2.4.2.54: beta-ribofuranosylphenol 5'-phosphate synthase

This is an abbreviated version!
For detailed information about beta-ribofuranosylphenol 5'-phosphate synthase, go to the full flat file.

Word Map on EC 2.4.2.54

2.4.2.54

tetrahydromethanopterin

p-aminobenzoic

methanopterin

methanogen

pyrophosphate

co2

paba

archaea

one-carbon

methane

methane-producing

bi-ter

jannaschii

methanosarcina

thermophila

pyridoxal

fulgidus

folate

methanococcus

phosphoribosyltransferases

tetrahydrofolate

thermautotrophicus

extorquens

archaeoglobus

greenhouse

methanothermobacter

methylobacterium

n-riboside

Reaction

4-(beta-D-ribofuranosyl)phenol 5'-phosphate

Synonyms

4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase, AF2089, beta-RFA-P synthase, beta-RFAP synthase, beta-ribofuranosyl-aminobenzene 5'-phosphate synthase, beta-ribofuranosylaminobenzene 5'-phosphate synthase, beta-ribofuranosylhydroxybenzene 5'-phosphate synthase, ForT, MTH0830, PrfT, RFAP synthase, ribofuranosylaminobenzene 5'-phosphate synthase

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.2 Pentosyltransferases

2.4.2.54 beta-ribofuranosylphenol 5'-phosphate synthase

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Results	in table
1233	AA Sequence
5	Cloned(Commentary)
1	Cofactor
3	General Information
1	General Stability
16	Inhibitors
6	Ki Value [mM]
8	KM Value [mM]
6	Metals/Ions
9	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
11	Organism
1	Oxidation Stability
4	Pathway
5	pH Optimum
3	pH Stability
4	Protein Variants
8	Purification (Commentary)
1	Reaction
11	Reference
6	Specific Activity [micromol/min/mg]
20	Substrates and Products (Substrate)
5	Subunits
27	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
1	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 2.4.2.54 - beta-ribofuranosylphenol 5'-phosphate synthase

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4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate

Methanocaldococcus jannaschii

Q58822

uncompetitive inhibition under varied 5-phospho-alpha-D-ribose 1-diphosphate and saturated 4-aminobenzoate or under varied 4-aminobenzoate and saturated 5-phospho-alpha-D-ribose 1-diphosphate

719820

4-(methylamino)benzoic acid

Methanosarcina thermophila

5 mM, complete loss of activity

718828

4-aminothiobenzoate

Methanosarcina thermophila

5 mM, 24% loss of activity

718828

4-Bromobenzoate

Methanosarcina thermophila

5 mM, 60% loss of activity

718828

4-hydroxybenzoate

Methanosarcina thermophila

5 mM, 88% loss of activity

718828

4-Methoxybenzoate

Methanosarcina thermophila

5 mM, 55% loss of activity

718828

4-methylaminobenzoate

Archaeoglobus fulgidus

O28190

5 mM, 26% inhibition

721780

benzoate

Methanosarcina thermophila

5 mM, 31% loss of activity

718828

CO2

Methanocaldococcus jannaschii

Q58822

uncompetitive inhibition under varied 5-phospho-alpha-D-ribose 1-diphosphate and saturated 4-aminobenzoate. Mixed type of inhibition under varied 4-aminobenzoate and saturated 5-phospho-alpha-D-ribose 1-diphosphate

719820

diphosphate

2 entries

phosphate

Methanosarcina thermophila

10 mM, 37% inhibition

718828

pyridoxal 5'-phosphate

Methanosarcina thermophila

2.5 mM, 21% inhibition

718828

ribose 5-phosphate

Methanosarcina thermophila

10 mM, 20% inhibition

718828

Sodium cyanoborohydride

Methanosarcina thermophila

160 mM, complete inhibition, decreased production of 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate and the accumulation of a reduced form of the proposed cyclohexadienimine reaction intermediates

718828

additional information

Methanosarcina thermophila

no inhibition by carbonyl reagents, 4-aminobenzoic acid methyl ester, aniline, 4-aminobenzamide

718828