2.4.1.149: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase

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For detailed information about N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, go to the full flat file.

Reaction

Synonyms

acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-acetyllactosaminide beta1-->3-, B3gnt1, B3GNT3, beta-1,3-N-acetylglucosaminyltransferase 1, beta-1,3-N-acetylglucosaminyltransferase-3, beta1,3-N-acetylglucosaminyltransferase, beta1,3-N-acetylglucosaminyltransferase-7, beta1-3 N-acetylglucosaminyltransferase-1, beta3-N-acetylglucosaminyltransferase 1, beta3GlcNAcT, beta3Gn-T7, beta3GnT1, beta3GnT7, EC 2.4.1.163, Galbeta1-->4GlcNAc-R beta1-->3 N-acetylglucosaminyltransferase, GnT-I, i-GlcNAc transferase, i-GlcNAcT, IGnT, JHP1032, N-acetyllactosamine beta(1-3)N-acetylglucosaminyltransferase, poly-N-acetyllactosamine extension enzyme, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1, UDP-GlcNAc:Galbeta1-->4GlcNAcbeta-Rbeta1-->3-N-acetylglucosaminyltransferase, UDP-GlcNAc:Galbeta1-4Glc(NAc) beta-1,3-N-acetylglucosaminyltransferase, UDP-GlcNAc:GalR, beta-D-3-N-acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-acetyllactosaminide beta1-->3-acetylglucosaminyltransferase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.149 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase

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Results	in table
12	Activating Compound
23	AA Sequence
3	Application
1	CAS Registry Number
6	Cloned(Commentary)
113	Disease/ Diagnostics
2	Expression
2	General Information
19	Inhibitors
25	KM Value [mM]
7	Localization
20	Metals/Ions
4	Molecular Weight [Da]
24	Natural Substrates/ Products (Substrates)
21	Organism
6	Pathway
23	PDB ID
9	pH Optimum
1	pH Range
3	Posttranslational Modification
2	Purification (Commentary)
1	Reaction
1	Reaction Type
21	Reference
43	Source Tissue
3	Specific Activity [micromol/min/mg]
2	Storage Stability
95	Substrates and Products (Substrate)
4	Subunits
29	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]
8	Temperature Stability [°C]

Cloned

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Cloned on EC 2.4.1.149 - N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

cDNA from melanoma and colonic cancer cells is cloned and overexpressed in human Burkitt lymphoma Namalwa KJM-1 cells overexpressing the i-antigen, nucleotide and amino acid sequence of the 415-amino acids protein, cDNA fragment encoding the stem region plus putative catalytic domain of iGnT fused to protein A is expressed in COS-1 cells

Homo sapiens

O43505

638582

cDNA from placenta encoding beta3GnT7 is cloned and partially characterized, open reading frame encodes a 397-amino acids protein

Mus musculus

Q8K0J2

638581

expression in COS-7 cells, localization in membranes

Homo sapiens

-

658728

gene B3GNT3, real-time PCR enzyme expression analysis

Homo sapiens

Q9Y2A9

759552

human ortholog to mouse enzyme beta3GnT7 has the chromosomal locus 2q37.1

Homo sapiens

Q8NFL0

638581

plasmid cDNA encoding the catalytic domain of i-GlcNAcT, amino acids 53-415, is expressed in COS-1 cells

Homo sapiens

-

638579