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2.3.1.85: fatty-acid synthase system

This is an abbreviated version!
For detailed information about fatty-acid synthase system, go to the full flat file.

Word Map on EC 2.3.1.85

Reaction

acetyl-CoA
+ 7 malonyl-CoA + 14 NADPH + 14 H+ =
hexadecanoate
 + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O

Synonyms

F09E10.3 protein, FAS, FAS-II, FASI, FASII, FASN, fatty acid synthase, fatty acid synthase I, fatty acid synthase II, fatty acid synthase type 2, fatty-acid synthase, type 2 dissociative FAS, type 2 fatty acid synthase, type II fatty acid synthase, yeast fatty acid synthase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.85 fatty-acid synthase system

Purification

Purification on EC 2.3.1.85 - fatty-acid synthase system

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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
2 beta-ketoacyl reductase containing fragments after sequential proteolysis
-
680fold, erythrocyte enzyme immunologically not related to liver enzyme
-
95% pure, transacyclase domain
-
domain I with acetyl and malonyl transacetylase activity and beta-hydroxyacyl dehydratase activity after expression in E. coli
-
fusion protein with maltose-binding protein
-
homogeneity
isolation of modified dimers containing independently mutated subunits
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near homogeneity
-
partial
-
purification of 2 structurally related but functionally differentiated fatty acid synthases: FAS-A and FAS-B, homogeneity
-