2.6.1.85: aminodeoxychorismate synthase

This is an abbreviated version!
For detailed information about aminodeoxychorismate synthase, go to the full flat file.

Reaction

Synonyms

4-amino-4-deoxychorismate synthase, ADC, ADC synthase, ADCS, aminodeoxychorismate synthase, chorismate:L-glutamine amido-ligase, EC 6.3.5.8, PabA, PabAB, PabB, PhzE, PvADCS

ECTree

     2 Transferases

         2.6 Transferring nitrogenous groups

             2.6.1 Transaminases

                2.6.1.85 aminodeoxychorismate synthase

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Results	in table
3	Activating Compound
19421	AA Sequence
1	Application
1	CAS Registry Number
8	Cloned(Commentary)
2	Crystallization (Commentary)
6	General Information
10	Inhibitors
8	kcat/KM [mM/s]
4	Ki Value [mM]
18	KM Value [mM]
1	Localization
8	Metals/Ions
4	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
21	Organism
5	Pathway
5	PDB ID
2	pH Optimum
10	Protein Variants
6	Purification (Commentary)
10	Reaction
2	Reaction Type
18	Reference
2	Storage Stability
21	Substrates and Products (Substrate)
6	Subunits
27	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
18	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 2.6.1.85 - aminodeoxychorismate synthase

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SYSTEMATIC NAME

IUBMB Comments

chorismate:L-glutamine aminotransferase

The enzyme is composed of two parts, a glutaminase (PabA in Escherichia coli) and an aminotransferase (PabB). In the absence of PabA and glutamine (but in the presence of Mg2+), PabB can convert ammonia and chorismate into 4-amino-4-deoxychorismate. PabA converts glutamine into glutamate only in the presence of stoichiometric amounts of PabB. In many organisms, including plants, the genes encoding the two proteins have fused to encode a single bifunctional protein. This enzyme is coupled with EC 4.1.3.38, aminodeoxychorismate lyase, to form 4-aminobenzoate. cf. EC 2.6.1.123, 4-amino-4-deoxychorismate synthase (2-amino-4-deoxychorismate-forming).