2.3.1.43: phosphatidylcholine-sterol O-acyltransferase

This is an abbreviated version!
For detailed information about phosphatidylcholine-sterol O-acyltransferase, go to the full flat file.

Word Map on EC 2.3.1.43

2.3.1.43

lipoprotein

hdl

apolipoproteins

cholesteryl

high-density

triglyceride

esterification

apoa-i

atherosclerosis

lipase

esterify

low-density

coronary

cardiovascular

hdl-cholesterol

unesterified

opacity

apoproteins

hypercholesterolemia

corneal

discoidal

atherogenic

subfractions

hdl-associated

triglyceride-rich

apoc-iii

postheparin

synthesis

hyperlipoproteinemia

lysolecithin

vldl-c

tg-rich

dimyristoyl

antiatherogenic

b-containing

normolipidemic

cholesterol-loaded

xanthoma

medicine

lipoprotein-cholesterol

chylomicron

acyl-coa:cholesterol

lipid-free

paraoxonase

apob-containing

hdl-mediated

3hcholesterol

drug development

lipid-poor

hypertriglyceridemia

tangier

very-low-density

non-hdl

Reaction

Synonyms

acyltransferase, lecithin-cholesterol, cholesterol transacyltransferase, LAT, LCAT, lecithin cholesterol acyl transferase, lecithin cholesterol acyltransferase, lecithin-cholesterol acyl transferase, lecithin-cholesterol acyltransferase, lecithin/cholesterol acyltransferase, lecithin: cholesterol acyltransferase, lecithin:cholesterol acyl-transferase, lecithin:cholesterol acyltransferase, lysolecithin acyltransferase, phospholipid-cholesterol acyltransferase, plasma lecithin-cholesterol acyltransferase, TgLCAT, TGME49_272420

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.43 phosphatidylcholine-sterol O-acyltransferase

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Results	in table
78	Activating Compound
197	AA Sequence
15	Application
1	CAS Registry Number
27	Cloned(Commentary)
3	Cofactor
2	Crystallization (Commentary)
2375	Disease/ Diagnostics
4	Expression
41	General Information
13	General Stability
1	IC50 Value
68	Inhibitors
1	Ki Value [mM]
25	KM Value [mM]
36	Localization
8	Metals/Ions
45	Molecular Weight [Da]
55	Natural Substrates/ Products (Substrates)
273	Organism
1	Pathway
15	PDB ID
23	pH Optimum
1	pH Stability
2	pI Value
26	Posttranslational Modification
28	Protein Variants
42	Purification (Commentary)
3	Reaction
2	Reaction Type
134	Reference
118	Source Tissue
55	Specific Activity [micromol/min/mg]
8	Storage Stability
218	Substrates and Products (Substrate)
33	Subunits
147	Synonyms
1	Systematic Name
26	Temperature Optimum [°C]
1	Temperature Stability [°C]

Crystallization

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Crystallization on EC 2.3.1.43 - phosphatidylcholine-sterol O-acyltransferase

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in complex with antibody 27C3, hanging drop vapor diffusion method, using 0.1 M HEPES (pH 7.0) and 5% (w/v) PEG 20000

Homo sapiens

P04180

757166

molecular dynamics simulation. LCAT anchors itself to lipoprotein surfaces by utilizing nonpolar amino acids located in the membrane-binding domain and the active site tunnel opening. The membrane-anchoring hydrophobic amino acids attract cholesterol molecules next to them. The apolipoprotein A-I-derived peptides from the LCAT-activating region bind to LCAT and promote its lipid surface interactions, although some of these peptides do not bind lipids individually. The transfer free-energy of phospholipid from the lipid bilayer into the active site is consistent with the activation energy of LCAT

Homo sapiens

P04180

757378