2.3.1.67: 1-alkylglycerophosphocholine O-acetyltransferase

This is an abbreviated version!
For detailed information about 1-alkylglycerophosphocholine O-acetyltransferase, go to the full flat file.

Reaction

Synonyms

1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase, acetyl-CoA: lyso-PAF acetyltransferase, acetyl-CoA:1-alkyl-2-lyso-sn-glycero-3-phosphocholine 2-O-acetyltransferase, acetyl-CoA:1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase, acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase, acetyl-CoA:lyso-PAF acetyltransferase, acetyl-CoA:lysoPAF acetyltransferase, acetyl-coenzyme A:1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase, acetyl-coenzymeA:lysoPAF acetyltransferase, acetyltransferase, 1-alkyl-2-lysolecithin, acetyltransferase, 1-alkylglycerophosphocholine, acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acyltransferase, blood platelet-activating factor acetyltransferase, lpafat1, LPCAT1, LPCAT2, lyso-GPC:acetyl CoA acetyltransferase, lyso-PAF acetyltransferase, lyso-PAF acetyltransferase:LPC acyltransferase 1, lyso-PAF AT, Lyso-PAF ATC, Lyso-PAF ATE, lyso-PAF-acetyltransferase, lyso-PAF-AcT, Lyso-PAF-AT, lyso-PAF:acetyl-CoA acetyltransferase, lyso-PAFAT, lyso-platelet activating factor:acetyl-CoA acetyltransferase, lyso-platelet-activating factor acetyltransferase, lyso-platelet-activating factor:acetyl-CoA acetyltransferase, lysoPAF-AT, lysoPAF:acetyl CoA acetyltransferase, lysoPAFAT, lysophosphatidylcholine acyltransferase (LPCAT2)/lyso-PAF acetyltransferase, lysophosphatidylcholine acyltransferase 1, mLysoPAFAT/LPCAT2, PAF acetyltransferase, platelet-activating factor acylhydrolase, platelet-activating factor-synthesizing enzyme

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.67 1-alkylglycerophosphocholine O-acetyltransferase

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Results	in table
18	Activating Compound
37	AA Sequence
8	Application
1	CAS Registry Number
8	Cloned(Commentary)
7	Cofactor
3	Disease/ Diagnostics
8	Expression
13	General Information
4	General Stability
63	IC50 Value
141	Inhibitors
17	KM Value [mM]
21	Localization
6	Metals/Ions
3	Molecular Weight [Da]
19	Natural Substrates/ Products (Substrates)
51	Organism
2	Pathway
29	pH Optimum
2	pH Range
2	Posttranslational Modification
10	Protein Variants
4	Purification (Commentary)
1	Reaction
5	Reaction Type
48	Reference
63	Source Tissue
24	Specific Activity [micromol/min/mg]
80	Substrates and Products (Substrate)
1	Subunits
76	Synonyms
1	Systematic Name
24	Temperature Optimum [°C]
1	Temperature Stability [°C]

IC50 Value

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IC50 Value on EC 2.3.1.67 - 1-alkylglycerophosphocholine O-acetyltransferase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.072

(-)-epicatechin-3-O-gallate

Oryctolagus cuniculus

-

IC50: 0.072 mM

658920

0.073

(-)-epigallocatechin

Oryctolagus cuniculus

-

IC50: 0.073 mM

658920

0.046

(-)-epigallocatechin-3-O-gallate

Oryctolagus cuniculus

-

IC50: 0.046 mM

658920

0.029

(4,4',5,5',6,6'-hexahydroxybiphenyl-2,2'-diyl)bis[(2R,3R)-5,7-dihydroxy-3,4-dihydro-2H-chromene-2,3-diyl] bis(3,4,5-trihydroxybenzoate)

Oryctolagus cuniculus

-

IC50: 0.029 mM

658920

0.026

1,2,3,4,6-pentagalloyl-beta-D-glucose

Oryctolagus cuniculus

-

IC50: 0.026 mM

658920

0.5

1,4-diacetoxy-2-methoxy-5-methyl-3-tetradecanoyloxybenzene

Mus musculus

Q8BYI6

pH 6.9, 37°C

735644

0.048

1-methoxyphaseolidin

Rattus norvegicus

-

IC50: 0.048 mM

487389

0.057

1-methoxyphaseolin

Rattus norvegicus

-

IC50: 0.057 mM

487389

0.101

2-methoxy-1,3,4-trihydroxy-5-methylbenzene

Mus musculus

Q8BYI6

pH 6.9, 37°C

735644

0.5

2-methoxy-5-methyl-1,3,4-triacetoxybenzene

Mus musculus

Q8BYI6

pH 6.9, 37°C

735644

0.391

2-methoxy-5-methyl-3-octadecanoyloxy-1,4-benzoquinone

Mus musculus

Q8BYI6

pH 6.9, 37°C

735644

0.02

2-methoxy-5-methyl-3-tetradecanoyloxy-1,4-benzoquinone

2 entries

0.0171

3,4-dichloro-1-(4,5-dichloro-2-methoxyphenyl)-1H-pyrrole-2,5-dione

Homo sapiens

Q7L5N7

pH 7.4, 37°C

736604

0.166

3,4-dihydroxy-1,2-dimethoxy-5-methylbenzene

Mus musculus

Q8BYI6

pH 6.9, 37°C

735644

0.121

3-acetoxy-2-methoxy-5-methyl-1,4-benzoquinone

Mus musculus

Q8BYI6

pH 6.9, 37°C

735644

0.00758

3-chloro-1-(3-chloro-4-methoxyphenyl)-4-(2-methoxyphenoxy)-1H-pyrrole-2,5-dione

Homo sapiens

Q7L5N7

pH 7.4, 37°C

736604

0.02

3-chloro-1-(4,5-dichloro-2-methoxyphenyl)-4-(2-hydroxyanilino)-1H-pyrrole-2,5-dione

Homo sapiens

Q7L5N7

pH 7.4, 37°C

736604

0.00116

3-chloro-4-(morpholin-4-yl)-1-(4-phenoxyphenyl)-1H-pyrrole-2,5-dione

Homo sapiens

Q7L5N7

pH 7.4, 37°C

736604

0.003

3-decanoyloxy-2-methoxy-5-methyl-1,4-benzoquinone

2 entries

0.139

3-hexanoyloxy-2-methoxy-5-methyl-1,4-benzoquinone

Mus musculus

Q8BYI6

pH 6.9, 37°C

735644

0.109

3-hydroxy-2-methoxy-5-methyl-1,4-benzoquinone

Mus musculus

Q8BYI6

pH 6.9, 37°C

735644

0.043

4-(1-Naphthylvinyl)pyridine

Rattus norvegicus

-

IC50: 0.043 mM

487388

0.019

6,8-diprenylgenistein

Rattus norvegicus

-

IC50: 0.019 mM

487389

1.52

acetyl-salicylic acid

Bos taurus

-

IC50: 1.52 mM

487390

0.105 - 0.148

baicalein

2 entries

0.00033

butyl 4-(3,4-dichloro-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoate

Homo sapiens

Q7L5N7

pH 7.4, 37°C

736604

0.2

chiyusaponin

Rattus norvegicus

-

IC50: 0.2 mM

487385

0.5

Decanoic acid

Mus musculus

Q8BYI6

pH 6.9, 37°C

735644

0.419

dodecanoic acid

Mus musculus

Q8BYI6

pH 6.9, 37°C

735644

0.066

farnesyl gallate

Oryctolagus cuniculus

-

IC50: 0.066 mM

658920

0.089

geranyl gallate

Oryctolagus cuniculus

-

IC50: 0.089 mM

658920

0.06 - 0.15

honokiol

2 entries

0.26

indomethacin

Bos taurus

-

IC50: 0.26 mM

487390

0.0077

licoricidin

Rattus norvegicus

-

IC50: 0.0077 mM

487389

0.045

luteolin

Rattus norvegicus

-

IC50: 0.045 mM

487388

0.07 - 0.15

magnolol

2 entries

0.0116

methyl 4-(3,4-dichloro-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoate

Homo sapiens

Q7L5N7

pH 7.4, 37°C

736604

0.02

methyl 4-[3-chloro-2,5-dioxo-4-(4-sulfamoylanilino)-2,5-dihydro-1H-pyrrol-1-yl]benzoate

Homo sapiens

Q7L5N7

pH 7.4, 37°C

736604

0.183

myristic acid

Mus musculus

Q8BYI6

pH 6.9, 37°C

735644

0.091

n-dodecyl gallate

Oryctolagus cuniculus

-

IC50: 0.091 mM

658920

0.06 - 0.29

nordihydroguaiaretic acid

3 entries

0.5

octanoic acid

Mus musculus

Q8BYI6

pH 6.9, 37°C

735644

0.5

palmitic acid

Mus musculus

Q8BYI6

pH 6.9, 37°C

735644

0.031

procyanidin B-2,3,3'-di-O-gallate

Oryctolagus cuniculus

-

IC50: 0.031 mM

658920

0.024

procyanidin B-5,3,3'-di-O-gallate

Oryctolagus cuniculus

-

IC50: 0.024 mM

658920

0.00127

propan-2-yl 4-(3,4-dichloro-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoate

Homo sapiens

Q7L5N7

pH 7.4, 37°C

736604

0.00047

propan-2-yl 4-(3-chloro-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoate

Homo sapiens

Q7L5N7

pH 7.4, 37°C

736604

0.0133

propan-2-yl 4-[3-chloro-4-(2-hydroxyanilino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl]benzoate

Homo sapiens

Q7L5N7

pH 7.4, 37°C

736604

0.02

propan-2-yl 4-[3-chloro-4-(morpholin-4-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl]benzoate

Homo sapiens

Q7L5N7

pH 7.4, 37°C

736604

0.0003

propyl 4-(3,4-dichloro-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoate

Homo sapiens

Q7L5N7

pH 7.4, 37°C

736604

0.08

quercetin

Rattus norvegicus

-

IC50: 0.08 mM

487388

0.183

tetradecanoic acid

Rattus norvegicus

-

pH 6.9, 37°C

735644

0.032

theaflavin

Oryctolagus cuniculus

-

IC50: 0.032 mM

658920

0.039

theaflavin-3'-O-gallate

Oryctolagus cuniculus

-

IC50: 0.039 mM

658920

0.028

theaflavin-3,3'-di-O-gallate

Oryctolagus cuniculus

-

IC50: 0.028 mM

658920

0.058

theaflavin-3-O-gallate

Oryctolagus cuniculus

-

IC50: 0.058 mM

658920

0.02

2-methoxy-5-methyl-3-tetradecanoyloxy-1,4-benzoquinone

Rattus norvegicus

-

pH 6.9, 37°C

735644

0.02

2-methoxy-5-methyl-3-tetradecanoyloxy-1,4-benzoquinone

Mus musculus

Q8BYI6

pH 6.9, 37°C

735644

0.003

3-decanoyloxy-2-methoxy-5-methyl-1,4-benzoquinone

Rattus norvegicus

-

pH 6.9, 37°C

735644

0.003

3-decanoyloxy-2-methoxy-5-methyl-1,4-benzoquinone

Mus musculus

Q8BYI6

pH 6.9, 37°C

735644

0.105

baicalein

Bos taurus

-

concentration dependent inhibition, IC50: 0.105 mM

487390

0.148

baicalein

Rattus norvegicus

-

IC50: 0.148 mM

487385

0.06

honokiol

Homo sapiens

-

IC50: 0.06 mM, reversible inhibition

487385

0.15

honokiol

Rattus norvegicus

-

IC50: 0.15 mM

487385

0.07

magnolol

Homo sapiens

-

IC50: 0.07 mM, reversible inhibition

487385

0.15

magnolol

Rattus norvegicus

-

IC50: 0.15 mM

487385

0.06

nordihydroguaiaretic acid

Homo sapiens

-

IC50: 0.06 mM

487385

0.075

nordihydroguaiaretic acid

Bos taurus

-

concentration dependent inhibition, IC50: 0.075 mM

487390

0.29

nordihydroguaiaretic acid

Rattus norvegicus

-

IC50: 0.29 mM

487385