structure-activity relationship study of (Z)-5-methylenethiazolidin-4-one derivatives as potent and selective pan-phosphatidylinositol 5-phosphate 4-kinase inhibitors
J. Med. Chem.
63
4880-4895
2020
Homo sapiens
Manually annotated by BRENDA team
Davis, M.; Sasaki, A.; Simeonov, A.
Method for assaying the lipid kinase phosphatidylinositol-5-phosphate 4-kinase alpha in quantitative high-throughput screening (qHTS) bioluminescent format
Methods Mol. Biol.
1376
1-9
2016
Homo sapiens (P48426)
Manually annotated by BRENDA team
Lundquist, M.; Goncalves, M.; Loughran, R.; Possik, E.; Vijayaraghavan, T.; Yang, A.; Pauli, C.; Ravi, A.; Verma, A.; Yang, Z.; Johnson, J.; Wong, J.; Ma, Y.; Hwang, K.; Weinkove, D.; Divecha, N.; Asara, J.; Elemento, O.; Rubin, M.; Kimmelman, A.; Pause, A.
Phosphatidylinositol-5-phosphate 4-kinases regulate cellular lipid metabolism by facilitating autophagy
Mol. Cell.
70
531-544
2018
Mus musculus
Manually annotated by BRENDA team
Bulley, S.J.; Droubi, A.; Clarke, J.H.; Anderson, K.E.; Stephens, L.R.; Hawkins, P.T.; Irvine, R.F.
In B cells, phosphatidylinositol 5-phosphate 4-kinase-alpha synthesizes PI(4,5)P2 to impact mTORC2 and Akt signaling
Proc. Natl. Acad. Sci. USA
113
10571-10576
2016
Gallus gallus
Manually annotated by BRENDA team