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Information on EC 2.6.1.85 - aminodeoxychorismate synthase

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EC Tree
     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.85 aminodeoxychorismate synthase
IUBMB Comments
The enzyme is composed of two parts, a glutaminase (PabA in Escherichia coli) and an aminotransferase (PabB). In the absence of PabA and glutamine (but in the presence of Mg2+), PabB can convert ammonia and chorismate into 4-amino-4-deoxychorismate. PabA converts glutamine into glutamate only in the presence of stoichiometric amounts of PabB. In many organisms, including plants, the genes encoding the two proteins have fused to encode a single bifunctional protein. This enzyme is coupled with EC 4.1.3.38, aminodeoxychorismate lyase, to form 4-aminobenzoate. cf. EC 2.6.1.123, 4-amino-4-deoxychorismate synthase (2-amino-4-deoxychorismate-forming).
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Reaction Schemes
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Synonyms
aminodeoxychorismate synthase, pabab, 4-amino-4-deoxychorismate synthase, adc synthase, pvadcs, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate
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chorismate + NH3 = 4-amino-4-deoxychorismate + H2O
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(1b)
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L-glutamine + H2O = L-glutamate + NH3
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(1a)
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PATHWAY SOURCE
PATHWAYS
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