2.3.2.B12: ubiquitin transferase U-box E4

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For detailed information about ubiquitin transferase U-box E4, go to the full flat file.

Reaction

Synonyms

CHIP, CYC4, DUF1076 domain-containing protein, E4, E4 factor, E4 ligase, E4 ubiquitin ligase, E4 ubiquitin-protein ligase UFD2, MUSE3, PRP19, StoD, STY1076, Ub-conjugating E4 factor, Ube4A, UBE4B, ubiquitin chain elongation enzyme Ufd2, ubiquitin conjugation factor E4, ubiquitin fusion degradation protein 2, Ubr1-dependent E4 enzyme, UFD-2, Ufd2, Ufd2a, Ufd2b, Ufd4, Ufd4-enhancing ubiquitiylation enzyme

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.2 Aminoacyltransferases

                2.3.2.B12 ubiquitin transferase U-box E4

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Results	in table
7	AA Sequence
2	Application
4	Cloned(Commentary)
2	Crystallization (Commentary)
3	Disease/ Diagnostics
9	General Information
5	Localization
2	Natural Substrates/ Products (Substrates)
19	Organism
5	Protein Variants
1	Purification (Commentary)
3	Reaction
18	Reference
12	Source Tissue
20	Substrates and Products (Substrate)
35	Synonyms
1	Systematic Name

Natural Substrates Products

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Natural Substrates Products on EC 2.3.2.B12 - ubiquitin transferase U-box E4

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

additional information

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2 entries

additional information

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Saccharomyces cerevisiae

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the U-box domain is essentiel for the involvement of Ufd2 in Pex29 degradation. Pex29 is a peroxiisomal membrane protein that regulates the number and size of peroxisomes. Pex29 is regulated by ubiquitin-protein E3 ligase. Further extension of the growing ubiquitin chain requires assistance of Ufd2 due to the spatial positioning of the E3 and its substrate. Ufd2 elongates Pex29 with predominatly Lys48-linked ubiquitin chain in vivo

725391

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?

additional information

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Saccharomyces cerevisiae ATCC 204508

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the U-box domain is essentiel for the involvement of Ufd2 in Pex29 degradation. Pex29 is a peroxiisomal membrane protein that regulates the number and size of peroxisomes. Pex29 is regulated by ubiquitin-protein E3 ligase. Further extension of the growing ubiquitin chain requires assistance of Ufd2 due to the spatial positioning of the E3 and its substrate. Ufd2 elongates Pex29 with predominatly Lys48-linked ubiquitin chain in vivo

725391

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