2.7.1.149: 1-phosphatidylinositol-5-phosphate 4-kinase

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For detailed information about 1-phosphatidylinositol-5-phosphate 4-kinase, go to the full flat file.

Word Map on EC 2.7.1.149

2.7.1.149

4,5-bisphosphate

phospholipase

ptdins4p

pi4kiii

ptdins4,5p2

wortmannin

pip2

trans-golgi

polyphosphoinositides

dfg-out

phosphatidylinositol-4,5-bisphosphate

pip5ks

phenylarsine

3-kinases

positive-sense

oxysterol-binding

enteroviruses

ns5a

picornaviruses

medicine

Reaction

1-phosphatidyl-1D-myo-inositol 5-phosphate

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Synonyms

1-phosphatidylinositol-4-phosphate 5-kinase, 1-phosphatidylinositol-4-phosphate kinase, 1-phosphatidylinositol-5-phosphate 4-kinase, Diphosphoinositide kinase, MSS4p, pan-phosphatidylinositol 5-phosphate 4-kinase, pan-PI5P4K, phosphatidylinositol 4-kinase, phosphatidylinositol 4-phosphate 5-kinase gamma, phosphatidylinositol 5 phosphate 4-kinase, phosphatidylinositol 5-phosphate 4-kinase, phosphatidylinositol 5-phosphate 4-kinase gamma, phosphatidylinositol 5-phosphate 4-kinase-alpha, phosphatidylinositol 5-phosphate, 4-kinase alpha, phosphatidylinositol 5-phosphate, 4-kinase beta, phosphatidylinositol phosphate kinase II gamma, phosphatidylinositol-5-phosphate 4-kinase, phosphatidylinositol-5-phosphate 4-kinase alpha, phosphatidylinositol-5-phosphate 4-kinase gamma, phosphatidylinositol-5-phosphate 4-kinase type II, phosphatidylinositol-5-phosphate 4-kinase type II beta, phosphatidylinositol-5-phosphate 4-kinase type-2 gamma, phosphatidylinositol-5-phosphate 4-kinase, type II, beta, PI-5-phosphate 4-kinase type II, PI4Kgamma5, PI4P-5 kinase, PI5P 4-kinase, PI5P4K, PI5P4Kalpha, PI5P4Kbeta, PI5P4Kgamma, PIP(4)K, PIP4K, PIP4K II, Pip4k2a, Pip4k2b, PIP4K2C, PIP4Kalpha, PIP4Kbeta, PIP4Kgamma, PIP4KIIalpha, PIP4KIIgamma, PIP5K2B, PIP5Kgamma, PIP5KII-alpha, PIP5KIII, PIPKII, PIPKIIalpha, PIPKIIbeta, PIPkinIIbeta, PtdIns(4)P-5-kinase B isoform, PtdIns(4)P-5-kinase C isoform, PtdIns5P 4-kinase, PtdIns5P-4-kinase, PtdIns5P4-kinase, type II alpha phosphatidylinositol-5-phosphate 4-kinase, type II kinase, type II phosphatidylinositol 4-kinase, type II phosphatidylinositol 4-kinase beta, type II PI-5-P 4-kinase, type II PIP kinase, type II PtdIns 4-kinase, type II PtdIns 4-kinase beta, type IIbeta phosphatidylinositol 5-phosphate 4-kinase, type IIbeta PIPkin

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

2.7.1.149 1-phosphatidylinositol-5-phosphate 4-kinase

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Results	in table
53	AA Sequence
1	Application
2	CAS Registry Number
18	Cloned(Commentary)
11	Cofactor
1	Crystallization (Commentary)
313	Disease/ Diagnostics
2	Expression
31	General Information
86	IC50 Value
82	Inhibitors
30	Ki Value [mM]
6	KM Value [mM]
40	Localization
10	Metals/Ions
9	Molecular Weight [Da]
40	Natural Substrates/ Products (Substrates)
203	Organism
4	Pathway
74	PDB ID
3	pH Optimum
3	Posttranslational Modification
9	Protein Variants
12	Purification (Commentary)
1	Reaction
3	Reaction Type
39	Reference
70	Source Tissue
3	Specific Activity [micromol/min/mg]
46	Substrates and Products (Substrate)
8	Subunits
133	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
3	Turnover Number [1/s]

Localization

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Localization on EC 2.7.1.149 - 1-phosphatidylinositol-5-phosphate 4-kinase

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endoplasmic reticulum

partial Golgi localization, primarily the matrix of the cis-Golgi

PI5P4Kalpha is membrane-bound in DT40 cells with a significant amount of endogenous PI5P4Kalpha in the nucleus

photoreceptor inner segment

2 entries

photoreceptor outer segment

3 entries

photoreceptor outer segment membrane

isoform PI5P4Kgamma

additional information

Mammalia

analysis of subcellular localization of native and recombinant isozyme PI5P4Kalpha, overview

721247