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2.4.1.150: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase

This is an abbreviated version!
For detailed information about N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase, go to the full flat file.

Word Map on EC 2.4.1.150

Reaction

UDP-N-acetyl-alpha-D-glucosamine
+
beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-R
=
UDP
 +
beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-R

Synonyms

2beta-1,6-acetylglucosaminyltransferase, acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-acetyllactosaminide beta1-->6-, beta1-6GnT, C2/4GnT, C24GNT, C2GnT, C2GnT2, C2GNTM, core 2 beta-1,6-N-acetylglucosaminyltransferase, core 2beta-1,6-acetylglucosaminyltransferase, dIHnT, distally acting I-branching beta1,6-N-acetylglucosaminyltransferase, EC 2.4.1.164, Galbeta1-->4GlcNAc-R beta1-->6 N-acetylglucosaminyltransferase, GCNT2, Gcnt2 gene product, gcnt3, glucosaminyl (N-acetyl) transferase 2, GNTM, I beta1,6-N-acetylglucosaminyltransferase, I N-acetylglucosaminyltransferase, I-branching beta-1,6-N-acetylglucosaminyl transferase 2, I-branching beta-1,6-N-acetylglucosaminyltransferase, I-branching enzyme, I-branching N-acetylglucosaminyltransferase, IGnT, More, N-acetylglucosaminyltransferase, N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, UDP-GlcNAc:Gal-R, beta-D-6-N-acetylglucosaminyltransferase, UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminide 6-beta-N-acetyl-D-glucosaminyltransferase, uridine diphosphoacetylglucosamine-acetyllactosaminide beta1-->6-acetylglucosaminyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.150 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase

Application

Application on EC 2.4.1.150 - N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase

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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
diagnostics
medicine
GCNT2 is overexpressed in highly metastatic breast cancer and its expression correlates with adverse pathologic phenotypes. Blocking TGF-beta/GCNT2 signaling is a promising approach for targeting metastatic breast cancer
pharmacology
targeting mucin biosynthesis through GCNT3 may improve drug responsiveness
synthesis
-
cIGnT6 transfers multiple GlcNAc branches to long linear polylactosamines, a prerequisite for improving enzyme-assisted in vitro synthesis of a type of multivalent sialyl Lewis x glycans that are high affinity inhibitors of lymphocyte L-selectin, enzyme allows general polylactosamine synthesis