2.3.1.85: fatty-acid synthase system

This is an abbreviated version!
For detailed information about fatty-acid synthase system, go to the full flat file.

Word Map on EC 2.3.1.85

2.3.1.85

mycobacterium

tuberculosis

mycolic

lipogenic

enoyl

fasciclin

cerulenin

beta-ketoacyl-acyl

malonyl-coa

triclosan

isoniazid

transacylase

enoyl-acyl

beta-ketoacyl

thiolactomycin

malonyl-acp

condensing

acyl-acps

malonyl

srebp-1c

fabgs

medicine

apicoplast

boutons

phosphopantetheinylation

4'-phosphopantetheine

ketoacyl

antituberculous

thiacetazone

nutrition

analysis

Reaction

+ 7 malonyl-CoA + 14 NADPH + 14 H+ =

+ 8 CoA + 7 CO2 + 14 NADP⁺ + 6 H2O

Synonyms

F09E10.3 protein, FAS, FAS-II, FASI, FASII, FASN, fatty acid synthase, fatty acid synthase I, fatty acid synthase II, fatty acid synthase type 2, fatty-acid synthase, type 2 dissociative FAS, type 2 fatty acid synthase, type II fatty acid synthase, yeast fatty acid synthase

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.85 fatty-acid synthase system

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Results	in table
1578	AA Sequence
14	Application
1	CAS Registry Number
14	Cloned(Commentary)
57	Cofactor
7	Crystallization (Commentary)
200	Disease/ Diagnostics
13	Expression
6	General Information
13	General Stability
34	IC50 Value
164	Inhibitors
12	kcat/KM [mM/s]
19	Ki Value [mM]
45	KM Value [mM]
10	Localization
26	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
276	Organism
4	Pathway
43	PDB ID
4	pH Optimum
1	pH Stability
1	Posttranslational Modification
41	Protein Variants
24	Purification (Commentary)
29	Reaction
4	Reaction Type
114	Reference
2	Renatured (Commentary)
110	Source Tissue
27	Specific Activity [micromol/min/mg]
12	Storage Stability
75	Substrates and Products (Substrate)
25	Subunits
39	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
1	Temperature Stability [°C]
32	Turnover Number [1/s]

Specific Activity

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Specific Activity on EC 2.3.1.85 - fatty-acid synthase system

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0.015

Rattus norvegicus

for malonyl-CoA, R606A mutant

0.078 - 0.1

palmitate

0.14 - 0.16

0.154

for malonyl-CoA, R606K mutant

486873

0.31

Corynebacterium ammoniagenes

FAS-A

487590

0.37

Corynebacterium ammoniagenes

FAS-B

0.6

NADPH

1.12 - 1.4

NADPH, 30°C

1.13 - 2.77

various tagged wild-type enzyme

1.2

NADPH

1.2 - 1.6

NADPH

1.3

NADPH

1.61

for malonyl-CoA, wild-type enzyme

486873

17.8

Rattus norvegicus

for acetyl-CoA, R606A mutant

486873

2.049

Rattus norvegicus

wild-type enzyme, activity in mutants is less than 0.5%

2.6

NADPH

2.68

for acetyl-CoA, wild-type enzyme

486873

4.53

Rattus norvegicus

for acetyl-CoA, R606K mutant

486873

additional information

8 entries