Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Saccharomyces cerevisiae | the U-box domain is essentiel for the involvement of Ufd2 in Pex29 degradation. Pex29 is a peroxiisomal membrane protein that regulates the number and size of peroxisomes. Pex29 is regulated by ubiquitin-protein E3 ligase. Further extension of the growing ubiquitin chain requires assistance of Ufd2 due to the spatial positioning of the E3 and its substrate. Ufd2 elongates Pex29 with predominatly Lys48-linked ubiquitin chain in vivo | ? | - |
? | |
additional information | Saccharomyces cerevisiae ATCC 204508 | the U-box domain is essentiel for the involvement of Ufd2 in Pex29 degradation. Pex29 is a peroxiisomal membrane protein that regulates the number and size of peroxisomes. Pex29 is regulated by ubiquitin-protein E3 ligase. Further extension of the growing ubiquitin chain requires assistance of Ufd2 due to the spatial positioning of the E3 and its substrate. Ufd2 elongates Pex29 with predominatly Lys48-linked ubiquitin chain in vivo | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
S288c, Y8835 | - |
Saccharomyces cerevisiae ATCC 204508 | - |
S288c, Y8835 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the U-box domain is essentiel for the involvement of Ufd2 in Pex29 degradation. Pex29 is a peroxiisomal membrane protein that regulates the number and size of peroxisomes. Pex29 is regulated by ubiquitin-protein E3 ligase. Further extension of the growing ubiquitin chain requires assistance of Ufd2 due to the spatial positioning of the E3 and its substrate. Ufd2 elongates Pex29 with predominatly Lys48-linked ubiquitin chain in vivo | Saccharomyces cerevisiae | ? | - |
? | |
additional information | one target of Ufd2 is identified as Pex29, the ubiquitin-protein conjugate ubiquitinylated by the ubiquitin-protein E3 ligase Doa10. Not all Doa10 substrates are regulated by Ufd2, suggesting that E4 involvement is not specific to a particular E3, but might depend on the spatial arrangement of the E3-substrate interaction | Saccharomyces cerevisiae | ? | - |
? | |
additional information | the U-box domain is essentiel for the involvement of Ufd2 in Pex29 degradation. Pex29 is a peroxiisomal membrane protein that regulates the number and size of peroxisomes. Pex29 is regulated by ubiquitin-protein E3 ligase. Further extension of the growing ubiquitin chain requires assistance of Ufd2 due to the spatial positioning of the E3 and its substrate. Ufd2 elongates Pex29 with predominatly Lys48-linked ubiquitin chain in vivo | Saccharomyces cerevisiae ATCC 204508 | ? | - |
? | |
additional information | one target of Ufd2 is identified as Pex29, the ubiquitin-protein conjugate ubiquitinylated by the ubiquitin-protein E3 ligase Doa10. Not all Doa10 substrates are regulated by Ufd2, suggesting that E4 involvement is not specific to a particular E3, but might depend on the spatial arrangement of the E3-substrate interaction | Saccharomyces cerevisiae ATCC 204508 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ubiquitin chain elongation enzyme Ufd2 | - |
Saccharomyces cerevisiae |
Ufd2 | founding member of the E4 enzymes, belongs to a family containing a conserved U-box motif | Saccharomyces cerevisiae |