2.4.1.141: N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase
This is an abbreviated version!
For detailed information about N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase, go to the full flat file.
Reaction
Synonyms
Alg 14, Alg13, Alg13p, Alg13p/Alg14p, Alg14, chitobiosyl-PP-lipid synthase, CLS, N,N'-diacetylchitobiosylpyrophosphoryldolichol synthase, UDP-GlcNAc transferase, UDP-GlcNAc:dolichyl-pyrophosphoryl-GlcNAc GlcNAc transferase, UDP-GlcNAc:GlcNAc-P-P-Dol N-acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-dolichylacetylglucosamine pyrophosphate acetylglucosaminyltransferase
ECTree
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General Information
General Information on EC 2.4.1.141 - N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase
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metabolism
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during complex formation, Alg14 functions as a membrane anchor that recruits Alg13 to the cytosolic face of the endoplasmic reticulum as a result of interaction between their C-terminal regions. The N-terminal region of Alg14 is involved in mediating the interaction with Alg7
physiological function
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the Alg7p and Alg13p/Alg14p UDP-GlcNAc transferases together mediate the earliest steps of the N-linked glycosylation pathway