2.4.1.141: N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase

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For detailed information about N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase, go to the full flat file.

Reaction

Synonyms

Alg 14, Alg13, Alg13p, Alg13p/Alg14p, Alg14, chitobiosyl-PP-lipid synthase, CLS, N,N'-diacetylchitobiosylpyrophosphoryldolichol synthase, UDP-GlcNAc transferase, UDP-GlcNAc:dolichyl-pyrophosphoryl-GlcNAc GlcNAc transferase, UDP-GlcNAc:GlcNAc-P-P-Dol N-acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-dolichylacetylglucosamine pyrophosphate acetylglucosaminyltransferase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.141 N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase

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Results	in table
5	Activating Compound
3026	AA Sequence
1	CAS Registry Number
2	Cloned(Commentary)
110	Disease/ Diagnostics
2	General Information
1	General Stability
1	IC50 Value
23	Inhibitors
2	Ki Value [mM]
6	KM Value [mM]
15	Localization
4	Metals/Ions
4	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
16	Organism
6	Pathway
2	PDB ID
3	pH Optimum
1	pH Range
3	Purification (Commentary)
1	Reaction
1	Reaction Type
15	Reference
9	Source Tissue
3	Storage Stability
13	Substrates and Products (Substrate)
5	Subunits
16	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]

General Stability

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General Stability on EC 2.4.1.141 - N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase

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GENERAL STABILITY

ORGANISM

UNIPROT

LITERATURE

cytosolic Alg13p is very short-lived, whereas membrane-associated Alg13 is relatively stable. Cytosolic Alg13p is a target for proteasomal degradation, and the failure to degrade excess Alg13p leads to glycosylation defects. Alg13p degradation requires a C-terminal domain whose deletion results in Alg13p stability. Appending this sequence onto normally long-lived beta-galactosidase causes it to undergo rapid degradation, demonstrating that this C-terminal domain represents a novel and autonomous degradation motif. Proteasomal degradation of excess unassembled Alg13p is an important quality control mechanism that ensures proper protein complex assembly and correct N-linked glycosylation

Saccharomyces cerevisiae

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688910