Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,3-Dibromo-2-propanone | acetyl-CoA, not malonyl-CoA, protects against inactivation, both protect against cross-linking of the subunits | Oryctolagus cuniculus | |
chloroacetyl-CoA | - |
Oryctolagus cuniculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
additional information | - |
molecular weight of fragments after proteolytic cleavage | Oryctolagus cuniculus |
250000 | - |
2 * 250000, SDS-PAGE | Oryctolagus cuniculus |
Organic Solvent | Comment | Organism |
---|---|---|
acetonitrile | up to 10% v/v, stable to | Oryctolagus cuniculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
female | - |
Purification (Comment) | Organism |
---|---|
- |
Oryctolagus cuniculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mammary gland | lactating | Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ | - |
Oryctolagus cuniculus | palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 250000, SDS-PAGE | Oryctolagus cuniculus |
More | alpha2-dimer of multifunctional subunits: each subunit contains up to seven active centres required for palmitate synthesis | Oryctolagus cuniculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
4'-phosphopantetheine | location of active site | Oryctolagus cuniculus | |
4'-phosphopantetheine | present in substoichiometric amounts | Oryctolagus cuniculus |