2.4.1.149: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase

This is an abbreviated version!
For detailed information about N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, go to the full flat file.

Reaction

Synonyms

acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-acetyllactosaminide beta1-->3-, B3gnt1, B3GNT3, beta-1,3-N-acetylglucosaminyltransferase 1, beta-1,3-N-acetylglucosaminyltransferase-3, beta1,3-N-acetylglucosaminyltransferase, beta1,3-N-acetylglucosaminyltransferase-7, beta1-3 N-acetylglucosaminyltransferase-1, beta3-N-acetylglucosaminyltransferase 1, beta3GlcNAcT, beta3Gn-T7, beta3GnT1, beta3GnT7, EC 2.4.1.163, Galbeta1-->4GlcNAc-R beta1-->3 N-acetylglucosaminyltransferase, GnT-I, i-GlcNAc transferase, i-GlcNAcT, IGnT, JHP1032, N-acetyllactosamine beta(1-3)N-acetylglucosaminyltransferase, poly-N-acetyllactosamine extension enzyme, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1, UDP-GlcNAc:Galbeta1-->4GlcNAcbeta-Rbeta1-->3-N-acetylglucosaminyltransferase, UDP-GlcNAc:Galbeta1-4Glc(NAc) beta-1,3-N-acetylglucosaminyltransferase, UDP-GlcNAc:GalR, beta-D-3-N-acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-acetyllactosaminide beta1-->3-acetylglucosaminyltransferase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.149 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase

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Results	in table
12	Activating Compound
23	AA Sequence
3	Application
1	CAS Registry Number
6	Cloned(Commentary)
113	Disease/ Diagnostics
2	Expression
2	General Information
19	Inhibitors
25	KM Value [mM]
7	Localization
20	Metals/Ions
4	Molecular Weight [Da]
24	Natural Substrates/ Products (Substrates)
21	Organism
6	Pathway
23	PDB ID
9	pH Optimum
1	pH Range
3	Posttranslational Modification
2	Purification (Commentary)
1	Reaction
1	Reaction Type
21	Reference
43	Source Tissue
3	Specific Activity [micromol/min/mg]
2	Storage Stability
95	Substrates and Products (Substrate)
4	Subunits
29	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]
8	Temperature Stability [°C]

KM Value

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KM Value on EC 2.4.1.149 - N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.6

asialo-alpha1-acid glycoprotein

Rattus norvegicus

-

-

638577

-

0.44 - 0.9

Galbeta(1-4)GlcNAcbeta(1-4)GlcNAc-2-aminopyridine

2 entries

1

Galbeta(1->4)GlcNAcbeta(1->3)Galbeta(1->4)GlcNAc

Rattus norvegicus

-

-

638577

0.36

Galbeta1,4(SO3-,6)-GlcNAcbeta1,3-Galbeta1,4(SO3-,6)-GlcNAc

Homo sapiens

-

recombinant enzyme, pH 7.2, 37°C

658728

0.19

lactoneotetraosylceramide

Homo sapiens

-

-

638576

0.19

lactonorhexaosylceramide

Homo sapiens

-

-

638576

-

5.2 - 29.8

lactose

3 entries

2.2 - 19.6

N-acetyllactosamine

3 entries

0.09

neolactotetraosylceramide

Mus musculus

-

-

638606

0.129 - 15.97

UDP-N-acetyl-D-glucosamine

10 entries

additional information

additional information

Rattus norvegicus

-

-

638577

-

0.44

Galbeta(1-4)GlcNAcbeta(1-4)GlcNAc-2-aminopyridine

Rattus norvegicus

-

PC-12 cells

638580

0.9

Galbeta(1-4)GlcNAcbeta(1-4)GlcNAc-2-aminopyridine

Rattus norvegicus

-

PC-12D cells

638580

5.2

lactose

Rattus norvegicus

-

-

638577

18.2

lactose

Bos taurus

-

-

638578

29.8

lactose

Homo sapiens

-

-

638575

2.2

N-acetyllactosamine

Rattus norvegicus

-

-

638577

7

N-acetyllactosamine

Homo sapiens

-

-

638575

19.6

N-acetyllactosamine

Bos taurus

-

-

638578

0.129

UDP-N-acetyl-D-glucosamine

Bos taurus

-

-

638578

0.133

UDP-N-acetyl-D-glucosamine

Homo sapiens

-

lactose as acceptor

638575

0.17

UDP-N-acetyl-D-glucosamine

Homo sapiens

-

lactosylceramide as acceptor

638576

0.33

UDP-N-acetyl-D-glucosamine

Mus musculus

-

solubilized enzyme

638606

1.445

UDP-N-acetyl-D-glucosamine

Helicobacter pylori

-

using Galbeta(1->3)[GlcNAcbeta(1->6)]GalNAcalpha-OCH(CH3)CH(NH2)CO2H as acceptor, in cacodylate buffer (100 mM, pH 7.5), at 37°C

722360

1.487

UDP-N-acetyl-D-glucosamine

Helicobacter pylori

-

using Galbeta(1->4)GlcNAcbeta-O(CH2)3N3 as acceptor, in cacodylate buffer (100 mM, pH 7.5), at 37°C

722360

2.082

UDP-N-acetyl-D-glucosamine

Helicobacter pylori

-

using Galbeta(1->3)GalNAcalpha-OCH(CH3)CH(NH2)CO2H as acceptor, in cacodylate buffer (100 mM, pH 7.5), at 37°C

722360

2.5

UDP-N-acetyl-D-glucosamine

Mus musculus

-

membrane-bound enzyme

638606

8

UDP-N-acetyl-D-glucosamine

Rattus norvegicus

-

PC-12 and PC-12D cells

638580

15.97

UDP-N-acetyl-D-glucosamine

Helicobacter pylori

-

using Galbeta(1->3)GlcNAcbeta-O(CH2)3N3 as acceptor, in cacodylate buffer (100 mM, pH 7.5), at 37°C

722360