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Literature summary for 2.3.2.B12 extracted from

  • Liu, C; van Dyk, D.; Xu, P.; Choe, V.; Pan, H.; Peng, J.; Andrews, B.; Rao, H.
    Ubiquitin chain elongation enzyme Ufd2 regulates a subset of Doa10 substrates (2010), J. Biol. Chem., 285, 10265-10272.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Saccharomyces cerevisiae the U-box domain is essentiel for the involvement of Ufd2 in Pex29 degradation. Pex29 is a peroxiisomal membrane protein that regulates the number and size of peroxisomes. Pex29 is regulated by ubiquitin-protein E3 ligase. Further extension of the growing ubiquitin chain requires assistance of Ufd2 due to the spatial positioning of the E3 and its substrate. Ufd2 elongates Pex29 with predominatly Lys48-linked ubiquitin chain in vivo ?
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?
additional information Saccharomyces cerevisiae ATCC 204508 the U-box domain is essentiel for the involvement of Ufd2 in Pex29 degradation. Pex29 is a peroxiisomal membrane protein that regulates the number and size of peroxisomes. Pex29 is regulated by ubiquitin-protein E3 ligase. Further extension of the growing ubiquitin chain requires assistance of Ufd2 due to the spatial positioning of the E3 and its substrate. Ufd2 elongates Pex29 with predominatly Lys48-linked ubiquitin chain in vivo ?
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?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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S288c, Y8835
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Saccharomyces cerevisiae ATCC 204508
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S288c, Y8835
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the U-box domain is essentiel for the involvement of Ufd2 in Pex29 degradation. Pex29 is a peroxiisomal membrane protein that regulates the number and size of peroxisomes. Pex29 is regulated by ubiquitin-protein E3 ligase. Further extension of the growing ubiquitin chain requires assistance of Ufd2 due to the spatial positioning of the E3 and its substrate. Ufd2 elongates Pex29 with predominatly Lys48-linked ubiquitin chain in vivo Saccharomyces cerevisiae ?
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?
additional information one target of Ufd2 is identified as Pex29, the ubiquitin-protein conjugate ubiquitinylated by the ubiquitin-protein E3 ligase Doa10. Not all Doa10 substrates are regulated by Ufd2, suggesting that E4 involvement is not specific to a particular E3, but might depend on the spatial arrangement of the E3-substrate interaction Saccharomyces cerevisiae ?
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?
additional information the U-box domain is essentiel for the involvement of Ufd2 in Pex29 degradation. Pex29 is a peroxiisomal membrane protein that regulates the number and size of peroxisomes. Pex29 is regulated by ubiquitin-protein E3 ligase. Further extension of the growing ubiquitin chain requires assistance of Ufd2 due to the spatial positioning of the E3 and its substrate. Ufd2 elongates Pex29 with predominatly Lys48-linked ubiquitin chain in vivo Saccharomyces cerevisiae ATCC 204508 ?
-
?
additional information one target of Ufd2 is identified as Pex29, the ubiquitin-protein conjugate ubiquitinylated by the ubiquitin-protein E3 ligase Doa10. Not all Doa10 substrates are regulated by Ufd2, suggesting that E4 involvement is not specific to a particular E3, but might depend on the spatial arrangement of the E3-substrate interaction Saccharomyces cerevisiae ATCC 204508 ?
-
?

Synonyms

Synonyms Comment Organism
ubiquitin chain elongation enzyme Ufd2
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Saccharomyces cerevisiae
Ufd2 founding member of the E4 enzymes, belongs to a family containing a conserved U-box motif Saccharomyces cerevisiae