2.4.1.165: N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase

This is an abbreviated version!
For detailed information about N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase, go to the full flat file.

Reaction

Synonyms

acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-acetylneuraminyl(alpha2-->3)galactosyl(beta1-->4)glucosyl beta1-->4-, beta-1,4-N-acetylgalactosyltransferase II, beta4GalNAc-T, beta4GalNAcT-II, CT GalNAc transferase, cytotoxic T cell GalNAc transferase, Galgt2, More, Sd(alpha) beta4GalNAcT-II, Sda-beta-1,4-N-acetylgalactosaminyltransferase, Sda-beta-GalNAc-transferase, UDP-GalNAc:beta1,4-N-acetylgalactosaminyltransferase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.165 N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase

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4	Activating Compound
1	AA Sequence
3	Application
1	CAS Registry Number
2	Cloned(Commentary)
68	Disease/ Diagnostics
4	Inhibitors
7	KM Value [mM]
3	Localization
4	Metals/Ions
8	Natural Substrates/ Products (Substrates)
13	Organism
3	pH Optimum
1	pH Range
1	Posttranslational Modification
1	Purification (Commentary)
1	Reaction
1	Reaction Type
13	Reference
28	Source Tissue
1	Storage Stability
45	Substrates and Products (Substrate)
1	Subunits
13	Synonyms
1	Systematic Name

Substrates Products

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Substrates Products on EC 2.4.1.165 - N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

UDP-N-acetyl-D-galactosamine + alpha(2-3)-sialylated glycoprotein

UDP + GalNAc-beta(1-4)(Neu5Ac(2-3))Gal-beta-1-protein

Homo sapiens

Q8NHY0

-

657827

-

-

?

UDP-N-acetyl-D-galactosamine + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

7 entries

UDP-N-acetyl-D-galactosamine + alpha1-acid glycoprotein

UDP + N-acetylgalactosaminyl-alpha1-acid glycoprotein

2 entries

UDP-N-acetyl-D-galactosamine + asialofetuin

UDP + N-acetylgalactosaminylasialofetuin

2 entries

UDP-N-acetyl-D-galactosamine + di-sialyl-lacto-N-tetraose

UDP + N-acetylgalactosaminyl-di-sialyl-lacto-N-tetraose

Homo sapiens

-

-

488682

-

-

?

UDP-N-acetyl-D-galactosamine + fetuin

UDP + ?

Homo sapiens

Q8NHY0

-

657827

-

-

?

UDP-N-acetyl-D-galactosamine + fetuin

UDP + N-acetylgalactosaminylfetuin

2 entries

UDP-N-acetyl-D-galactosamine + glycophorin

UDP + N-acetylgalactosaminyl glycophorin

Homo sapiens

-

good acceptor

488679

-

-

?

UDP-N-acetyl-D-galactosamine + glycophorin A

UDP + N-acetylgalactosaminyl glycophorin A

Homo sapiens

-

weak activity

488678

-

-

?

UDP-N-acetyl-D-galactosamine + human chorionic gonadotropin

UDP + N-acetylgalactosaminyl human chorionic gonadotropin

2 entries

UDP-N-acetyl-D-galactosamine + Neu5Ac-alpha(2-3)Gal-beta(1-3)GlcNAc-beta-1-O-benzyl

UDP + ?

Homo sapiens

Q8NHY0

-

657827

-

-

?

UDP-N-acetyl-D-galactosamine + NeuAcalpha(2-3)Galbeta(1-4)Glc

UDP + GalNAcbeta(1-4)(NeuAcalpha(2-3))Galbeta(1-4)Glc

7 entries

UDP-N-acetyl-D-galactosamine + NeuAcalpha(2-3)Galbeta(1-4)GlcNAc

UDP + GalNAcbeta(1-4)(NeuAcalpha(2-3))Galbeta(1-4)Glc

3 entries

additional information

?

-

5 entries

UDP-N-acetyl-D-galactosamine + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

Homo sapiens

-

-

488678, 488681

-

-

?

UDP-N-acetyl-D-galactosamine + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

Homo sapiens

-

enzymic activity correlates with the degree of enterocytic differentiation

488682

-

-

?

UDP-N-acetyl-D-galactosamine + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

Homo sapiens

-

responsible for addition of the immunodominant sugar of the Sda-isto-blood-group determinant

488679

-

488679

?

UDP-N-acetyl-D-galactosamine + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

Mus musculus

-

-

701621

-

-

?

UDP-N-acetyl-D-galactosamine + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

Mus musculus

-

overexpression of the enzyme in skeletal muscles inhibits muscular dystrophy in mdx mice. The enzyme produces the terminal beta1,4GalNAc linkage on the cytotoxic T cell carbohydrate antigen which is also localized to the neuromuscular junction in adult animals

488683

-

-

?

UDP-N-acetyl-D-galactosamine + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

Mus musculus

-

the enzyme can affect the post-translational processing of dystroglycan and the extent of muscular dystrophy even in muscles where the VIA4-1 antigen is not present

488684

-

-

?

UDP-N-acetyl-D-galactosamine + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

Sus scrofa

-

-

488681

-

-

?

UDP-N-acetyl-D-galactosamine + alpha1-acid glycoprotein

UDP + N-acetylgalactosaminyl-alpha1-acid glycoprotein

Homo sapiens

-

-

488678, 488681

-

-

?

UDP-N-acetyl-D-galactosamine + alpha1-acid glycoprotein

UDP + N-acetylgalactosaminyl-alpha1-acid glycoprotein

Sus scrofa

-

-

488681

-

-

?

UDP-N-acetyl-D-galactosamine + asialofetuin

UDP + N-acetylgalactosaminylasialofetuin

Homo sapiens

-

-

488678, 488679, 488681, 488682

-

-

?

UDP-N-acetyl-D-galactosamine + asialofetuin

UDP + N-acetylgalactosaminylasialofetuin

Sus scrofa

-

-

488681

-

-

?

UDP-N-acetyl-D-galactosamine + fetuin

UDP + N-acetylgalactosaminylfetuin

Homo sapiens

-

-

488678, 488679, 488681, 488682

-

-

?

UDP-N-acetyl-D-galactosamine + fetuin

UDP + N-acetylgalactosaminylfetuin

Sus scrofa

-

-

488681

-

-

?

UDP-N-acetyl-D-galactosamine + human chorionic gonadotropin

UDP + N-acetylgalactosaminyl human chorionic gonadotropin

Homo sapiens

-

-

488679, 488681

-

-

?

UDP-N-acetyl-D-galactosamine + human chorionic gonadotropin

UDP + N-acetylgalactosaminyl human chorionic gonadotropin

Sus scrofa

-

-

488681

-

-

?

UDP-N-acetyl-D-galactosamine + NeuAcalpha(2-3)Galbeta(1-4)Glc

UDP + GalNAcbeta(1-4)(NeuAcalpha(2-3))Galbeta(1-4)Glc

Homo sapiens

-

-

488680

-

-

?

UDP-N-acetyl-D-galactosamine + NeuAcalpha(2-3)Galbeta(1-4)Glc

UDP + GalNAcbeta(1-4)(NeuAcalpha(2-3))Galbeta(1-4)Glc

Homo sapiens

-

-

488681

-

488681

?

UDP-N-acetyl-D-galactosamine + NeuAcalpha(2-3)Galbeta(1-4)Glc

UDP + GalNAcbeta(1-4)(NeuAcalpha(2-3))Galbeta(1-4)Glc

Homo sapiens

-

-

488682

-

-

?

UDP-N-acetyl-D-galactosamine + NeuAcalpha(2-3)Galbeta(1-4)Glc

UDP + GalNAcbeta(1-4)(NeuAcalpha(2-3))Galbeta(1-4)Glc

Homo sapiens

-

strictly requires the presence of sialic acid in alpha-2,3-linkage to subterminal galactose

488679

-

-

?

UDP-N-acetyl-D-galactosamine + NeuAcalpha(2-3)Galbeta(1-4)Glc

UDP + GalNAcbeta(1-4)(NeuAcalpha(2-3))Galbeta(1-4)Glc

Homo sapiens

-

i.e. 3'-sialyllactose

488678

-

488678

?

UDP-N-acetyl-D-galactosamine + NeuAcalpha(2-3)Galbeta(1-4)Glc

UDP + GalNAcbeta(1-4)(NeuAcalpha(2-3))Galbeta(1-4)Glc

Homo sapiens

Q8NHY0

responsible for the final step in the formation of the Sda/Cad antigenic epitopes, Sd(alpha) beta4GalNAcT-II mRNA transcript is drastically reduced in oncogenetic processes in gastrointestinal tissues

686976

-

-

?

UDP-N-acetyl-D-galactosamine + NeuAcalpha(2-3)Galbeta(1-4)Glc

UDP + GalNAcbeta(1-4)(NeuAcalpha(2-3))Galbeta(1-4)Glc

Sus scrofa

-

-

488681

-

488681

?

UDP-N-acetyl-D-galactosamine + NeuAcalpha(2-3)Galbeta(1-4)GlcNAc

UDP + GalNAcbeta(1-4)(NeuAcalpha(2-3))Galbeta(1-4)Glc

Homo sapiens

-

-

488682

-

-

?

UDP-N-acetyl-D-galactosamine + NeuAcalpha(2-3)Galbeta(1-4)GlcNAc

UDP + GalNAcbeta(1-4)(NeuAcalpha(2-3))Galbeta(1-4)Glc

Homo sapiens

-

i.e. 3'-sialyllactosamine

488681

-

-

?

UDP-N-acetyl-D-galactosamine + NeuAcalpha(2-3)Galbeta(1-4)GlcNAc

UDP + GalNAcbeta(1-4)(NeuAcalpha(2-3))Galbeta(1-4)Glc

Sus scrofa

-

-

488681

-

488681

?

additional information

?

-

Homo sapiens

-

-

488681

-

-

?

additional information

?

-

Homo sapiens

-

the enzyme strictly requires the presence in acceptors of NeuAc in alpha2,3-linkage to subterminal galactose

488682

-

-

?

additional information

?

-

Homo sapiens

Q8NHY0

involved in formation of blood group Sda/CAD antigen

657827

-

-

?

additional information

?

-

Homo sapiens

Q8NHY0

analysis of acceptor substrate specificity, no substrate: ganglioside GM3, 3’-sulfolactose, 3’-O-methylcarboxyllactose

657827

-

-

?

additional information

?

-

Sus scrofa

-

the enzyme strictly recognizes the NeuAcalpha2,3Galbeta terminal sequence of N- and O-linked oligosaccharides bound to glycoproteins

488681

-

-

?