2.3.1.67: 1-alkylglycerophosphocholine O-acetyltransferase
This is an abbreviated version!
For detailed information about 1-alkylglycerophosphocholine O-acetyltransferase, go to the full flat file.
Word Map on EC 2.3.1.67
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2.3.1.67
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paf-ah
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acetylhydrolase
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paf-cpt
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cholinephosphotransferase
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1-o-alkyl-2-acetyl-sn-glycero-3-phosphocholine
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paf-acetylhydrolase
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coa-independent
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transacylase
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dtt-insensitive
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3hacetate
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paf-synthesizing
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1-o-alkyl-sn-glycero-3-phosphocholine
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14carachidonic
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phospholipase-a2
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medicine
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lppla2
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analysis
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drug development
- 2.3.1.67
- paf-ah
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acetylhydrolase
- paf-cpt
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cholinephosphotransferase
- 1-o-alkyl-2-acetyl-sn-glycero-3-phosphocholine
- paf-acetylhydrolase
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coa-independent
-
transacylase
-
dtt-insensitive
-
3hacetate
-
paf-synthesizing
- 1-o-alkyl-sn-glycero-3-phosphocholine
-
14carachidonic
-
phospholipase-a2
- medicine
- lppla2
- analysis
- drug development
Reaction
Synonyms
1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase, acetyl-CoA: lyso-PAF acetyltransferase, acetyl-CoA:1-alkyl-2-lyso-sn-glycero-3-phosphocholine 2-O-acetyltransferase, acetyl-CoA:1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase, acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase, acetyl-CoA:lyso-PAF acetyltransferase, acetyl-CoA:lysoPAF acetyltransferase, acetyl-coenzyme A:1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase, acetyl-coenzymeA:lysoPAF acetyltransferase, acetyltransferase, 1-alkyl-2-lysolecithin, acetyltransferase, 1-alkylglycerophosphocholine, acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acyltransferase, blood platelet-activating factor acetyltransferase, lpafat1, LPCAT1, LPCAT2, lyso-GPC:acetyl CoA acetyltransferase, lyso-PAF acetyltransferase, lyso-PAF acetyltransferase:LPC acyltransferase 1, lyso-PAF AT, Lyso-PAF ATC, Lyso-PAF ATE, lyso-PAF-acetyltransferase, lyso-PAF-AcT, Lyso-PAF-AT, lyso-PAF:acetyl-CoA acetyltransferase, lyso-PAFAT, lyso-platelet activating factor:acetyl-CoA acetyltransferase, lyso-platelet-activating factor acetyltransferase, lyso-platelet-activating factor:acetyl-CoA acetyltransferase, lysoPAF-AT, lysoPAF:acetyl CoA acetyltransferase, lysoPAFAT, lysophosphatidylcholine acyltransferase (LPCAT2)/lyso-PAF acetyltransferase, lysophosphatidylcholine acyltransferase 1, mLysoPAFAT/LPCAT2, PAF acetyltransferase, platelet-activating factor acylhydrolase, platelet-activating factor-synthesizing enzyme
ECTree
2.3.1.67 1-alkylglycerophosphocholine O-acetyltransferaseAdvanced search results
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results (Activating Compound
Activating Compound on EC 2.3.1.67 - 1-alkylglycerophosphocholine O-acetyltransferase
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ACTIVATING COMPOUND 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
bovine serum albumin
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optimal concentration of 1-1.5 mg/ml at short incubation periods and 2-2.5 mg bovine serum albumin/ml during longer incubation periods
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H2O2
increased in concentration-dependent manner, fast but transitory activation, concentrations of H2O2 ranging from 1 to 10 mM, maximal effect at 10 mM, maximum reached within 20 min
interleukin 1beta
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2.5 ng/ml, induces 2fold increase in intracellular platelet activating factor levels against non-stimulated cells, as well as in the specific activity of acetyl-CoA:lyso-PAF acetyltransferase at 3 h. Effect is inhibited in presence of tyrosol or resveratrol
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lipopolysaccharide
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activity increases in a time-dependent fashion, maximal activation at 0.010 mg/ml lipopolysaccharide
N-formyl-methionyl-leucyl-phenylalanine
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stimulation is dependent on the preincubation of cells with cytochalasin B, addition of tumor necrosis factor increases 50% alkyl-2-acetyl-sn-glycero-3-phosphocholine production
AMP-dependent protein kinase
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activity increases 2-3fold in presence of MgATP2-, activation is reversible, stimulation is optimal with 30 U/ml protein kinase
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additional information
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membrane-permeable oxidants more effective to provoke synthesis of platelet-activating factor (PAF), no effect on synthesis of platelet-activating factor (PAF) observed in cells treated with 10 mM 2,2'-azobis(2-amidinopropane) dihydrochloride or with 5 mM hydrophobic cumen hydroperoxide
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additional information
membrane-permeable oxidants more effective to provoke synthesis of platelet-activating factor (PAF), no effect on synthesis of platelet-activating factor (PAF) observed in cells treated with 10 mM 2,2'-azobis(2-amidinopropane) dihydrochloride or with 5 mM hydrophobic cumen hydroperoxide
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additional information
500 ml/day of low-fat milk fortified with phytosterols, linoleic and alpha linolenic acids, vitamin C, vitamin E, vitamin A, vitamin B6, vitamin B12, folic acid, magnesium and selenium has no effect on the enzyme activity in vivo
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additional information
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the enzyme is activated 1. by a second-order time course after stimulation with platelet-activating factor receptor, 2. by a minute-order time course after LPS stimulation in the MyD88-dependent and p38 MAPK-dependent pathway, and 3. by an hour-order time course after LPS-stimulation in the MyD88-independent and TRIF-independent pathway
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additional information
the enzyme is rapidly phosphorylated after methylcarbamylplatelet-activating factor stimulation to enhance its enzymatic activity. Knockdown of PKCalpha results in significant decrease of lyso-PAFAT activation after ATP stimulation
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additional information
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the enzyme is rapidly phosphorylated after methylcarbamylplatelet-activating factor stimulation to enhance its enzymatic activity. Knockdown of PKCalpha results in significant decrease of lyso-PAFAT activation after ATP stimulation
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