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2.4.1.149: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase

This is an abbreviated version!
For detailed information about N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, go to the full flat file.

Word Map on EC 2.4.1.149

Reaction

UDP-N-acetyl-alpha-D-glucosamine
+
beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R
=
UDP
 +
N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R

Synonyms

acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-acetyllactosaminide beta1-->3-, B3gnt1, B3GNT3, beta-1,3-N-acetylglucosaminyltransferase 1, beta-1,3-N-acetylglucosaminyltransferase-3, beta1,3-N-acetylglucosaminyltransferase, beta1,3-N-acetylglucosaminyltransferase-7, beta1-3 N-acetylglucosaminyltransferase-1, beta3-N-acetylglucosaminyltransferase 1, beta3GlcNAcT, beta3Gn-T7, beta3GnT1, beta3GnT7, EC 2.4.1.163, Galbeta1-->4GlcNAc-R beta1-->3 N-acetylglucosaminyltransferase, GnT-I, i-GlcNAc transferase, i-GlcNAcT, IGnT, JHP1032, N-acetyllactosamine beta(1-3)N-acetylglucosaminyltransferase, poly-N-acetyllactosamine extension enzyme, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1, UDP-GlcNAc:Galbeta1-->4GlcNAcbeta-Rbeta1-->3-N-acetylglucosaminyltransferase, UDP-GlcNAc:Galbeta1-4Glc(NAc) beta-1,3-N-acetylglucosaminyltransferase, UDP-GlcNAc:GalR, beta-D-3-N-acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-acetyllactosaminide beta1-->3-acetylglucosaminyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.149 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase

Source Tissue

Source Tissue on EC 2.4.1.149 - N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
highly expressed in fetal and adult brain
Manually annotated by BRENDA team
very weak expression of beta3GnT7
Manually annotated by BRENDA team
-
Pro-5 and Lec2 CHO cells
Manually annotated by BRENDA team
beta3GnT7 is most strongly expressed in the placenta and colon
Manually annotated by BRENDA team
breast cancer cell line, higher expression of beta3GnT7 in cancer cell lines with low degrees of invasiveness
Manually annotated by BRENDA team
KLN205-MUC1, lung cancer cell line, higher expression of beta3GnT7 in cancer cell lines with low degrees of invasiveness
Manually annotated by BRENDA team
moderate expression of beta3GnT7
Manually annotated by BRENDA team
NSCLC, quantitative real-time PCR enzyme expression analysis
Manually annotated by BRENDA team
-
lymphoma cell line
Manually annotated by BRENDA team
-
pheochromacytoma cells, nerve growth factor stimulated cells with reduced GnT-i activity compared to unstimulated cells
Manually annotated by BRENDA team
-
new subline of pheochromacytoma cells PC-12, low GnT-i activity
Manually annotated by BRENDA team
moderate expression of beta3GnT7
Manually annotated by BRENDA team
colonic carcinoma cell line
Manually annotated by BRENDA team
-
colonic adenocarcinoma cell line
Manually annotated by BRENDA team
very weak expression of beta3GnT7
Manually annotated by BRENDA team
human melanoma cell line
Manually annotated by BRENDA team
additional information