2.4.1.141: N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase

This is an abbreviated version!
For detailed information about N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase, go to the full flat file.

Reaction

Synonyms

Alg 14, Alg13, Alg13p, Alg13p/Alg14p, Alg14, chitobiosyl-PP-lipid synthase, CLS, N,N'-diacetylchitobiosylpyrophosphoryldolichol synthase, UDP-GlcNAc transferase, UDP-GlcNAc:dolichyl-pyrophosphoryl-GlcNAc GlcNAc transferase, UDP-GlcNAc:GlcNAc-P-P-Dol N-acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-dolichylacetylglucosamine pyrophosphate acetylglucosaminyltransferase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.141 N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase

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Results	in table
5	Activating Compound
3026	AA Sequence
1	CAS Registry Number
2	Cloned(Commentary)
110	Disease/ Diagnostics
2	General Information
1	General Stability
1	IC50 Value
23	Inhibitors
2	Ki Value [mM]
6	KM Value [mM]
15	Localization
4	Metals/Ions
4	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
16	Organism
6	Pathway
2	PDB ID
3	pH Optimum
1	pH Range
3	Purification (Commentary)
1	Reaction
1	Reaction Type
15	Reference
9	Source Tissue
3	Storage Stability
13	Substrates and Products (Substrate)
5	Subunits
16	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]

Substrates Products

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Substrates Products on EC 2.4.1.141 - N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

N-acetyl-D-glucosaminyl-diphosphodolichol + UDP-glucuronic acid

D-glucuronyl-1,4-N-acetyl-D-glucosaminyl-diphosphodolichol + UDP

3 entries

UDP-N-acetyl-alpha-D-glucosamine + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol

UDP + N,N'-diacetylchitobiosyl-diphosphodolichol

2 entries

UDP-N-acetyl-alpha-D-glucosamine + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol

UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol

5 entries

additional information

?

-

3 entries

N-acetyl-D-glucosaminyl-diphosphodolichol + UDP-glucuronic acid

D-glucuronyl-1,4-N-acetyl-D-glucosaminyl-diphosphodolichol + UDP

Rattus norvegicus

-

-

639511

-

639511

?

N-acetyl-D-glucosaminyl-diphosphodolichol + UDP-glucuronic acid

D-glucuronyl-1,4-N-acetyl-D-glucosaminyl-diphosphodolichol + UDP

Saccharomyces cerevisiae

-

-

674488

-

-

?

N-acetyl-D-glucosaminyl-diphosphodolichol + UDP-glucuronic acid

D-glucuronyl-1,4-N-acetyl-D-glucosaminyl-diphosphodolichol + UDP

Vigna radiata

-

-

639512

-

639512

?

UDP-N-acetyl-alpha-D-glucosamine + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol

UDP + N,N'-diacetylchitobiosyl-diphosphodolichol

Cricetulus griseus

-

-

639513, 685092

-

-

?

UDP-N-acetyl-alpha-D-glucosamine + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol

UDP + N,N'-diacetylchitobiosyl-diphosphodolichol

Mesocricetus auratus

-

-

703897

-

-

?

UDP-N-acetyl-alpha-D-glucosamine + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol

UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol

Gallus gallus

-

-

639514

-

-

?

UDP-N-acetyl-alpha-D-glucosamine + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol

UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol

Saccharomyces cerevisiae

-

-

722362

-

-

?

UDP-N-acetyl-alpha-D-glucosamine + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol

UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol

Saccharomyces cerevisiae

P38242, P53178

-

674482

-

-

?

UDP-N-acetyl-alpha-D-glucosamine + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol

UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol

Saccharomyces cerevisiae

P38242, P53178

second step in the biosynthesis of the unique lipid-linked core oligosaccharide

674482

-

-

?

UDP-N-acetyl-alpha-D-glucosamine + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol

UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol

Vigna radiata

-

-

639512

-

639512

?

additional information

?

-

Cricetulus griseus

-

5-fluoro N-acetylglucosamine is completely inactive as a glycosyl donor

685092

-

-

?

additional information

?

-

Saccharomyces cerevisiae

P53178

a short C-terminal alpha helix of Alg13 is required for interaction with Alg14 and for enzyme activity. The C-terminal three amino acids of Alg14 are required for maintaining the integrity of Alg13/Alg14 complex. They are involved in the stabilization of the interaction between the C-termini of Alg13 and Alg14. Deletion of the N-terminal alpha strand of Alg13 causes the destruction of protein, indicating the structural importance of this region in protein stability

687776

-

-

?

additional information

?

-

Saccharomyces cerevisiae

-

a short C-terminal alpha helix of Alg13 is required for interaction with Alg14 and for enzyme activity. The C-terminal three amino acids of Alg14 are required for maintaining the integrity of Alg13/Alg14 complex. They are involved in the stabilization of the interaction between the C-termini of Alg13 and Alg14. Deletion of the N-terminal alpha strand of Alg13 causes the destruction of protein, indicating the structural importance of this region in protein stability

687776

-

-

?