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2.3.1.67: 1-alkylglycerophosphocholine O-acetyltransferase

This is an abbreviated version!
For detailed information about 1-alkylglycerophosphocholine O-acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.67

Reaction

acetyl-CoA
+
1-alkyl-sn-glycero-3-phosphocholine
=
CoA
 +
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine

Synonyms

1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase, acetyl-CoA: lyso-PAF acetyltransferase, acetyl-CoA:1-alkyl-2-lyso-sn-glycero-3-phosphocholine 2-O-acetyltransferase, acetyl-CoA:1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase, acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase, acetyl-CoA:lyso-PAF acetyltransferase, acetyl-CoA:lysoPAF acetyltransferase, acetyl-coenzyme A:1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase, acetyl-coenzymeA:lysoPAF acetyltransferase, acetyltransferase, 1-alkyl-2-lysolecithin, acetyltransferase, 1-alkylglycerophosphocholine, acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acyltransferase, blood platelet-activating factor acetyltransferase, lpafat1, LPCAT1, LPCAT2, lyso-GPC:acetyl CoA acetyltransferase, lyso-PAF acetyltransferase, lyso-PAF acetyltransferase:LPC acyltransferase 1, lyso-PAF AT, Lyso-PAF ATC, Lyso-PAF ATE, lyso-PAF-acetyltransferase, lyso-PAF-AcT, Lyso-PAF-AT, lyso-PAF:acetyl-CoA acetyltransferase, lyso-PAFAT, lyso-platelet activating factor:acetyl-CoA acetyltransferase, lyso-platelet-activating factor acetyltransferase, lyso-platelet-activating factor:acetyl-CoA acetyltransferase, lysoPAF-AT, lysoPAF:acetyl CoA acetyltransferase, lysoPAFAT, lysophosphatidylcholine acyltransferase (LPCAT2)/lyso-PAF acetyltransferase, lysophosphatidylcholine acyltransferase 1, mLysoPAFAT/LPCAT2, PAF acetyltransferase, platelet-activating factor acylhydrolase, platelet-activating factor-synthesizing enzyme

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.67 1-alkylglycerophosphocholine O-acetyltransferase

Inhibitors

Inhibitors on EC 2.3.1.67 - 1-alkylglycerophosphocholine O-acetyltransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(-)-epicatechin-3-O-gallate
-
IC50: 0.072 mM
(-)-epigallocatechin
-
IC50: 0.073 mM
(-)-epigallocatechin-3-O-gallate
-
IC50: 0.046 mM
(4,4',5,5',6,6'-hexahydroxybiphenyl-2,2'-diyl)bis[(2R,3R)-5,7-dihydroxy-3,4-dihydro-2H-chromene-2,3-diyl] bis(3,4,5-trihydroxybenzoate)
-
-
1,2,3,4,6-pentagalloyl-beta-D-glucose
-
IC50: 0.026 mM
1,4-diacetoxy-2-methoxy-5-methyl-3-tetradecanoyloxybenzene
-
1-acyl-sn-glycero-3-phosphate
-
competitive inhibition for 1-alkyl-sn-glycero-3-phosphate
1-methoxyphaseolidin
-
IC50: 0.048 mM
1-methoxyphaseolin
-
IC50: 0.057 mM
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine
-
irreversible inhibition dependent of both 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine and enzyme concentration
1-O-alkyl-sn-glycero-3-phosphocholine
-
inhibition at high concentrations due to its detergent effect
2-mercaptoethanol
-
-
2-methoxy-1,3,4-trihydroxy-5-methylbenzene
i.e. 2-methoxy-1,3,4-trihydroxy-5-methylbenzene, isolated from Penicillium sp. strain F33
2-methoxy-5-methyl-1,3,4-triacetoxybenzene
-
2-methoxy-5-methyl-3-octadecanoyloxy-1,4-benzoquinone
-
2-methoxy-5-methyl-3-tetradecanoyloxy-1,4-benzoquinone
3,4-dichloro-1-(4,5-dichloro-2-methoxyphenyl)-1H-pyrrole-2,5-dione
3,4-dihydroxy-1,2-dimethoxy-5-methylbenzene
-
3-acetoxy-2-methoxy-5-methyl-1,4-benzoquinone
-
3-chloro-1-(3-chloro-4-methoxyphenyl)-4-(2-methoxyphenoxy)-1H-pyrrole-2,5-dione
3-chloro-1-(4,5-dichloro-2-methoxyphenyl)-4-(2-hydroxyanilino)-1H-pyrrole-2,5-dione
3-chloro-4-(morpholin-4-yl)-1-(4-phenoxyphenyl)-1H-pyrrole-2,5-dione
3-decanoyloxy-2-methoxy-5-methyl-1,4-benzoquinone
3-hexanoyloxy-2-methoxy-5-methyl-1,4-benzoquinone
-
3-hydroxy-2-methoxy-5-methyl-1,4-benzoquinone
-
4-(1-Naphthylvinyl)pyridine
-
IC50: 0.043 mM
6,8-diprenylgenistein
-
IC50: 0.019 mM
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
i.e. Trolox, reduces production of platelet-activating factor (PAF) in H2O2-treated HUVEC cells
acetyl-salicylic acid
Arachidonoyl-CoA
-
-
ascorbic acid
-
18.3% inhibition at 1 mM
baicalein
butyl 4-(3,4-dichloro-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoate
CaCl2
chiyusaponin
-
IC50: 0.2 mM
Decanoic acid
-
dexamethasone
-
2 mg/kg for 3 days in liver and spleen
dihydrofumigatin
i.e. 2-methoxy-1,3,4-trihydroxy-5-methylbenzene, isolated from Penicillium sp. strain F33
diisopropylfluorophosphate
dithiothreitol
-
-
dodecanoic acid
-
ebselen
-
suppresses alkyl-2-acetyl-sn-glycero-3-phosphocholine synthesis by 7.7% and 26.6% in presence of glutathione
farnesyl gallate
-
IC50: 0.066 mM
gallic acid
-
5.3% inhibition at 0.1 mM
geranyl gallate
-
IC50: 0.089 mM
glutathione
-
suppresses alkyl-2-acetyl-sn-glycero-3-phosphocholine synthesis by 18.9%
H2O2
-
8% inhibition at 1 mM
honokiol
indomethacin
licoricidin
-
IC50: 0.0077 mM
lopinavir-r
-
remaining activity in human mesangial cells: 76%. By contrast no effect on activity is observed in blood of naiive patients treated with the drug
luteolin
-
IC50: 0.045 mM
lysophosphatidylcholine
-
inhibition at high concentrations due to its detergent effect
magnolol
medroxyprogesterone
-
50 mg/kg in liver
methyl 4-(3,4-dichloro-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoate
methyl 4-[3-chloro-2,5-dioxo-4-(4-sulfamoylanilino)-2,5-dihydro-1H-pyrrol-1-yl]benzoate
MgATP2-
-
32% and 54% inhibition at 0.125 and 1 mM respectively in neuronal nuclear fraction
MgCl2
MnCl2
myricetin
-
suppresses alkyl-2-acetyl-sn-glycero-3-phosphocholine synthesis by 17%
myristic acid
-
N-acetylcysteine
reduces production of platelet-activating factor (PAF) in H2O2-treated HUVEC cells
n-dodecyl gallate
-
IC50: 0.091 mM
N-ethylmaleimide
-
-
nordihydroguaiaretic acid
octanoic acid
-
oleic acid
-
1-acyl lysolipids less inhibited than the 1-alkyl species
oleoyl-CoA
p-bromophenacyl bromide
p-chloromercuribenzoate
-
-
palmitic acid
-
palmitoyl-CoA
palmitoyllyso-glycero-3-phosphocholine
phenylmethylsulfonyl fluoride
-
30% inhibition at 50 mM
phosphatidic acid
-
-
procyanidin B-2,3,3'-di-O-gallate
-
IC50: 0.031 mM
procyanidin B-5,3,3'-di-O-gallate
-
IC50: 0.024 mM
propan-2-yl 4-(3,4-dichloro-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoate
propan-2-yl 4-(3-chloro-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoate
propan-2-yl 4-[3-chloro-4-(2-hydroxyanilino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl]benzoate
propan-2-yl 4-[3-chloro-4-(morpholin-4-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl]benzoate
propanolol
-
-
propyl 4-(3,4-dichloro-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoate
pyrrolidinecarbodithioic acid
i.e. PDTC, reduces production of platelet-activating factor (PAF) in H2O2-treated HUVEC cells
quercetin
resveratrol
-
0.157 microM, results in 50% inhibition in interleukin 1beta effect on catalytic activity
serine/threonine phosphatase
-
diminishes rates of acetylation for 1-alkyl-sn-glycero-3-phosphocholine and 1-acyl-sn-glycero-3-phosphocholine
-
sodium dodecylsulfate
-
inactivation at 0.1%
tenofovir-DF
-
remaining activity in human mesangial cells: 32%. By contrast no effect on activity is observed in blood of naiive patients treated with the drug
tetradecanoic acid
-
-
theaflavin
-
IC50: 0.032 mM
theaflavin-3'-O-gallate
-
IC50: 0.039 mM
theaflavin-3,3'-di-O-gallate
-
IC50: 0.028 mM
theaflavin-3-O-gallate
-
IC50: 0.058 mM
theasinensin A
-
IC50: 0.029 mM
Trifluoperazine
-
-
Triton X-100
-
75 and 95% inhibition at 0.2 and 0.6 mM respectively due to detergent
tyrosol
-
0.048 microM, results in 50% inhibition in interleukin 1beta effect on catalytic activity
Urea
-
inactivation at 8 mM
additional information
-