2.4.2.54: beta-ribofuranosylphenol 5'-phosphate synthase

This is an abbreviated version!
For detailed information about beta-ribofuranosylphenol 5'-phosphate synthase, go to the full flat file.

Reaction

Synonyms

4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase, AF2089, beta-RFA-P synthase, beta-RFAP synthase, beta-ribofuranosyl-aminobenzene 5'-phosphate synthase, beta-ribofuranosylaminobenzene 5'-phosphate synthase, beta-ribofuranosylhydroxybenzene 5'-phosphate synthase, ForT, MTH0830, PrfT, RFAP synthase, ribofuranosylaminobenzene 5'-phosphate synthase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.2 Pentosyltransferases

                2.4.2.54 beta-ribofuranosylphenol 5'-phosphate synthase

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Results	in table
1233	AA Sequence
5	Cloned(Commentary)
1	Cofactor
3	General Information
1	General Stability
16	Inhibitors
6	Ki Value [mM]
8	KM Value [mM]
6	Metals/Ions
9	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
11	Organism
1	Oxidation Stability
4	Pathway
5	pH Optimum
3	pH Stability
4	Protein Variants
8	Purification (Commentary)
1	Reaction
11	Reference
6	Specific Activity [micromol/min/mg]
20	Substrates and Products (Substrate)
5	Subunits
27	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
1	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 2.4.2.54 - beta-ribofuranosylphenol 5'-phosphate synthase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate

4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate

2 entries

5-phospho-alpha-D-ribose 1-diphosphate + 4-amino-3,5-dicarboxypyrazole

4-amino-3-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(oxophosphanyl)oxolan-2-yl]-1H-pyrazole-5-carboxylic acid + CO2 + diphosphate

2 entries

5-phospho-alpha-D-ribose 1-diphosphate + 4-aminobenzoate

4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate

5 entries

5-phospho-alpha-D-ribose 1-diphosphate + 4-aminobenzoate

4-(beta-D-ribofuranosyl)aniline 5'-phosphate + CO2 + diphosphate

2 entries

5-phospho-alpha-D-ribose 1-diphosphate + 4-aminobenzoate

beta-ribofuranosylaminobenzene 5'-phosphate + CO2 + diphosphate

Methanothermobacter thermautotrophicus

-

-

755756

-

-

?

5-phospho-alpha-D-ribose 1-diphosphate + 4-hydroxy-3,5-dicarboxypyrazole

3-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(oxophosphanyl)oxolan-2-yl]-4-hydroxy-1H-pyrazole-5-carboxylic acid + CO2 + diphosphate

2 entries

5-phospho-alpha-D-ribose 1-diphosphate + 4-hydroxybenzoate

4-(beta-D-ribofuranosyl)hydroxybenzene 5'-phosphate + CO2 + diphosphate

Methanosarcina thermophila

-

sequential pattern of substrate binding

718828

-

-

?

5-phospho-alpha-D-ribose 1-diphosphate + 4-hydroxybenzoate

4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate

4 entries

4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate

4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate

Archaeoglobus fulgidus

O28190

-

719699

-

-

?

4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate

4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate

Archaeoglobus fulgidus

O28190

the enzyme is involved in biosynthesis of tetrahydromethanopterin, a folate analog involved in the C1 metabolism of methanogenic archaea, sulfate-reducing archaea, and methylotrophic bacteria

719699

-

-

?

5-phospho-alpha-D-ribose 1-diphosphate + 4-amino-3,5-dicarboxypyrazole

4-amino-3-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(oxophosphanyl)oxolan-2-yl]-1H-pyrazole-5-carboxylic acid + CO2 + diphosphate

Streptomyces candidus

-

-

758670

-

-

?

5-phospho-alpha-D-ribose 1-diphosphate + 4-amino-3,5-dicarboxypyrazole

4-amino-3-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(oxophosphanyl)oxolan-2-yl]-1H-pyrazole-5-carboxylic acid + CO2 + diphosphate

Streptomyces candidus NRRL 3601

-

-

758670

-

-

?

5-phospho-alpha-D-ribose 1-diphosphate + 4-aminobenzoate

4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate

Methanocaldococcus jannaschii

Q58822

the enzyme is involved in biosynthesis of tetrahydromethanopterin, a folate analog involved in the C1 metabolism of methanogenic archaea, sulfate-reducing archaea, and methylotrophic bacteria

719820

-

-

?

5-phospho-alpha-D-ribose 1-diphosphate + 4-aminobenzoate

4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate

Methanocaldococcus jannaschii

Q58822

ordered Bi-Ter mechanism involving binding of 5-phospho-alpha-D-ribose 1-diphosphate, then 4-aminobenzoate, followed by release of the products CO2, then 4-(beta-D-ribofuranosyl)aminobenzene-5'-phosphate, and finally diphosphate

719820

-

-

?

5-phospho-alpha-D-ribose 1-diphosphate + 4-aminobenzoate

4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate

Methanosarcina thermophila

-

-

719699

-

-

?

5-phospho-alpha-D-ribose 1-diphosphate + 4-aminobenzoate

4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate

Methanosarcina thermophila

-

the enzyme is involved in biosynthesis of tetrahydromethanopterin, a folate analog involved in the C1 metabolism of methanogenic archaea, sulfate-reducing archaea, and methylotrophic bacteria

718828, 719699

-

-

?

5-phospho-alpha-D-ribose 1-diphosphate + 4-aminobenzoate

4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate

Methanosarcina thermophila

-

sequential pattern of substrate binding. An SN1-like reaction produces oxonium ion character at C-1 of 5-phospho-alpha-D-ribose 1-diphosphate which undergoes an ipso electrophilic aromatic substitution reaction at the carboxylic acid-bound carbon of 4-aminobenzoate. Decarboxylation of the resulting cyclohexadienimine intermediate leads to the formation of 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate

718828

-

-

?

5-phospho-alpha-D-ribose 1-diphosphate + 4-aminobenzoate

4-(beta-D-ribofuranosyl)aniline 5'-phosphate + CO2 + diphosphate

Archaeoglobus fulgidus

O28190

-

721780

-

-

?

5-phospho-alpha-D-ribose 1-diphosphate + 4-aminobenzoate

4-(beta-D-ribofuranosyl)aniline 5'-phosphate + CO2 + diphosphate

Methylorubrum extorquens

-

-

721780

-

-

?

5-phospho-alpha-D-ribose 1-diphosphate + 4-hydroxy-3,5-dicarboxypyrazole

3-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(oxophosphanyl)oxolan-2-yl]-4-hydroxy-1H-pyrazole-5-carboxylic acid + CO2 + diphosphate

Streptomyces kaniharaensis

-

-

758670

-

-

?

5-phospho-alpha-D-ribose 1-diphosphate + 4-hydroxy-3,5-dicarboxypyrazole

3-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(oxophosphanyl)oxolan-2-yl]-4-hydroxy-1H-pyrazole-5-carboxylic acid + CO2 + diphosphate

Streptomyces kaniharaensis ATCC 21070

-

-

758670

-

-

?

5-phospho-alpha-D-ribose 1-diphosphate + 4-hydroxybenzoate

4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate

Streptomyces candidus

-

-

758670

-

-

?

5-phospho-alpha-D-ribose 1-diphosphate + 4-hydroxybenzoate

4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate

Streptomyces candidus NRRL 3601

-

-

758670

-

-

?

5-phospho-alpha-D-ribose 1-diphosphate + 4-hydroxybenzoate

4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate

Streptomyces kaniharaensis

-

-

758670

-

-

?

5-phospho-alpha-D-ribose 1-diphosphate + 4-hydroxybenzoate

4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate

Streptomyces kaniharaensis ATCC 21070

-

-

758670

-

-

?