2.6.1.85: aminodeoxychorismate synthase

This is an abbreviated version!
For detailed information about aminodeoxychorismate synthase, go to the full flat file.

Reaction

Synonyms

4-amino-4-deoxychorismate synthase, ADC, ADC synthase, ADCS, aminodeoxychorismate synthase, chorismate:L-glutamine amido-ligase, EC 6.3.5.8, PabA, PabAB, PabB, PhzE, PvADCS

ECTree

     2 Transferases

         2.6 Transferring nitrogenous groups

             2.6.1 Transaminases

                2.6.1.85 aminodeoxychorismate synthase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
3	Activating Compound
19421	AA Sequence
1	Application
1	CAS Registry Number
8	Cloned(Commentary)
2	Crystallization (Commentary)
6	General Information
10	Inhibitors
8	kcat/KM [mM/s]
4	Ki Value [mM]
18	KM Value [mM]
1	Localization
8	Metals/Ions
4	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
21	Organism
5	Pathway
5	PDB ID
2	pH Optimum
10	Protein Variants
6	Purification (Commentary)
10	Reaction
2	Reaction Type
18	Reference
2	Storage Stability
21	Substrates and Products (Substrate)
6	Subunits
27	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
18	Turnover Number [1/s]

Application

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Application on EC 2.6.1.85 - aminodeoxychorismate synthase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Application Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

biotechnology

Escherichia coli

P00903

conversion of aminodeoxychorismate synthase into anthranilate synthase employing a bioinformatics method for predicting mutations required to functionally interconvert homologous enzymes. Complementation of an anthranilate synthase-deficient strain of Escherichia coli grown on minimal medium leads to several aminodeoxychorismate synthase mutants that allow growth in 6 days compared to 2 days for wild-type anthranilate synthase. The purified mutant enzymes catalyze the conversion of chorismate to anthranilate at rates that are about 50% of the rate of wild-type aminodeoxychorismate synthase-catalyzed conversion of chorismate to aminodeoxychorismate. The residues mutated do not contact the substrate

737705